Live data from Hacker News

Untitled topic

news.ycombinator.com

81–90 of 382 posts

Re: undefined

#81
post #44

Earlier quoted context omitted.

It's been tested for years (decades? it's generic) as an anti-malaria drug. Any drug can be overdosed.

That's an oversimplification. The amount for an overdose is only around 3X a regular dose (2g vs 600mg) In contrast, most drugs for which you overdose need to be at much higher dosage multiples compared to the prescribed dose.

Acetaminophen is also easy to overdose and has been recommended as a fever reducer for Coronavirus.

Re: undefined

#82
post #2

The repeated recommendation to use a drug which has not been properly tested by the president of the most powerful nation on this planet seems inappropriate to me.

We all made fun of South Africa's Thabo Mbeki when he recommended beetroot, garlic and other herbs to combat HIV. Turns out, we have no reason. It did happen here, on primetime TV.

The FDA approved emergency expanded access for inhaled nitric oxide a couple days ago, which has the same mechanism of action as garlic and beet root. There is actually a plausible mechanism of action there, and a bunch of in vitro research.

Re: undefined

#83
post #70
post #2

The repeated recommendation to use a drug which has not been properly tested by the president of the most powerful nation on this planet seems inappropriate to me.

This is ridiculous. There has been studies and papers being written and released for MONTHS from all over the world. We’ve known about chloroquine since January. This INSISTENCE people keep having on politicizing this is infuriating and it’s going to get people killed. Stop doing this. Now is not the time for political point gathering.

I know you've got a point, but I genuinely can't tell which side you're having a go at.

Re: undefined

#84
post #70
post #2

The repeated recommendation to use a drug which has not been properly tested by the president of the most powerful nation on this planet seems inappropriate to me.

This is ridiculous. There has been studies and papers being written and released for MONTHS from all over the world. We’ve known about chloroquine since January. This INSISTENCE people keep having on politicizing this is infuriating and it’s going to get people killed. Stop doing this. Now is not the time for political point gathering.

Would have the man consumed the chloroquine if not for Trump broadcasting it? I'm willing to entertain both yes or no to this question, but I'm going to guess the gentlemen didn't know based off the scientific literature, but rather, the daily press briefings. And that differentiation does matter.

Re: undefined

#85
post #18

Earlier quoted context omitted.

https://www.bbc.com/news/51980731

He said doctors can administer it under new FDA guidance. He didn't say "drink an additive commonly used at aquariums to clean fish tanks." http://bannerhealth.mediaroom.com/chloroquinephosphate I don't see why every story needs to be about him.

But the nice part is, it’s been around for a long time, so we know that if it — if things don’t go as planned, it’s not going to kill anybody.

Surely you've noticed that some folk take the President's public statements at face value.

Re: undefined

#86

Earlier quoted context omitted.

Do you have an exact quote from the president where he recommends that the public obtain and self medicate with chloroquine? Or have you significantly altered his statements for your own political agenda?

> Now, a drug called chloroquine — and some people would add to it “hydroxy-.” Hydroxychloroquine. So chloroquine or hydroxychloroquine. Now, this is a common malaria drug. It is also a drug used for strong arthritis. If somebody has pretty serious arthritis, also uses this in a somewhat different form. But it is known as a malaria drug, and it’s been around for a long time and it’s very powerful. But the nice part i…

I'm reading "This drug is gonna be great." I'm not reading "take this drug without your doctor's orders".

Re: undefined

#87
This is what happens when you give bad advice to frightened people.

You know who you are. If you had an excuse before, you sure as hell don't have one any more.

If your intentions are good, you'll stop now, rather than risk the next death being your fault because it was the bad information you put out there that caused it.

If you don't stop, now that the stakes are as clear as they can be, then I hope for your sake that your conscience lets you rest easy, and that that's the only judgment you're ever called to answer. I would hope other people would choose to be kind, once all this is over. But I wouldn't want to bet my freedom or my life on it.

I would hope you'd choose to be kind, too. I would hope the fear of contributing to the death of an innocent, however foolish they may happen to be, would outweigh your investment in the sense of righteous certitude that moves you to do what you're doing. Or, if not that, then whatever else it is that motivates you.

Please don't let me down.

Re: undefined

#88

Earlier quoted context omitted.

A quick skim of the article does not show any quote stating you should self medicate. There are quotes misrepresenting which stage of approval it is in.

Verbatim quote from the President: "if things don’t go as planned, it’s not going to kill anybody." Edit: Yes, I realize what he probably meant . I know how meds work. I still think he should have chosen his wording more carefully.

I.e. even if the drug is ineffective, at least we know it doesn't have fatal side effects, because it has already been used widely and approved for malaria treatment after going through safety trials a long while ago. This is in contrast to experimental drugs, which don't just have questionable efficacy, but also unknown safety.

It goes without saying that like all prescription drugs which have been proven safe, chloroquine should only be taken when prescribed by a doctor, at the recommended dosage. Obviously if you self-medicate with any safe prescription drug, you risk harming yourself by overdosing.

Re: undefined

#89
post #81

Earlier quoted context omitted.

That's an oversimplification. The amount for an overdose is only around 3X a regular dose (2g vs 600mg) In contrast, most drugs for which you overdose need to be at much higher dosage multiples compared to the prescribed dose.

Acetaminophen is also easy to overdose and has been recommended as a fever reducer for Coronavirus.

Who is recommending acetaminophen for coronavirus fever reduction? Provide a source.

Re: undefined

#90
post #44

Earlier quoted context omitted.

It's been tested for years (decades? it's generic) as an anti-malaria drug. Any drug can be overdosed.

That's an oversimplification. The amount for an overdose is only around 3X a regular dose (2g vs 600mg) In contrast, most drugs for which you overdose need to be at much higher dosage multiples compared to the prescribed dose.

However nobody should be self-prescribing. The toxic dose is irrelevant because you shouldn’t be taking this drug without a doctor’s supervision. Lithium, a treatment for bipolar disorder is also very toxic and required blood level monitoring but it isn’t being criticized for having the therapeutic dose being so close to the toxic dose. But Trump hasn’t talked about Lithium, so thus nobody cares to complain about it.
Post reply on HN