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How to fight the coronavirus SARS-CoV-2 and its disease, Covid-19 [pdf]

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Re: How to fight the coronavirus SARS-CoV-2 and its disease, Covid-19 [pdf]

#2
Just to check the source, these are the same slides (same Drive doc) tweeted by the listed author on the slides [1], who is a neurobiology and bioengineering professor at Stanford.

If you want an understandable, relatively short but info-dense writeup from a sober expert (there hasn’t been much of this on HN) this is nice.

[1] https://mobile.twitter.com/michaelzlin?lang=en

Re: How to fight the coronavirus SARS-CoV-2 and its disease, Covid-19 [pdf]

#3
I've added this to my list of resources for my blog audience, which I define as people who are curious about the science and have enough technical background to understand better than simplified popular explanations. My resource list is open source and takes issues and pull requests.

[1] https://raphlinus.github.io/covid/2020/03/14/covid.html

Re: How to fight the coronavirus SARS-CoV-2 and its disease, Covid-19 [pdf]

#4
I'd like to see more information on what to do if you are sick. Even younger people have gotten serious respiratory complications and it would be great to have information on how to care for yourself or your family short of heading to the hospital and contributing to the overwhelming of their staff.

Re: How to fight the coronavirus SARS-CoV-2 and its disease, Covid-19 [pdf]

#5

I'd like to see more information on what to do if you are sick. Even younger people have gotten serious respiratory complications and it would be great to have information on how to care for yourself or your family short of heading to the hospital and contributing to the overwhelming of their staff.

The most authoritative source is (still) the WHO guidelines [1], though the audience for this is health care professionals, not patients. Your national and local public health departments may have more updated and tailored information.

A popular article is "What Will You Do If You Start Coughing?" by James Hamblin [2], though this is heavier on public policy concerns than specific targeted advice.

If anyone can find a really well-communicated set of advice on this, I'll gladly add it to my resource list. The need for such things is urgent, and I'm extremely frustrated about the poor quality and distribution of resources, which is why I'm putting time and energy into curating my own resource list.

[1] https://www.who.int/publications-detail/home-care-for-patien...

[2] https://www.theatlantic.com/health/archive/2020/03/where-do-...

Re: How to fight the coronavirus SARS-CoV-2 and its disease, Covid-19 [pdf]

#7

I'd like to see more information on what to do if you are sick. Even younger people have gotten serious respiratory complications and it would be great to have information on how to care for yourself or your family short of heading to the hospital and contributing to the overwhelming of their staff.

Be careful with NSAIDs as they may exacerbate symptoms. [1]

[1]: https://www.theguardian.com/world/2020/mar/14/anti-inflammat...

Re: How to fight the coronavirus SARS-CoV-2 and its disease, Covid-19 [pdf]

#8

How do we know the doubling time? That seems like the biggest assumption that we're not sure about. I've seen 1 week, 5 days, and even recently 3 days.

Look at the graphs on "our world in data": https://ourworldindata.org/coronavirus#trajectories-since-th...

Based on this, 3 days does indeed look like the doubling time. However, be careful when interpreting this data, as it conflates increases in testing coverage with actual viral spread. If you look at countries with excellent testing, such as South Korea, it was still in the 3 day range, though today they thankfully have transmission comparatively under control.

Re: How to fight the coronavirus SARS-CoV-2 and its disease, Covid-19 [pdf]

#9
post #7

I'd like to see more information on what to do if you are sick. Even younger people have gotten serious respiratory complications and it would be great to have information on how to care for yourself or your family short of heading to the hospital and contributing to the overwhelming of their staff.

Be careful with NSAIDs as they may exacerbate symptoms. [1] [1]: https://www.theguardian.com/world/2020/mar/14/anti-inflammat...

Is there an authoritative source for this other than the French public health authorities? I haven't seen references to it at all in epi Twitter.

Re: How to fight the coronavirus SARS-CoV-2 and its disease, Covid-19 [pdf]

#10

How do we know the doubling time? That seems like the biggest assumption that we're not sure about. I've seen 1 week, 5 days, and even recently 3 days.

Look at the graphs on "our world in data": https://ourworldindata.org/coronavirus#trajectories-since-th... Based on this, 3 days does indeed look like the doubling time. However, be careful when interpreting this data, as it conflates increases in testing coverage with actual viral spread. If you look at countries with excellent testing, such as South Korea, it was still in the 3 day range, though today they thankful…

Thanks for linking to that graph. That's a great resource!

At 3 days that changes both how much we have to slow it down, and how quickly we need to start slowing it down.

Not to mention that if it's 15 days from infection to diagnosis then that's 5 doubling times. So by the time we realize we didn't do enough it's way too late to avoid a complete catastrophe.

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