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Chloroquine is available without prescription in many West African counties, and is used liberally anytime a child has a fever. At this point, I would label it as dangerous as aspirin.
I understand there is probably no connection between the two sentences but to be clear as far as I know Aspirin is dangerous for children.
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Yeah, I remember reading something similar years ago. But I suspect with the proliferation of "craft tonic water" there may be some "flavours" that don't contain quinine at all. And 6L of tonic water is... quite a lot.
You can boil it down presumably. Probably won’t taste very good though. (I do not recommend this and am not a doctor)
Earlier quoted context omitted.
Yeah, I remember reading something similar years ago. But I suspect with the proliferation of "craft tonic water" there may be some "flavours" that don't contain quinine at all. And 6L of tonic water is... quite a lot.
I read somewhere that gin & tonic was invented because they needed the gin to cover up the taste of the quinine, since the tonic needed to have a _lot_ of quinine to be effective. Shudder.
Mentioned:
Kaletra, an anti-HIV medication that includes the drugs lopinavir and ritonavir.
Hydroxychloroquine, sold under the brand name Plaquenil.
[1] https://www.upi.com/Top_News/World-News/2020/03/12/South-Kor...
Earlier quoted context omitted.
I read somewhere that gin & tonic was invented because they needed the gin to cover up the taste of the quinine, since the tonic needed to have a _lot_ of quinine to be effective. Shudder.
As someone who has taken uncoated chloroquine tablets mumble years ago, the taste is one of the most foul bitter over-riding tastes one will ever encounter. No amount of sugar mixed in with it took the edge off the taste. The only thing that did it was when they coated the tablets, preventing the chloroquine from touching the tongue.
I can't seem to find information on whether Chloroquine would be taken prophylactically to be effective, or only after diagnosis and symptoms appear.
This will be a moot point for the foreseeable future, since if this actually works, limited supplies will be redirected to people who are actually infected.
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The alternative is drowning in your own body fluids after you're turned away by overwhelmed hospitals. Or watching it happen helplessly to your loved ones after they're turned away for being too old, as is happening in Italy. And in any case Chloroquine is a well studied, proven safe drug with minimal side effects and a high therapeutic ratio. Nanny states breed incompetence.
Therapeutic index of chloroquine isn't very high, and at the doses it's recommended for corona it's rather close to lethal doses, something like within an order of magnitude. Malaria prophylaxis is dosed -once- a weeek. Half-life 60-70 hours. Covid treatment is -twice daily-.
The therapeutic index of chloroquine in the treatment of covid-19 is relatively high. Some people take chloroquine or hydroxychloroquine at about half the acute dosage used for covid-19 (autoimmune disorders) for literal years.
Given the half life as you mentioned, once or twice a week with enough lead time would be a sufficient dosage against covid-19 too. It's just that if you want to reach the concentration of chloroquine that you would have to take it over a long time otherwise, you need very high doses. And since you're already infected and have a ton of the virus, you also need higher concentrations than for prophylaxis.
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Yes, I was reading about this recently. Another study compared zinc uptake into the cytosol for various extracellular zinc levels, with and without chloroquine. I noticed when looking at the data, that while chloroquine facilitated a massive uptake a zinc, it was still true that increasing the extracellular zinc concentration (without chloroquine) still increased the cytosol's zinc concentration (by a lesser amount).…
One of the side effects of zinc overdose is loss of sense of smell, sometimes permanently. Please research all aspects before use.
i don't think anyone except hypochondriacs are in danger of zinc overdose
> • The outcomes of some current clinical trials of chloroquine in China have been announced, without access to the data. Shameless tangent, China has just booted its most competent respiratory disease epidemiologist from heading epidemic control committee for not backing Xi Jinping's "herbal remedies" https://www.taiwannews.com.tw/en/news/3895540
:( gov is backing cow dung, urine and alike here.
> • The outcomes of some current clinical trials of chloroquine in China have been announced, without access to the data. Shameless tangent, China has just booted its most competent respiratory disease epidemiologist from heading epidemic control committee for not backing Xi Jinping's "herbal remedies" https://www.taiwannews.com.tw/en/news/3895540