Chloroquine, past and present
blogs.sciencemag.org
Chloroquine, past and present
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Re: Chloroquine, past and present
#2And so to today. As I said yesterday, I find the reports of chloroquine/hydroxychloroquine activity against the coronovirus very interesting, but preliminary. There has as yet been no well-controlled trial, and unfortunately the effects seen are still the sort of thing that can look exciting but disappear when you look closely. I mean that. It happens all the time – ask anyone else who does drug research for a living. If this drug isn’t useful, then sending hundreds of millions of people out to swallow all of it that they can find will be a massive waste of time and money, and will actively harm people besides. This is not a benign compound; it should only be taken when you have a solid expectation of benefit, and (saying it again), we don’t yet have that. Better trials are cranking up right now: please, wait for those. The generic drug companies (Teva and Mylan, I’ve seen so far, and there’s this) that are cranking up production are doing the prudent thing – if this reads out well, we’ll need a lot of it. But we’ll need to give it to people who are in bad shape from the viral infection, too, remember that, and I fear that a lot of people around the world are just starting to take it now in hopes of a prophylactic effect, which is (saying it again) a bad idea.
Re: Chloroquine, past and present
#3This chloroquinine rush is already out of control. My pharmacy is already out of it and is unable to procure from other pharmacies (which are also out already!)
My pharmacist placed orders for all her patients to prefill prescriptions (where possible) for the next few months.
I can understand a shortage when there's a clear evidence-based need, but the rumour-mill hasn't even ramped to full bore yet and it's already harming people with a pre-existing need for the medication.
It's even worse _if_ the medication works to prevent or shorten c19 infections, because the people currently taking chloroquinine are very likely high-risk (immunocompromised) patients.
Really wish people would chill out.
Note - This affects me, as I take the medication. It's scary to think I could be without it at some point in the future as it's been practically life-changing.
Re: Chloroquine, past and present
#4This chloroquinine rush is already out of control. My pharmacy is already out of it and is unable to procure from other pharmacies (which are also out already!) My pharmacist placed orders for all her patients to prefill prescriptions (where possible) for the next few months. I can understand a shortage when there's a clear evidence-based need, but the rumour-mill hasn't even ramped to full bore yet and it's already…
We stocked up on my daughters medications last week, there was already a non-covid-19 related shortage. Thank god we got what we need for several weeks. Its pretty scary when you rely on a common drug and it runs out.
Re: Chloroquine, past and present
#5I was under the impression that chloroquine was used to facilitate cellular absorption of zinc and that the zinc was responsible for any antiviral behavior:
https://www.youtube.com/watch?v=dT6mHi_8V5E
Re: Chloroquine, past and present
#6The Quinism Foundation Warns of Dangers from Use of Antimalarial Quinolines Against COVID‑19.
"Use of Chloroquine, Hydroxychloroquine, Mefloquine, Quinine, and Related Quinoline Drugs Risks Sudden and Lasting Neuropsychiatric Effects from Idiosyncratic Neurotoxicity."
https://quinism.org/press-releases/dangers-of-antimalarial-q...
The Anit-Malaria drugs They are pushing have a common ancestor to Fluoroquinolone antibiotics have MANY FDA warnings. The FDA says they should not be used unless all other options have been exhausted.
Those that have already been devastated by Fluoroquinolones are extremely upset to hear that a related quinolines drug is being proposed. While these two drugs are technically in a different class, they share some common ancestors. They both share many of the devastating side effects.
I have put all the FDA warnings for Fluoroquinolone antibiotics on my late wife's website. Levaquin was a significant contributor to Karen's suicide. :-(
Re: Chloroquine, past and present
#7This chloroquinine rush is already out of control. My pharmacy is already out of it and is unable to procure from other pharmacies (which are also out already!) My pharmacist placed orders for all her patients to prefill prescriptions (where possible) for the next few months. I can understand a shortage when there's a clear evidence-based need, but the rumour-mill hasn't even ramped to full bore yet and it's already…
This is where having a fully funded CDC and pandemic team in the US pays off. They would have been paying very close attention for weeks on end in China, Italy and South Korea and many approaches could have been already dead-ended before it even significantly reached out shores.
To say nothing of actually being in the process of ramping up medications that HAVE shown to be effective. It feels like we are starting from ground zero when that should simply not be the case.
Re: Chloroquine, past and present
#8[deleted]
Re: Chloroquine, past and present
#9This chloroquinine rush is already out of control. My pharmacy is already out of it and is unable to procure from other pharmacies (which are also out already!) My pharmacist placed orders for all her patients to prefill prescriptions (where possible) for the next few months. I can understand a shortage when there's a clear evidence-based need, but the rumour-mill hasn't even ramped to full bore yet and it's already…
We stocked up on my daughters medications last week, there was already a non-covid-19 related shortage. Thank god we got what we need for several weeks. Its pretty scary when you rely on a common drug and it runs out.
Reminds me of a comment I read on Reddit some week ago; the commenter was going from store to store looking for disinfectant for a family member that has a prosthetic and needs to disinfect it daily, lest an infection gets into the wound.
Re: Chloroquine, past and present
#10The Quinism Foundation Warns of Dangers from Use of Antimalarial Quinolines Against COVID‑19. "Use of Chloroquine, Hydroxychloroquine, Mefloquine, Quinine, and Related Quinoline Drugs Risks Sudden and Lasting Neuropsychiatric Effects from Idiosyncratic Neurotoxicity." https://quinism.org/press-releases/dangers-of-antimalarial-q... The Anit-Malaria drugs They are pushing have a common ancestor to Fluoroquinolone antib…
"Two drugs, chloroquine and remdesivir, are being designated for Expanded Access, or “compassionate use,” by the FDA."
It's already available. Hopefully soon to the general public (it's prescription only btw).