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Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

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Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#191
post #168

Earlier quoted context omitted.

> If you have never entered ketosis and experienced your brain running on ketones, I would suggest you experiment for yourself. I would say a minimum 2-3 months which should be enough time for your microbiome to change and your body/brain to adapt primarily running on ketones. I've been on Keto for about 8 months (before giving up), measuring my blood ketones and being in deep ketosis between meals (over 2 mmol/L). I…

Why did you give up? How we your energy levels? Did you drop weight easily?

I gave up because I felt awful ... problems sleeping, strong heart palpitations, hair falling off, left foot going numb, etc... all symptoms of nutrient deficiencies, which I couldn't correct via food or with supplements and that started disappearing within a week after giving up.

And that entire time I did not lose weight, I actually gained a pound or two.

If you're interested in losing weight, find a strategy for eating less (by playing with what you eat or with meal timing). The only reason keto works for some people is because it leads to a spontaneous drop in appetite, due to cutting entire food groups from the diet, thus making the food you eat less palatable. And the extra protein sure helps. But it only works short term, after which you start enjoying bacon and butter, so the inevitable plateau happens and then you get the line about your metabolism needing to "heal" before losing weight, which is bullshit, as the causality is reversed (i.e. your metabolism is broken because you ate too much and exposed adipocytes tissue to an energy excess, aka energy poisoning, so the solution is to eat less and to lose weight).

I've lost 55 pounds and kept it off, being almost at my ideal weight. Not with keto.

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#192
I suffer from an inflammatory disorder and chronic TMD. I wrote my experience of switching to Keto here (this was 2.5 months in, I've stayed fairly strict Keto for nearly 2 years now) - https://medium.com/@iamnayr/2-5-months-on-the-ketogenic-diet...

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#193
post #87

I still don't understand the tech bro fascination with disordered eating.

I'm in the camp of you should do what works for you or what makes you happy (life-lengthening/hacking/whatever be damned), but any extensive reading I've done in trying to treat myself well has just brought me back to the same old information: balance and calories in < calories out.

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#194

The title is terrible, it should read ketosis/ketones may prevent, reverse age-related effects within the brain. "Low carb" as the title currently reads does not necessarily result in ketosis and your body/brain running on ketones, which appears to be the scope of this study. There is more to dietary ketosis than low carb, just as an example carnivore or paleo diets are low carb, but those will generally not result i…

> If you have never entered ketosis and experienced your brain running on ketones, I would suggest you experiment for yourself. I would say a minimum 2-3 months which should be enough time for your microbiome to change and your body/brain to adapt primarily running on ketones. I've been on Keto for about 8 months (before giving up), measuring my blood ketones and being in deep ketosis between meals (over 2 mmol/L). I…

> most people are in ketosis before eating breakfast in the morning, because the liver's glycogen is partially depleted overnight, enough for the liver to produce significant ketones. And nothing will make you enter ketosis faster like skipping a meal or two

There are two claims here that are pretty important and contrary to my understanding and experience: 1) Liver is depleted after usual sleep 2) Fasting is the fastest way to enter ketosis

Even when practicing a very low carb diet your liver is "topped up" through gluconeogenesis while you are sleeping.

If by ketosis you mean the body is producing enough ketones to power itself than the fastest way I know of kickstarting that process is not having carbs for 6 hours then going for a run or lifting heavy weights.

You don't need to starve yourself, you just need to put your body in a scenario where the energy demands overtake the available energy in the form of blood glucose (and strain the stores in the muscle and liver).

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#195

Sugar, not fat is the killer. Incredible how for decades bad research and the likes of Ancel Keys and Phil Sokolof put the health of millions at risk.

No one knows for sure yet. The most convincing theory I've heard is that it actually is fat...

But fat is an umbrella term. Saturated fat is (almost certainly) benign; eat as much (or as little) as you want.

Omega-6 and omega-3 polyunsaturated fats, on the other hand, are precursors to an important class of hormones called eicosanoids. If you eat too few, too much, or the wrong ratios, you will run into problems.

Our current diet is almost certainly way too high in omega-6 fats; the easy fix is just to stop eating vegetable oils.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492028/

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#196
post #117
post #102

Earlier quoted context omitted.

How does working out at a high intensity work when in a state of Ketosis? I lift weights and/or do HIIT 5x per week and occasionally add running on top of that. I've always been weary of going low carb or trying a keto diet because I feel like I just won't have the energy to continue my training regimen at its current intensity. The typical advice is to eat your allocated carbs 1-2 hours prior to your workout, howeve…

Don't go low-carb. There is no need, it's not unhealthy. Especially if you are sporty (as it sounds). The current state of affairs is: If you are insulin resistant (either because of genetics, obesity, whatever) then having a low-carb high fat diet is better for you. If your insulin resistance is high, then your pancreas produces much more insulin, meaning your cells will start storing energy instead of using it up.…

Are you familiar with Sami Inkinen?

https://www.youtube.com/watch?v=EKC9ZZ66jgc

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#197
post #102

The title is terrible, it should read ketosis/ketones may prevent, reverse age-related effects within the brain. "Low carb" as the title currently reads does not necessarily result in ketosis and your body/brain running on ketones, which appears to be the scope of this study. There is more to dietary ketosis than low carb, just as an example carnivore or paleo diets are low carb, but those will generally not result i…

How does working out at a high intensity work when in a state of Ketosis? I lift weights and/or do HIIT 5x per week and occasionally add running on top of that. I've always been weary of going low carb or trying a keto diet because I feel like I just won't have the energy to continue my training regimen at its current intensity. The typical advice is to eat your allocated carbs 1-2 hours prior to your workout, howeve…

Sami Inkonen and his SO rowed to Hawaii on a keto diet but were fat adapted first: https://www.youtube.com/watch?v

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#198

Is it too much to ask that anyone promoting low-carb based on personal experience post bloodwork? I think it's pretty clear no one on here is well-versed in nutrition as we're all programmers, so maybe it'd be good to have some intellectual integrity. I'm interested in prolactin, thyroid, liver, cholesterol, CO2.

I wanted to get bloodwork done to get some hard data, but I'm not sure which data points are the most important ones. Cholesterol and liver I understand, why prolactin, thyroid and CO2?

[deleted]

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#199
post #90
post #76

Earlier quoted context omitted.

In my personal case I'm not really able to enter and maintain good ketosis levels without also fasting intermittently. Intermittent fasting is key to enabling me to lower my caloric input because of the momentum of the fasting phase carried over into the eating phase, e.g. smaller stomach and more effective metabolism. I currently fast about 12 hours per day (including the sleep phase), which doesn't sound like much…

As an N of one, I present my situation: Since mid-January this year I have been fasting intemittently. I have zero calories before 5PM, and I am usually in bed by 10. I exercise most weeks between 4 and six days, but only two or so are "vigorous" for me. My workouts are mid-day. When I eat, I eat normally for me, which is lower carb and higher protein, but not (knowingly) keto or anything. I have lost about 10 pounds…

"I have zero calories before 5PM"

Did you mean after 5PM?

Other than weight loss, do you feel any differently (body, mind)? I have started IF last fall. Similar diet - low carb, higher protein. I also had considerable weight loss, but no impact on blood quality.

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#200
post #90

Earlier quoted context omitted.

As an N of one, I present my situation: Since mid-January this year I have been fasting intemittently. I have zero calories before 5PM, and I am usually in bed by 10. I exercise most weeks between 4 and six days, but only two or so are "vigorous" for me. My workouts are mid-day. When I eat, I eat normally for me, which is lower carb and higher protein, but not (knowingly) keto or anything. I have lost about 10 pounds…

Curious about your food choices. I've been experimenting with IF. More specifically I'd call it more like timed eating because the bulk of my fasting hours and during sleep. I'm down 20 lbs with solid numbers. As a side note I have some genetic factors as well and trying to counter those.

Same here, 10 kg down very quickly. Now weight is fixed at 80kg no matter what I eat. The only difference is when I eat.
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