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Bayer donates 3M chloroquine phosphate tablets for potential Covid-19 treatment

reuters.com

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Re: Bayer donates 3M chloroquine phosphate tablets for potential Covid-19 treatment

#41

Post by snowwrestler »

blhack wrote: post #24

To those who aren't aware of it, there was a recently completed (small) clinical study of hydroxychloroquine (and in some cases HCQ plus z-pack) just completed in France. The results are here: https://www.mediterranee-infection.com/wp-content/uploads/20... They're miraculous. This is a well-studied, mass-produced drug which has been around for 70 years and appears to be highly effective at treating this virus.

To those who aren't aware of it, the reason someone thought to try this is that this type of drug has shown intermittent promise in treating viral infections for years. But to date it has never really panned out in clinical trials. (If it had, we would all be taking chloroquine every time we caught a serious virus like the flu).

Doesn't mean it can't be beneficial this time for this particular virus; we should always keep trying. I'm just saying it's probably a bit early to be calling miracles based on one small study.

Re: Bayer donates 3M chloroquine phosphate tablets for potential Covid-19 treatment

#42

Post by HarryHirsch »

hprotagonist wrote: post #27

https://news.ycombinator.com/item?id=22628302 Derek lowe reviews the evidence here and has far more of a positive take on it than i'd expected. (as in , "not obvious nonsense!")

No, he doesn't. Derek has a favourable opinion of favipiravir and in the footnote he calls the French trial "messy". That's very polite, considering the shape of the data.

Re: Bayer donates 3M chloroquine phosphate tablets for potential Covid-19 treatment

#43

Post by Mvandenbergh »

blhack wrote: post #24

To those who aren't aware of it, there was a recently completed (small) clinical study of hydroxychloroquine (and in some cases HCQ plus z-pack) just completed in France. The results are here: https://www.mediterranee-infection.com/wp-content/uploads/20... They're miraculous. This is a well-studied, mass-produced drug which has been around for 70 years and appears to be highly effective at treating this virus.

This is not a rigorous study and doesn't pretend to be but those are sufficiently impressive results that it is still a cause for hope.

You need meticulous study design when you're looking for small effect sizes, with a large enough effect you can extract useful information even from flawed data.

Re: Bayer donates 3M chloroquine phosphate tablets for potential Covid-19 treatment

#44

Post by amelius »

Alex3917 wrote: post #9
bulldog13 wrote: post #3

Earlier quoted context omitted.

Are you a doctor or medical professional ?

If you want to see a doctor saying the same thing, just do a search on YouTube. I'm not really sure it changes the credibility of the information.

But then you get "search bias" which would lower the credibility.

Re: Bayer donates 3M chloroquine phosphate tablets for potential Covid-19 treatment

#45

Post by semi-extrinsic »

viggity wrote: post #20

Does anyone know how quickly the production of Chloroquine Phosphate and Hydroxychloroquine can be ramped up (say, to the tune of 500M people * 7g per "course" = 3.5 million kilograms? I tried finding out how much chloroquine is prescribed world wide per year, but couldn't find it. It may give us a clue into how much is already being used. I know that it isn't used except for pregnant women as a malaria treatement be…

Not a medicinal chemist, but here is an overview of the synthesis routes we know of:

https://www.sciencedirect.com/topics/chemistry/chloroquine

From this, it doesn't look like there are any major hurdles in the necessary precursors. E.g. chloroaniline is very commonly used for making many drugs (incl. chlorhexidine), methyl acrylate is similarly in the six-figure-tonnes-per-year category, and that diamine also looks to have a nice synthesis route.

Fingers and toes crossed for this one.

Re: Bayer donates 3M chloroquine phosphate tablets for potential Covid-19 treatment

#46

Post by ukabwlsbeux »

cycrutchfield wrote: post #30
blhack wrote: post #24

To those who aren't aware of it, there was a recently completed (small) clinical study of hydroxychloroquine (and in some cases HCQ plus z-pack) just completed in France. The results are here: https://www.mediterranee-infection.com/wp-content/uploads/20... They're miraculous. This is a well-studied, mass-produced drug which has been around for 70 years and appears to be highly effective at treating this virus.

>They're miraculous. Where are you seeing that? Because what I see is a very non-rigorous, non-randomized study. Also, what about this part: >A total of 26 patients received hydroxychloroquine and 16 were control patients. Six hydroxychloroquine-treated patients were lost in follow-up during the survey because of early cessation of treatment. Reasons are as follows: three patients were transferred to intensive care u…

Mean age of control group is 15 years older than experimental too.

Re: Bayer donates 3M chloroquine phosphate tablets for potential Covid-19 treatment

#47

Post by HarryHirsch »

LinuxBender wrote: post #2

An alternate zinc ionophore with less side effects is Quercetin [1] [2] which some people here already take for other reasons, myself included. It is most beneficial if being taken prior to infection to slow the RNA transcoding process by getting more zinc into the cells, assuming one is not deficient in zinc to begin with. I mention this because by the time someone is talking to a doctor, the virus has likely alread…

Bioavailability of quercetin is low. That doesn't prevent the supplement industry from profiting from it, unfortunately. The upside is, since it's poorly absorbed from the gut, you probably won't die from it.

Re: Bayer donates 3M chloroquine phosphate tablets for potential Covid-19 treatment

#49

Post by swsieber »

cycrutchfield wrote: post #30
blhack wrote: post #24

To those who aren't aware of it, there was a recently completed (small) clinical study of hydroxychloroquine (and in some cases HCQ plus z-pack) just completed in France. The results are here: https://www.mediterranee-infection.com/wp-content/uploads/20... They're miraculous. This is a well-studied, mass-produced drug which has been around for 70 years and appears to be highly effective at treating this virus.

>They're miraculous. Where are you seeing that? Because what I see is a very non-rigorous, non-randomized study. Also, what about this part: >A total of 26 patients received hydroxychloroquine and 16 were control patients. Six hydroxychloroquine-treated patients were lost in follow-up during the survey because of early cessation of treatment. Reasons are as follows: three patients were transferred to intensive care u…

Luckily, it seems like a randomized study is underway.

Re: Bayer donates 3M chloroquine phosphate tablets for potential Covid-19 treatment

#50

Post by jacquesm »

batmansmk wrote: post #37
cycrutchfield wrote: post #30

Earlier quoted context omitted.

>They're miraculous. Where are you seeing that? Because what I see is a very non-rigorous, non-randomized study. Also, what about this part: >A total of 26 patients received hydroxychloroquine and 16 were control patients. Six hydroxychloroquine-treated patients were lost in follow-up during the survey because of early cessation of treatment. Reasons are as follows: three patients were transferred to intensive care u…

Exactly! Reading the study, I don't see any hard evidence. Sounds like the next Forsythia.

> Sounds like the next Forsythia.

For those that don't get the reference: https://en.wikipedia.org/wiki/Contagion_(2011_film)

And that's exactly what it is.

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