P3: Pandemic Prevention Platform (2017) • Hacker News Board

Re: P3: Pandemic Prevention Platform (2017)

#51

Post by grey-area » Fri, Mar 13, 2020, 12:37 PM UTC

bluGill wrote: post #47

pengaru wrote: post #40

Earlier quoted context omitted.

There's a complete lack of leadership in handling this pandemic in large part because this incompetent administration disbanded the national security team global health security and biodefense directorate. https://www.washingtonpost.com/news/to-your-health/wp/2018/0...

I don't know, it appears to me that we are running a long in place plan. (Other than troubles with testing kits which can be blamed on a one time case, but there is surely mismanagement in there). We are not panicking, as things prove to be getting worse we are seeing more and more action. By long in place, I mean first made many years ago and updated regularly as things change. That is the CDC's job. It is tempting…

Was it part of the plan for the president to talk about hoaxes, a 'foreign' virus, and deny there is a problem?

Re: P3: Pandemic Prevention Platform (2017)

#52

Post by brrrrr1 » Fri, Mar 13, 2020, 12:57 PM UTC

bluGill wrote: post #49

brrrrr1 wrote: post #43

With all due respect - does anyone believe the US army can deal with a pandemic? I mean you cant just shoot a huge number of weapons and kill it. That army hasn’t even been able to win wars against tribes, how can it win against a virus? I get it, there is a lot of PR surrounding it, but a pandemic is a real issue that requires science not dumb muscle. Somehow I believe the US and its army are the opposite of a solut…

For many years it has been a worry of any competent military that the enemy is going to release a bio-weapon. As such every army is be preparing for something. They won't know what exactly is coming, but they have processes in place to deal with it as best they can. That means supplies in place, and people training in using them - it might mean a generic gas mask instead of a N95 filter, but it will get the job done.…

See, competent governments dont need the army for medical supplies. Also it appears the US army is not prepared at all. Lack of tests, late response, a commander in chief ignorant of the problem. The US army is indeed prepared for securing an area that i am sure of. Pointing weapons is not particularly difficult. Perhaps it is time to reflect over what is marketing and what is real about the army? I hope i am wrong but from where i stand the us army is sheer numbers of people and bullets and loads and loads of pr.

Re: P3: Pandemic Prevention Platform (2017)

#53

Post by bluGill » Fri, Mar 13, 2020, 12:58 PM UTC

grey-area wrote: post #51

bluGill wrote: post #47

Earlier quoted context omitted.

I don't know, it appears to me that we are running a long in place plan. (Other than troubles with testing kits which can be blamed on a one time case, but there is surely mismanagement in there). We are not panicking, as things prove to be getting worse we are seeing more and more action. By long in place, I mean first made many years ago and updated regularly as things change. That is the CDC's job. It is tempting…

Was it part of the plan for the president to talk about hoaxes, a 'foreign' virus, and deny there is a problem?

I'm talking about the execution of what is happening on the ground. The President has a long history of overstating things and otherwise words not matching actions.

Re: P3: Pandemic Prevention Platform (2017)

#54

Post by DrScientist » Fri, Mar 13, 2020, 1:39 PM UTC

_tfi1 wrote: post #50

DrScientist wrote: post #45

Essentially you go from recovering patient to 20,000 therapeutic doses in 60-90 days. Note it is not a vaccine - a vaccine is something like part of a virus that then drives an immune response ( body evolves antibodies against it ) - here you are taking an antibody sequence you know works and directly putting that in the body and genetically programming the body to make it. Here's how: - find and clone the patients o…

It works well in humans: https://investors.modernatx.com/news-releases/news-release-d... Main finding was at the high dose, there were some adverse events but no serious adverse events, and they all self-resolved without intervention. At the lower doses (0.3 and 0.1mpk), it still provided months of protection against infection assuming the "protective level" is accurate.

Yep - it can work.

However, normally there is a long and potentially winding road between a phase 1, through phases II & III to a successful market launch.

Re: P3: Pandemic Prevention Platform (2017)

#55

Post by microcolonel » Fri, Mar 13, 2020, 1:56 PM UTC

brrrrr1 wrote: post #52

bluGill wrote: post #49

Earlier quoted context omitted.

For many years it has been a worry of any competent military that the enemy is going to release a bio-weapon. As such every army is be preparing for something. They won't know what exactly is coming, but they have processes in place to deal with it as best they can. That means supplies in place, and people training in using them - it might mean a generic gas mask instead of a N95 filter, but it will get the job done.…

See, competent governments dont need the army for medical supplies. Also it appears the US army is not prepared at all. Lack of tests, late response, a commander in chief ignorant of the problem. The US army is indeed prepared for securing an area that i am sure of. Pointing weapons is not particularly difficult. Perhaps it is time to reflect over what is marketing and what is real about the army? I hope i am wrong b…

Well, if you know so much about preventing the spread of infectious disease, quit whining on HN and do something productive for a change.

DARPA has advanced needs, which is why they develop advanced technology. Most people do not think of needing the things that the military needs, because most people's lives are not as challenging as a soldier's.

Re: P3: Pandemic Prevention Platform (2017)

#56

Post by terrislinenbach » Fri, Mar 13, 2020, 4:00 PM UTC

That's working well

Re: P3: Pandemic Prevention Platform (2017)

#57

Post by brrrrr1 » Fri, Mar 13, 2020, 5:53 PM UTC

microcolonel wrote: post #55

brrrrr1 wrote: post #52

Earlier quoted context omitted.

See, competent governments dont need the army for medical supplies. Also it appears the US army is not prepared at all. Lack of tests, late response, a commander in chief ignorant of the problem. The US army is indeed prepared for securing an area that i am sure of. Pointing weapons is not particularly difficult. Perhaps it is time to reflect over what is marketing and what is real about the army? I hope i am wrong b…

Well, if you know so much about preventing the spread of infectious disease, quit whining on HN and do something productive for a change. DARPA has advanced needs, which is why they develop advanced technology. Most people do not think of needing the things that the military needs, because most people's lives are not as challenging as a soldier's.

I know and i agree - seems like the us government doesnt care about the hard life of us soldiers, since it ignores the struggle of so many veterans. I am ok, Europe we have universal healthcare, and we dont need the “military” to take steps in that regard, nor do we elect idiots like trump in power to tel us fake scientific facts. Therefore i can afford sitting and pointing out how the us is a joke in terms of healthcare and its army is a bully as it can not do more than point and shoot. idiot.

Re: P3: Pandemic Prevention Platform (2017)

#58

Post by m0zg » Fri, Mar 13, 2020, 6:32 PM UTC

geofft wrote: post #46

m0zg wrote: post #41

Earlier quoted context omitted.

Care to explain why there was lack of leadership in 2009 when 57 million Americans got infected with H1N1? Or why Ebola response was also botched? There seems to be a long history of incompetence here. You can't fix incompetence by giving the incompetent more money or keeping them around.

Neither of those responses were botched, sorry. And yes, you can in fact fix incompetence by giving the incompetent organization more money. Organizations are made up of people, and those people have varying levels of competence, and the set of people isn't fixed, either. Sometimes you have competent ICs begging for funding and incompetent managers who can't present the case for it. Sometimes you have competent manag…

Ah, but you see, the CDC took it upon itself to fight Ebola in Africa. And that part went as well as you'd expect after seeing their current performance: they're still dealing with it, years later.

Re: P3: Pandemic Prevention Platform (2017)

#59

Post by m0zg » Fri, Mar 13, 2020, 7:38 PM UTC

bluGill wrote: post #53

grey-area wrote: post #51

Earlier quoted context omitted.

Was it part of the plan for the president to talk about hoaxes, a 'foreign' virus, and deny there is a problem?

I'm talking about the execution of what is happening on the ground. The President has a long history of overstating things and otherwise words not matching actions.

>> The President has a long history of overstating things

Also known in negotiation as "anchoring" - you give people a crazy, exaggerated version of what you want, then you tone it down and easily get what you really wanted to begin with. Anyone who ever participated in any kind of a business negotiation would recognize this immediately. But 99.99% of people haven't negotiated anything ever in their lives, so they don't.

People treat Trump as this linear simpleton, and he plays along, but he's not.

Re: P3: Pandemic Prevention Platform (2017)

#60

Post by microcolonel » Fri, Mar 13, 2020, 9:02 PM UTC

brrrrr1 wrote: post #57

microcolonel wrote: post #55

Earlier quoted context omitted.

Well, if you know so much about preventing the spread of infectious disease, quit whining on HN and do something productive for a change. DARPA has advanced needs, which is why they develop advanced technology. Most people do not think of needing the things that the military needs, because most people's lives are not as challenging as a soldier's.

I know and i agree - seems like the us government doesnt care about the hard life of us soldiers, since it ignores the struggle of so many veterans. I am ok, Europe we have universal healthcare, and we dont need the “military” to take steps in that regard, nor do we elect idiots like trump in power to tel us fake scientific facts. Therefore i can afford sitting and pointing out how the us is a joke in terms of health…

We have universal healthcare here in Canada, and we have basically no ability to care for sufferers of this pandemic. The U.S. has a lot more acute care facilities, a lot more response.

These policies are not a panacea, you need strong, accountable institutions for any of these things to be a benefit. Italy's hospitals have been over capacity for more than a week now, we will be soon, and so will the U.S.

Also, the U.S. defense establishment and industry is the source of many of the medical advancements you pay taxes for today, you don't live alone in the world. It is extremely childish to lash out, and call everyone a joke or a bully or an idiot, when these advancements are basically stagnant in your society, but people are willing to share them with you.

We're all in this together, whether you like it or not.