Chloroquine, a drug mostly used against malaria, was shown in the 2000s to have some effect on SARS-CoV; in cell-culture studies it both reduces the virus’s ability to get into cells and its ability to reproduce once inside them, possibly by altering the acidity of the Golgi apparatus http://archive.vn/yfAWD
Chloroquine phosphate has shown apparent efficacy in treating Covid-19
141–150 of 174 posts
Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19
#142I can't seem to find information on whether Chloroquine would be taken prophylactically to be effective, or only after diagnosis and symptoms appear.
Probably works as a prophylactic. Unproven. I'm actually taking it at the malarial prophylactic dose (500mg/wk). There is some info here from a doctor https://www.reddit.com/r/medicine/comments/fbfj0r/covid19_pr... There is some evidence that hydroxychloroquine may be better as a prophylactic. Here's medcram talking about it from in vitro results https://youtu.be/vE4_LsftNKM?t=192 Re real patients I thought this inte…
My wife was tested yesterday - she has fever sympthoms. The first thing I did was down 500mg of Chloroquine. I am in an at-risk group. Then i took the kids to our country house. Fingers crossed for her today. 36 hrs after she came home from work with a fever i am still fever free.
Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19
#143Earlier quoted context omitted.
Therapeutic index of chloroquine isn't very high, and at the doses it's recommended for corona it's rather close to lethal doses, something like within an order of magnitude. Malaria prophylaxis is dosed -once- a weeek. Half-life 60-70 hours. Covid treatment is -twice daily-.
Actually, no. The therapeutic index of chloroquine in the treatment of covid-19 is relatively high. Some people take chloroquine or hydroxychloroquine at about half the acute dosage used for covid-19 (autoimmune disorders) for literal years. Given the half life as you mentioned, once or twice a week with enough lead time would be a sufficient dosage against covid-19 too. It's just that if you want to reach the concen…
chloroquine is not frequently used for autoimmune.
At doses used for corona, it is within 50% of margin, or even lower if you are a slow metabolizer of an LD50 dose.
plaquenil on the other hand does have a higher therapeutic index.
The other major disadvantage is that these drugs can interact with protease inhibitors.
Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19
#144In Africa when you suffer from Malaria they gradually give you Chloroquine, Amodiaquine or even Quinine. From my experience, Quinine is the strongest. I grew up taking those medicines. Man. They knock you out. Your ears are no longer working the first 3 days of taking Quinine. You lose the sense of smell. I guess they slow down the Corona 19 virus. My mom has already sent me Amodiaquine and Quinine here in Italy.
I'm wondering why they add quininne to some kinds of Schweppes. And I like the taste btw
Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19
#145Earlier quoted context omitted.
> Then you'll know because I volunteered for it. Clinical trials are already fast-tracked during epidemics; if you're really interested you may even be selected for one. But going out and randomly buying medicine because it seems like it might work (even though it might not, but you're cured without it, which means you're going to go out and tell everyone else to go buy it too) might not necessarily be the best way t…
> But going out and randomly buying medicine because it seems like it might work (even though it might not, but you're cured without it, which means you're going to go out and tell everyone else to go buy it too) might not necessarily be the best way to deal with this. Hey, that's okay, let me live or die on my own terms. It's my body. Stop trying to rule it. I'm not making you take it. How about you don't make me no…
> It's my body.
...but your body will take up a hospital bed and a team of healthcare professionals to deal with the side effects, thus taking them away from other patients.
Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19
#146Earlier quoted context omitted.
Probably works as a prophylactic. Unproven. I'm actually taking it at the malarial prophylactic dose (500mg/wk). There is some info here from a doctor https://www.reddit.com/r/medicine/comments/fbfj0r/covid19_pr... There is some evidence that hydroxychloroquine may be better as a prophylactic. Here's medcram talking about it from in vitro results https://youtu.be/vE4_LsftNKM?t=192 Re real patients I thought this inte…
My wife was tested yesterday - she has fever sympthoms. The first thing I did was down 500mg of Chloroquine. I am in an at-risk group. Then i took the kids to our country house. Fingers crossed for her today. 36 hrs after she came home from work with a fever i am still fever free.
Don't mix it with hydroxychloroqine. They can cause a heart attack when combined.
Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19
#147Chloroquine phosphate, an old drug for treatment of malaria, is shown to have apparent efficacy and acceptable safety against COVID-19 associated pneumonia in multicenter clinical trials conducted in China. The drug is recommended to be included in the next version of the Guidelines for the Prevention, Diagnosis, and Treatment of Pneumonia Caused by COVID-19 issued by the National Health Commission of the People's Re…
Yes, that's the abstract
Or is it?
Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19
#148Earlier quoted context omitted.
Actually, no. The therapeutic index of chloroquine in the treatment of covid-19 is relatively high. Some people take chloroquine or hydroxychloroquine at about half the acute dosage used for covid-19 (autoimmune disorders) for literal years. Given the half life as you mentioned, once or twice a week with enough lead time would be a sufficient dosage against covid-19 too. It's just that if you want to reach the concen…
chloroquine is not frequently used for autoimmune. At doses used for corona, it is within 50% of margin, or even lower if you are a slow metabolizer of an LD50 dose. plaquenil on the other hand does have a higher therapeutic index. The other major disadvantage is that these drugs can interact with protease inhibitors.
> The other major disadvantage is that these drugs can interact with protease inhibitors
What are the possible consequences of this?
Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19
#149Earlier quoted context omitted.
Probably works as a prophylactic. Unproven. I'm actually taking it at the malarial prophylactic dose (500mg/wk). There is some info here from a doctor https://www.reddit.com/r/medicine/comments/fbfj0r/covid19_pr... There is some evidence that hydroxychloroquine may be better as a prophylactic. Here's medcram talking about it from in vitro results https://youtu.be/vE4_LsftNKM?t=192 Re real patients I thought this inte…
My wife was tested yesterday - she has fever sympthoms. The first thing I did was down 500mg of Chloroquine. I am in an at-risk group. Then i took the kids to our country house. Fingers crossed for her today. 36 hrs after she came home from work with a fever i am still fever free.
Good luck.
Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19
#150Earlier quoted context omitted.
My wife was tested yesterday - she has fever sympthoms. The first thing I did was down 500mg of Chloroquine. I am in an at-risk group. Then i took the kids to our country house. Fingers crossed for her today. 36 hrs after she came home from work with a fever i am still fever free.
Don't mix it with hydroxychloroqine. They can cause a heart attack when combined.
prolonged qt interval. Yeah.