Four important things to consider: First, this already happened to some extent. Outside of drives and fans, the virtually all of the power used in your system is exclusively 12v; either from the 12v pins on your ATX24 or P4 or EPS12 connectors, or via the PCI-E connectors; very little non-drive or non-fan power is supplied via 3.3 or 5v rails. Second, almost all PSUs today use 12v DC to 3.3/5v DC converters to increa…
I'm curious which fans don't use 12v - all the fans I know of in a typical computer operate on 12v except perhaps GPU fans. Occasionally I'll run a fan on 5v if I need it to be quieter and I don't have any PWM headers available, but that's about it.