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US admits 'failing' on testing, says Fauci

bbc.com

21–30 of 85 posts

Re: US admits 'failing' on testing, says Fauci

#21
post #18
post #8

I thought this polymerase chain reaction test was something you could do at any university hospital?

From a technical perspective, it is a simple test. Hard part is chain of custody and sample integrity - controls, etc.

Are there any differences for Covid-19 samples versus any of the other samples such labs would be routinely testing though?

Re: US admits 'failing' on testing, says Fauci

#22
post #5

Admitting and identifying the problem is the first step. The Cleveland Clinic just came out with an 8 hour test and hopefully this will help the situation if they share the process. https://www.vox.com/science-and-health/2020/3/12/21175034/co...

There is nothing secret about RNA testing. Any decent lab can synthetise its own markers from a file downloaded from internet. It is like genetic research is illegal in US or what.

1) Regulatory issues

2) The reagents needed for the testing are also in extremely short supply, and labs are having a hard time getting more. So, you can develop a test, but your testing capacity will remain limited.

Re: US admits 'failing' on testing, says Fauci

#23
post #7

It’s so hard to trust the media to report on anything without trying to inflame the “orange man bad” narrative. In Australia almost no one with some or most of the symptoms is being tested. General Practitioners are basically telling people to fuck off, self isolate and call the hospital if symptoms worsen. https://apple.news/ASvoRONOWS9ijWX4RrGmiTQ “Currently we are not testing everyone, and whilst this may change i…

At what point does it become OK to point out that the "orange man" is, in fact, bad? Fox news and republican leaders spent weeks (weeks that we can't get back) trying to tell people that this wasn't a problem, that they shouldn't prepare, and that this was all a partisan argument against the president. And that was all wrong. It's real, it's happening, and we've lost critical time. That's bad, right? And it's bad in…

Especially since the article isn't about him. It mentions him twice, once citing the travel ban, another time quoting him as saying that we have good testing infrastructure (but noting that he did not elaborate). It does not describe him as "bad" or say anything directly negative. The article is about a high-level bureaucrat who says only "we".

The OP's comment is, unfortunately, indicative. The OP reads it as negative, and the reality is negative, but his primary concern is about the assignment of blame. In particular, assuring that it does not fall on him, and trying to shift it anywhere else. Meantime, the person actually cited in the article is trying to get something done -- which starts by admitting the there is a thing that needs to be done.

Re: US admits 'failing' on testing, says Fauci

#24

It’s so hard to trust the media to report on anything without trying to inflame the “orange man bad” narrative. In Australia almost no one with some or most of the symptoms is being tested. General Practitioners are basically telling people to fuck off, self isolate and call the hospital if symptoms worsen. https://apple.news/ASvoRONOWS9ijWX4RrGmiTQ “Currently we are not testing everyone, and whilst this may change i…

>In Australia almost no one with some or most of the symptoms is being tested. General Practitioners are basically telling people to fuck off, self isolate and call the hospital if symptoms worsen. This is simply false: >Here, testing is free and widely available, thanks to early and coordinated planning for a pandemic. On Thursday, Mr. Hanks said he and his wife had seen the efforts firsthand, as they tested positiv…

That’s Tom Hanks by the way. You don’t think he got preferential treatment?

Re: US admits 'failing' on testing, says Fauci

#25
I have a hard time faulting the CDC for the response overall, but I just don't understand why they decided to make their own test at the beginning. Was it bravado? Did they think the 70% accuracy of the WHO test wasn't good enough?

If they didn't make their own test, they wouldn't have fubarred the manufacturing, which would have given us more tests.

One of the CDC's main goals, if not the main goal in this, is to spread out the panic. Given this goal, the fact that we're in flu season, and the lack of test kits, I can understand the stringent testing criteria. They choose the best option in a bad situation, and I think they've done a pretty good job. However, it seems like a lot of problems could have been avoided if they just used the WHO tests.

Re: US admits 'failing' on testing, says Fauci

#26
post #4

Realistically there is no "US" any more. Fauci is speaking for the NIAID, and arguably for the scientific community within the CDC/NIH/HHS. The white house certainly wouldn't be on board with this message, but as we saw last night even the white house is inconsistent with its own policies in important ways. But yes: we messed up. We weren't prepared to begin with, we rolled back a bunch of existing preparedness work,…

Interestingly enough from another current HN article posting [1]: "I have read accounts in the press that Dr. [Anthony] Fauci isn't really allowed to speak until Mike Pence has approved his messaging."

Be interesting whether this is official or behind the WH's back, this BBC article doesn't have too many details.

[1] https://news.ycombinator.com/item?id=22556600

Re: US admits 'failing' on testing, says Fauci

#27
post #16

Earlier quoted context omitted.

There is nothing secret about RNA testing. Any decent lab can synthetise its own markers from a file downloaded from internet. It is like genetic research is illegal in US or what.

Offering a diagnostic test without FDA approval is illegal, for good reason (there would be companies far worse than Theranos) but clearly in an emergency regulators need to adapt.

That's not true for tests developed in the lab they are used in.

Re: US admits 'failing' on testing, says Fauci

#28
post #8

I thought this polymerase chain reaction test was something you could do at any university hospital?

It is, but there have been major bureaucratic delays, and no one was willing to step up and say "forget it, we are doing it". In addition, there have been shortages and/or problems with RNA extraction reagents/kits (this is a ssRNA virus) as well as viral nucleic acid sequence for positive control (positive control is critical for this type of testing).

Re: US admits 'failing' on testing, says Fauci

#29

Earlier quoted context omitted.

There is nothing secret about RNA testing. Any decent lab can synthetise its own markers from a file downloaded from internet. It is like genetic research is illegal in US or what.

1) Regulatory issues 2) The reagents needed for the testing are also in extremely short supply, and labs are having a hard time getting more. So, you can develop a test, but your testing capacity will remain limited.

Chloroform, phenol, and water are all availible in tanker car quantities.
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