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Bayer donates 3M chloroquine phosphate tablets for potential Covid-19 treatment

reuters.com

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Re: Bayer donates 3M chloroquine phosphate tablets for potential Covid-19 treatment

#51

Post by blhack »

cycrutchfield wrote: post #30
blhack wrote: post #24

To those who aren't aware of it, there was a recently completed (small) clinical study of hydroxychloroquine (and in some cases HCQ plus z-pack) just completed in France. The results are here: https://www.mediterranee-infection.com/wp-content/uploads/20... They're miraculous. This is a well-studied, mass-produced drug which has been around for 70 years and appears to be highly effective at treating this virus.

>They're miraculous. Where are you seeing that? Because what I see is a very non-rigorous, non-randomized study. Also, what about this part: >A total of 26 patients received hydroxychloroquine and 16 were control patients. Six hydroxychloroquine-treated patients were lost in follow-up during the survey because of early cessation of treatment. Reasons are as follows: three patients were transferred to intensive care u…

The findings they're claiming are nothing short of miraculous, and I think the people who were behind the trial, as well as everybody else even remotely interested in this (the entire world, I would say) should and likely does support a broader trial.

Re: Bayer donates 3M chloroquine phosphate tablets for potential Covid-19 treatment

#52

Post by blhack »

prostheticvamp wrote: post #33
cycrutchfield wrote: post #30

Earlier quoted context omitted.

>They're miraculous. Where are you seeing that? Because what I see is a very non-rigorous, non-randomized study. Also, what about this part: >A total of 26 patients received hydroxychloroquine and 16 were control patients. Six hydroxychloroquine-treated patients were lost in follow-up during the survey because of early cessation of treatment. Reasons are as follows: three patients were transferred to intensive care u…

Medical doctor and statistician weighing in just to say: I agree fully with what you wrote. No miracles observed.

I don't mean and disrespect to you as a physician, but there appear to be many experts who disagree with you to the point of acting out their disagreement at scale. Chloroquine has become a standard part of treatment for this disease in several countries, and its continued use seems to imply its efficacy.

Re: Bayer donates 3M chloroquine phosphate tablets for potential Covid-19 treatment

#53

Post by cameldrv »

ukabwlsbeux wrote: post #46
cycrutchfield wrote: post #30

Earlier quoted context omitted.

>They're miraculous. Where are you seeing that? Because what I see is a very non-rigorous, non-randomized study. Also, what about this part: >A total of 26 patients received hydroxychloroquine and 16 were control patients. Six hydroxychloroquine-treated patients were lost in follow-up during the survey because of early cessation of treatment. Reasons are as follows: three patients were transferred to intensive care u…

Mean age of control group is 15 years older than experimental too.

It's the other way around. The experimental group is older. That would suggest that HCQ would do even better if the ages were matched.

Re: Bayer donates 3M chloroquine phosphate tablets for potential Covid-19 treatment

#54

Post by blhack »

jacquesm wrote: post #50
batmansmk wrote: post #37

Earlier quoted context omitted.

Exactly! Reading the study, I don't see any hard evidence. Sounds like the next Forsythia.

> Sounds like the next Forsythia. For those that don't get the reference: https://en.wikipedia.org/wiki/Contagion_(2011_film) And that's exactly what it is.

Oh come on that isn't fair. Just do a simple google search for countries which have made chloroquine part of their standard treatment. The reference you're making here is to a person trying to exploit people during a pandemic with what was an obvious lie.

This is not that.

Re: Bayer donates 3M chloroquine phosphate tablets for potential Covid-19 treatment

#55

Post by peterburkimsher »

robocat wrote: post #15
Xunxi wrote: post #6

What will the effect of drinking quinine tonic be as a preventative measure?

Wikipedia: In the United States, the US Food and Drug Administration (FDA) limits the quinine content in tonic water to 83 ppm[3] (83 mg per liter if calculated by mass), while the daily therapeutic dose of quinine is in the range of 500–1000 mg,[4] and 10 mg/kg every eight hours for effective malaria prevention (2100 mg daily for a 70 kg adult). How much less than 83mg/litre is unclear. You would do yourself damage…

This is anecdata, so beware. For a full story, email me.

I have minor symptoms, and have been self-isolating since Wednesday (18) because many people around me were coughing on Monday (16) & Tuesday (17). The government here in NZ has not issued any lockdown instructions.

Due to comments here on HN, I decided to buy 4x 1.5 litres of ordinary Schweppes tonic water. Panic buying had not yet struck (it has now, but mostly bread, pasta, and toilet roll). I shared one bottle around the office, and gave one to my homestay family.

I've been drinking about 3 glasses per day, a litre at most. It's a sub-clinical dose for sub-clinical symptoms. The bitterness causes immediate sputum production in my mouth. Despite feeling a sore throat yesterday, I haven't yet started coughing.

I'm advocating for it in direct messages to friends: not because it's some miracle cure for the virus, but because it eases the coughing symptoms and thus might slow the spread. The placebo effect is probably also very real: I feel like I'm doing something, and that calms me down.

Re: Bayer donates 3M chloroquine phosphate tablets for potential Covid-19 treatment

#56

Post by endtime »

blhack wrote: post #52
prostheticvamp wrote: post #33

Earlier quoted context omitted.

Medical doctor and statistician weighing in just to say: I agree fully with what you wrote. No miracles observed.

I don't mean and disrespect to you as a physician, but there appear to be many experts who disagree with you to the point of acting out their disagreement at scale. Chloroquine has become a standard part of treatment for this disease in several countries, and its continued use seems to imply its efficacy.

I don't think he said no one is using (or should use) it, just that the results aren't "miraculous".

Re: Bayer donates 3M chloroquine phosphate tablets for potential Covid-19 treatment

#57

Post by SpikeDad »

blhack wrote: post #52
prostheticvamp wrote: post #33

Earlier quoted context omitted.

Medical doctor and statistician weighing in just to say: I agree fully with what you wrote. No miracles observed.

I don't mean and disrespect to you as a physician, but there appear to be many experts who disagree with you to the point of acting out their disagreement at scale. Chloroquine has become a standard part of treatment for this disease in several countries, and its continued use seems to imply its efficacy.

Haha. Continued use seems to imply it's efficacy. This might be the most illogical post on Hacker News in some time.

I think we could have a whole website of things that were continued to be used without a shred of evidence of effectiveness.

Re: Bayer donates 3M chloroquine phosphate tablets for potential Covid-19 treatment

#58

Post by krona »

blhack wrote: post #52
prostheticvamp wrote: post #33

Earlier quoted context omitted.

Medical doctor and statistician weighing in just to say: I agree fully with what you wrote. No miracles observed.

I don't mean and disrespect to you as a physician, but there appear to be many experts who disagree with you to the point of acting out their disagreement at scale. Chloroquine has become a standard part of treatment for this disease in several countries, and its continued use seems to imply its efficacy.

Miracle (noun): an extraordinary and welcome event that is not explicable by natural or scientific laws and is therefore attributed to a divine agency.

Re: Bayer donates 3M chloroquine phosphate tablets for potential Covid-19 treatment

#59

Post by mirimir »

Alex3917 wrote: post #9
bulldog13 wrote: post #3

Earlier quoted context omitted.

Are you a doctor or medical professional ?

If you want to see a doctor saying the same thing, just do a search on YouTube. I'm not really sure it changes the credibility of the information.

Doctors also claimed that smoking tobacco was safe. Just sayin'.

Re: Bayer donates 3M chloroquine phosphate tablets for potential Covid-19 treatment

#60

Post by Lldjjxnn »

wazoox wrote: post #48

Warning: chloroquine has strong side-effects, and very high toxicity, unfortunately pretty close to therapeutic doses, that may cause serious arrhythmia, and even heart attacks. Don't ever try to self-medicate with chloroquine.

Does hydroxycholoquinine have the same side effect profile as choloquinine
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