Here’s an article (without much information...) about an upcoming trial for Chloroquine in Australia.
https://www.news.com.au/lifestyle/health/health-problems/cor...
Chloroquine has shown apparent efficacy in treatment of Covid-19
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Re: Chloroquine has shown apparent efficacy in treatment of Covid-19
#32I have a fairly tame quinine allergy (and subsequently was incredibly relieved when artemisinin-based treatments became a thing) - this is interesting but also mildly horrifying news.
Re: Chloroquine has shown apparent efficacy in treatment of Covid-19
#33Re: Chloroquine has shown apparent efficacy in treatment of Covid-19
#34i currently take Plaquenil (Hydroxychloroquine) for rheumatoid arthritis, and my doctor did indicate it may be helpful against Covid but not enough tests to confirm. Is it close enough to chloroquine to be the same ?
Re: Chloroquine has shown apparent efficacy in treatment of Covid-19
#35Then we have a treatment (i.e., zinc gluconate + chloroquine): A zinc tablet (10-80 mg) dissolved slowly in the mouth, lavaging the throat and nose, while lying down will cease coronaviral replication on most of the surfaces of the upper respiratory system. Zinc sprays also work. This must be done within the first 3-4 days of infection with covid-19. The covid-19 virus' usual course is to first infect the eye, nose a…
So, I'm no medical professional, just an avid reader of such news. But I believe that most of this post is incorrect. I've seen no studies backing up the use of zinc for anything related to COVID-19. A search of pubmed for the terms 'covid zinc' or 'coronavirus zinc' show no papers referencing treatments. Same goes for medrxiv. There are a lot of cold "treatments" involving the use of zinc in the way you suggest. I h…
Not vouching for the suggested treatment but chloroquine acts as a zinc ionophere enabling increased zinc binding/intake in cells, inhibiting RNA-dependent RNA polymerase, which would theoretically ultimately encumber the replication of the virus.
Re: Chloroquine has shown apparent efficacy in treatment of Covid-19
#36I have a fairly tame quinine allergy (and subsequently was incredibly relieved when artemisinin-based treatments became a thing) - this is interesting but also mildly horrifying news.
There's also an anti-HIV medication that seems to be effective, though I don't know too much about it.
https://www.news.com.au/lifestyle/health/health-problems/cor...
Re: Chloroquine has shown apparent efficacy in treatment of Covid-19
#37Re: Chloroquine has shown apparent efficacy in treatment of Covid-19
#38It should go without saying that we can cheerlead for the emergence of effective treatments, but actual treatment decisions should be made by a doctor.
> actual treatment decisions should be made by a doctor.
Medical advice is given by doctors and other health professionals.
Treatment decisions are made by patients, those entrusted by patients to make decisions, or parents, guardians, or custodians who make decisions on behalf of patients.
Re: Chloroquine has shown apparent efficacy in treatment of Covid-19
#39Then we have a treatment (i.e., zinc gluconate + chloroquine): A zinc tablet (10-80 mg) dissolved slowly in the mouth, lavaging the throat and nose, while lying down will cease coronaviral replication on most of the surfaces of the upper respiratory system. Zinc sprays also work. This must be done within the first 3-4 days of infection with covid-19. The covid-19 virus' usual course is to first infect the eye, nose a…
> allowing time to clear the virus from the body without raising an excessive immune response ("cytokine storm") Citation requested, that cytokine storms are a common pathology associated with Covid-19. Because (a) I haven't seen that in the literature, & (b) it's at odds with the published age-banded mortality rates.
"We propose that the immunomodulatory effect of hydroxychloroquine also may be useful in controlling the cytokine storm that occurs late-phase in critically ill SARS-CoV-2 infected patients."
[0]https://academic.oup.com/cid/advance-article/doi/10.1093/cid...
Re: Chloroquine has shown apparent efficacy in treatment of Covid-19
#40The publication is from 02/18/20 (as stated in the footer). Why didn’t gain it more traction?
UK gov banned parallel export of Kaletra and chloroquine phosphate on 26th Feb. There's traction in the media, then there's traction with competent men in boring grey suits.
(Although given that we seem to have a fairly aggressive mortality curve, I'm not optimistic about this one).