Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) (2018)
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Re: Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) (2018)
#2I've been wondering if an antiviral will help in this.
Re: Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) (2018)
#3Looks like the NIH started a clinical trial of it as a potential treatment for COVID-19 a couple weeks ago: https://www.nih.gov/news-events/news-releases/nih-clinical-t...
There's also ongoing clinical trials of the drug in China.
Re: Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) (2018)
#4Anyone with actual knowledge know the state of ACE2 inhibitor and chloroquinine efficacy?
Re: Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) (2018)
#5The title is shortened in a somewhat misleading way, making it sound at if this might be about a clinical study.
The full title is: "Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease."
What this is is a study performed in mice, trying to work out the mechanism of action of Remdesivir, which is known to inhibit SARS-CoV-2 in vitro.
What's going to be really interesting is what comes out of ongoing clinical studies: https://www.gilead.com/purpose/advancing-global-health/covid...
Re: Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) (2018)
#6Anyone with actual knowledge know the state of ACE2 inhibitor and chloroquinine efficacy?
No actual knowledge, but apparently the way Coronaviruses kill your lung cells is by inhibiting their ACE2 receptors, so I doubt taking an additional ACE2 inhibitor would be helpful. C.f.:
https://www.stephenharrodbuhner.com/wp-content/uploads/2020/...
Re: Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) (2018)
#7Anyone with actual knowledge know the state of ACE2 inhibitor and chloroquinine efficacy?
Well, the Chinese claim chloroquine is effective in domestic RCT.
And since China seems to be light years ahead of CDC/FDA, I'm inclined to believe them.
Re: Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) (2018)
#82018 ?
Re: Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) (2018)
#9I would have liked (2018) in the title since it's an article from March 2018.
At first glance I interpreted that it was directly tested on the current strain.
Re: Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) (2018)
#10A lot more info and molecular/target details about Remdesivir available here: https://www.drugbank.ca/drugs/DB14761 (full disclosure this is my site).