81–90 of 320 posts
« The exact mechanism of antiviral intervention by chloroquine is not yet elucidated but is possibly a multitarget mechanism, depending on the time point at which the drug is added »
Is there not an argument that given chloroquine's apparent efficacy, albeit statistically weakly or improperly demonstrated (so far), along with its long history of relative safety in anti-malarial prophylaxis (with known caveats), set against an exponential growth in dangerous pneumonia - it is therefore rational to want to at least offer it to all suspected cases and healthworkers in balance of the serious risks th…
The possible side effects include permanent blindness. Giving this drug to people while you simply don't know if it does any good is only justifiable if you do it within a properly designed clinical trial. Which is the thing you should do. If you feel lots of people should get this drug - do a large trial. Will give us better data.
Earlier quoted context omitted.
I think everyone would like to see the CDC be better funded. Hindsight makes that an obvious mistake, but monitoring C19 should have been their number one priority in any case. From January onwards it was clear that it was the number one threat. There's still no explanation (afaik) for why they rolled their own test instead of using the WHO's test, nor have they effectively communicated their plans for ramping up tes…
There seems to be a really obvious explanation of why they rolled their own test instead of using the WHO's test: there was no WHO test when they did it, the two different tests were developed in parallel (and they're not the only country which developed their own test either, there are something like seven different ones used in various countries). The CDC had already been using its own test internally when the WHO…
I was intrigued by the results from the recent quick french study: https://www.mediterranee-infection.com/wp-content/uploads/20... I read through the paper, and it's not immediately obvious, but if you look at the two graphs at the bottom, the hydroxychloroquine is 75% effective in the first chart, but only 50% in the second one. That's because the actual test was: Control: 16 hydroxychloroquine: 14 hydroxychloroquin…
The study wasn't randomized. It tells you basically nothing. I really don't understand why anyone approves such studies. They could've done something useful and we'd know a little bit now.
Next time I am in a burning plane, I'll make sure to refuse a parachute, as the lack of studies means anecdotal evidence tells us basically nothing.
We definitely want more studies, but IMO we're reaching a tipping point. We have anecdotal evidence from China and South Korea, and this quite flawed, but at least data-containing study from France. Chloroquine's safety profile isn't great, but the safety profile of COVID is way worse. If you look at Chemotherapy for example, one would never take any of those drugs unless you had cancer. COVID isn't quite as bad as c…
The half life is 2 months. Any bad reaction will linger. Compared to antibiotics with a 8 hour half life. Lets stay home instead.
For a couple of weeks, fine. However on the other end of this spectrum is "Millions starve".
At some point we need to ask is that fair to the youth? (note: I'm an old fart)
Earlier quoted context omitted.
This is where having a fully funded CDC and pandemic team in the US pays off. They would have been paying very close attention for weeks on end in China, Italy and South Korea and many approaches could have been already dead-ended before it even significantly reached out shores. To say nothing of actually being in the process of ramping up medications that HAVE shown to be effective. It feels like we are starting fro…
>> fully funded CDC Is there evidence that more money would have solved the constant CDC problems and incompetencies that are coming up? It seems like a throwaway obvious statement, but plenty of government agencies - and private companies - don't operate a lot more effectively with more money.
We definitely want more studies, but IMO we're reaching a tipping point. We have anecdotal evidence from China and South Korea, and this quite flawed, but at least data-containing study from France. Chloroquine's safety profile isn't great, but the safety profile of COVID is way worse. If you look at Chemotherapy for example, one would never take any of those drugs unless you had cancer. COVID isn't quite as bad as c…
The half life is 2 months. Any bad reaction will linger. Compared to antibiotics with a 8 hour half life. Lets stay home instead.
I'm all for staying home for now, but at some point we will have to come out, and we need something to help those that are already infected.
If CQ works as prophylaxis, we could potentially have a sort of interim herd immunity by having large portions of the population that could tolerate CQ taking it prophylactically while we wait for a vaccine. This is basically the current approach in regions with a lot of Malaria, and they've been waiting for a vaccine for a very long time.
The danger of course is SARS-CoV-2 developing resistance to Chloroquine as Malaria has. We need lots of people working as fast as possible on a vaccine.
Going on a hunch or unproven stuff is simply going to give the anti-vaxxer idiots further ammo
The Quinism Foundation Warns of Dangers from Use of Antimalarial Quinolines Against COVID‑19. "Use of Chloroquine, Hydroxychloroquine, Mefloquine, Quinine, and Related Quinoline Drugs Risks Sudden and Lasting Neuropsychiatric Effects from Idiosyncratic Neurotoxicity." https://quinism.org/press-releases/dangers-of-antimalarial-q... The Anit-Malaria drugs They are pushing have a common ancestor to Fluoroquinolone antib…
The mental/physical damage they can produce is not something you would expect.
Is there not an argument that given chloroquine's apparent efficacy, albeit statistically weakly or improperly demonstrated (so far), along with its long history of relative safety in anti-malarial prophylaxis (with known caveats), set against an exponential growth in dangerous pneumonia - it is therefore rational to want to at least offer it to all suspected cases and healthworkers in balance of the serious risks th…