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Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) (2018)

ncbi.nlm.nih.gov

11–20 of 23 posts

Re: Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) (2018)

#11

Anyone with actual knowledge know the state of ACE2 inhibitor and chloroquinine efficacy?

Well, the Chinese claim chloroquine is effective in domestic RCT. And since China seems to be light years ahead of CDC/FDA, I'm inclined to believe them.

What a dangerous line of thinking you have.

Re: Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) (2018)

#13

Anyone with actual knowledge know the state of ACE2 inhibitor and chloroquinine efficacy?

Here is a paper from clinicians:

"Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies."

What China did there was they spent huge effort to find possible cures from existing drugs in the entire drug database known to mankind, herbal medicines included.

Safety is kind of validated because it's known drug, the dosage might be different but I am sure some were tested with high dosages too.

https://www.ncbi.nlm.nih.gov/pubmed/32074550

Re: Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) (2018)

#14
post #6

Anyone with actual knowledge know the state of ACE2 inhibitor and chloroquinine efficacy?

No actual knowledge, but apparently the way Coronaviruses kill your lung cells is by inhibiting their ACE2 receptors, so I doubt taking an additional ACE2 inhibitor would be helpful. C.f.: https://www.stephenharrodbuhner.com/wp-content/uploads/2020/...

https://www.instagram.com/tv/B9nlVtHgGE0/?igshid=lxc09jpkk96...

Second part of this video is a helpful explanation of how it attacks.

Re: Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) (2018)

#15
post #9

I would have liked (2018) in the title since it's an article from March 2018. At first glance I interpreted that it was directly tested on the current strain.

I flagged it because I was happy and thought it's the result of the new trial that supposed to come out in a few weeks. I'm disappointed now :(

Re: Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) (2018)

#16
post #9

I would have liked (2018) in the title since it's an article from March 2018. At first glance I interpreted that it was directly tested on the current strain.

I flagged it because I was happy and thought it's the result of the new trial that supposed to come out in a few weeks. I'm disappointed now :(

OOC, what does flagging do exactly? What does a flag mean here?

Re: Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) (2018)

#18
post #9

I would have liked (2018) in the title since it's an article from March 2018. At first glance I interpreted that it was directly tested on the current strain.

You can email the mods using the footer Contact link to fix the year and they'll do so. (I emailed them this time.)

Re: Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) (2018)

#19

Earlier quoted context omitted.

Well, the Chinese claim chloroquine is effective in domestic RCT. And since China seems to be light years ahead of CDC/FDA, I'm inclined to believe them.

What a dangerous line of thinking you have.

I can't tell. Is this /s?

Why should I distrust an Chinese RCT over an RCT the US hasn't even bothered to consider?

Re: Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) (2018)

#20
post #16

Earlier quoted context omitted.

I flagged it because I was happy and thought it's the result of the new trial that supposed to come out in a few weeks. I'm disappointed now :(

OOC, what does flagging do exactly? What does a flag mean here?

I think it's a signal for the moderators to take some action about the article. If many people flag it, they take it down or modify it.
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