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Chloroquine phosphate has shown apparent efficacy in treating Covid-19

ncbi.nlm.nih.gov

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Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#71

Post by ComputerGuru »

jshevek wrote: post #30
rrggrr wrote: post #28

Zinc. Chloroquine provides zinc and ionosphere for absorbtion that likely stops replicase.

Yes, I was reading about this recently. Another study compared zinc uptake into the cytosol for various extracellular zinc levels, with and without chloroquine. I noticed when looking at the data, that while chloroquine facilitated a massive uptake a zinc, it was still true that increasing the extracellular zinc concentration (without chloroquine) still increased the cytosol's zinc concentration (by a lesser amount).…

Just be sure to take it with food. A single tablet on an empty stomach will cause severe nausea; it’s a very heavy supplement.

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#72

Post by netsharc »

baybal2 wrote: post #59
dakom wrote: post #54

Earlier quoted context omitted.

So the real story is he proposed doing scientifically valid testing, which could easily disprove their efficacy - and that somehow turned into "the experiments give some hope for the treatment of the novel coronavirus" ... due to a bad English translation?

> ... due to a bad English translation? Not simply bad, but like a 180⁰ of the original meaning. Well, there is rich context to this. Chinese mainland media has been for weeks escalating the "herbal remedies" craze, and Xi somehow managed to insert himself even there. Now the media (propaganda ministry) can't back off, because Xi will look like an idiot if they are to back off and acknowledge how foolish it is. For Z…

https://www.economist.com/leaders/2017/08/31/china-is-rampin...

Apparently not just weeks, but for a long time.

Imagine if homeopathy became a point of something the government says we have to see as cultural/national pride. And is prescribed by doctors/hospitals because of that, and scientific analysis has to show the results that also reflect that...

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#73

Post by Anthony-G »

dakom wrote: post #50
baybal2 wrote: post #18

> • The outcomes of some current clinical trials of chloroquine in China have been announced, without access to the data. Shameless tangent, China has just booted its most competent respiratory disease epidemiologist from heading epidemic control committee for not backing Xi Jinping's "herbal remedies" https://www.taiwannews.com.tw/en/news/3895540

why does a search lead me to an article with the exact opposite story? http://www.china.org.cn/china/2020-02/19/content_75720773.ht...

To quote the article,

> TCM has never missed a single fight against epidemics throughout Chinese history. TCM classics have provided sufficient evidence of how TCM cured epidemic diseases such as smallpox over the past several thousand years.

I don't have any reason to trust an article from a Taiwanese publication over one from the PRC but the above quote leaves me highly sceptical about the rest of the article.

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#74

Post by bluGill »

pmorici wrote: post #56
tanilama wrote: post #43

Let us see how CDC will use this drug and do not make our own conclusions. If it helps it helps.

Because they did such a great job ramping up testing?

One would hope they have learned a lesson...

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#75

Post by bovermyer »

auntienomen wrote: post #61
_-___________-_ wrote: post #49

Earlier quoted context omitted.

Yeah, I remember reading something similar years ago. But I suspect with the proliferation of "craft tonic water" there may be some "flavours" that don't contain quinine at all. And 6L of tonic water is... quite a lot.

I read somewhere that gin & tonic was invented because they needed the gin to cover up the taste of the quinine, since the tonic needed to have a _lot_ of quinine to be effective. Shudder.

Here's a decent article on the history of gin and tonic: http://activehistory.ca/2012/08/gin-and-tonic-a-short-histor...

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#76

Post by internet_user »

allovernow wrote: post #24
saagarjha wrote: post #17

Earlier quoted context omitted.

What if the drug causes humans to die two weeks after taking it?

The alternative is drowning in your own body fluids after you're turned away by overwhelmed hospitals. Or watching it happen helplessly to your loved ones after they're turned away for being too old, as is happening in Italy. And in any case Chloroquine is a well studied, proven safe drug with minimal side effects and a high therapeutic ratio. Nanny states breed incompetence.

Therapeutic index of chloroquine isn't very high, and at the doses it's recommended for corona it's rather close to lethal doses, something like within an order of magnitude.

Malaria prophylaxis is dosed -once- a weeek. Half-life 60-70 hours. Covid treatment is -twice daily-.

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#77

Post by a_imho »

true_religion wrote: post #55
saagarjha wrote: post #17

Earlier quoted context omitted.

What if the drug causes humans to die two weeks after taking it?

Chloroquine is available without prescription in many West African counties, and is used liberally anytime a child has a fever. At this point, I would label it as dangerous as aspirin.

I understand there is probably no connection between the two sentences but to be clear as far as I know Aspirin is dangerous for children.

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#78

Post by DenisM »

khafra wrote: post #48
_-___________-_ wrote: post #42

Earlier quoted context omitted.

It's an analogue of quinine, which tonic water nowadays may contain varying (quite small) amounts of, depending on brand etc. G&Ts almost certainly won't have any effect on your susceptibility to infection nor your prognosis once infected. But they might help with (or make worse?) the anxiety associated with the panic.

Tonic water can contain up to 83mg/L actual quinine. Three 2L bottles of tonic water could get you 500mg, a therapeutic dose of quinine. Unfortunately, I have not found any place that manufacturers note how much quinine is in their tonic water.

You can also buy quinine pills online.

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#79

Post by empath75 »

_-___________-_ wrote: post #49
khafra wrote: post #48

Earlier quoted context omitted.

Tonic water can contain up to 83mg/L actual quinine. Three 2L bottles of tonic water could get you 500mg, a therapeutic dose of quinine. Unfortunately, I have not found any place that manufacturers note how much quinine is in their tonic water.

Yeah, I remember reading something similar years ago. But I suspect with the proliferation of "craft tonic water" there may be some "flavours" that don't contain quinine at all. And 6L of tonic water is... quite a lot.

You can boil it down presumably. Probably won’t taste very good though.

(I do not recommend this and am not a doctor)

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#80

Post by DenisM »

jshevek wrote: post #30
rrggrr wrote: post #28

Zinc. Chloroquine provides zinc and ionosphere for absorbtion that likely stops replicase.

Yes, I was reading about this recently. Another study compared zinc uptake into the cytosol for various extracellular zinc levels, with and without chloroquine. I noticed when looking at the data, that while chloroquine facilitated a massive uptake a zinc, it was still true that increasing the extracellular zinc concentration (without chloroquine) still increased the cytosol's zinc concentration (by a lesser amount).…

Can you quantify your findings? How much zinc do you think you will need, and how do you know that?

Also a link to the study would be helpful.

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