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Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

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Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#171

Post by tvjunky »

dhimes wrote: post #90
ypcx wrote: post #76

Earlier quoted context omitted.

In my personal case I'm not really able to enter and maintain good ketosis levels without also fasting intermittently. Intermittent fasting is key to enabling me to lower my caloric input because of the momentum of the fasting phase carried over into the eating phase, e.g. smaller stomach and more effective metabolism. I currently fast about 12 hours per day (including the sleep phase), which doesn't sound like much…

As an N of one, I present my situation: Since mid-January this year I have been fasting intemittently. I have zero calories before 5PM, and I am usually in bed by 10. I exercise most weeks between 4 and six days, but only two or so are "vigorous" for me. My workouts are mid-day. When I eat, I eat normally for me, which is lower carb and higher protein, but not (knowingly) keto or anything. I have lost about 10 pounds…

Curious about your food choices. I've been experimenting with IF. More specifically I'd call it more like timed eating because the bulk of my fasting hours and during sleep. I'm down 20 lbs with solid numbers. As a side note I have some genetic factors as well and trying to counter those.

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#172

Post by wtetzner »

hanniabu wrote: post #122
riku_iki wrote: post #74

Earlier quoted context omitted.

You need to add some butter, oil and heavy cream, or chances are you are not in ketosis: 80% of you calories intake should come from fat to guarantee ketosis.

Olive oil. Lots of olive oil.

Yep. But you're probably better off cooking with something like coconut oil, and just pouring the olive oil on your food.

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#173

Post by uberduper »

throwaway_tech wrote: post #17

The title is terrible, it should read ketosis/ketones may prevent, reverse age-related effects within the brain. "Low carb" as the title currently reads does not necessarily result in ketosis and your body/brain running on ketones, which appears to be the scope of this study. There is more to dietary ketosis than low carb, just as an example carnivore or paleo diets are low carb, but those will generally not result i…

> in protein rich diets your body will convert the protein to glucose which will continue to be the primary fuel for the cells in the brain/body.

This is completely incorrect. Gluconeogenesis is stimulated by the pancreas releasing glucagon in response to low blood sugar. GNG happens in everyone regardless of diet when blood sugar is too low. It has nothing at all to do with the amount of dietary protein you consume.

GNG happens in people in ketosis pretty constantly without stopping ketosis.

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#174

Post by throwaway_tech »

bad_user wrote: post #149
throwaway_tech wrote: post #17

The title is terrible, it should read ketosis/ketones may prevent, reverse age-related effects within the brain. "Low carb" as the title currently reads does not necessarily result in ketosis and your body/brain running on ketones, which appears to be the scope of this study. There is more to dietary ketosis than low carb, just as an example carnivore or paleo diets are low carb, but those will generally not result i…

> If you have never entered ketosis and experienced your brain running on ketones, I would suggest you experiment for yourself. I would say a minimum 2-3 months which should be enough time for your microbiome to change and your body/brain to adapt primarily running on ketones. I've been on Keto for about 8 months (before giving up), measuring my blood ketones and being in deep ketosis between meals (over 2 mmol/L). I…

>Also most people are in ketosis before eating breakfast in the morning, because the liver's glycogen is partially depleted overnight

This is true...but it gets to my point, just because your body begins breaking down fat and producing ketones (as shown in your tests) does not mean your cells have adapted to using ketones as fuel, that requires the body to adapt.

Based on your numbers you were clearly breaking down fat and making ketones, but based on your not feeling any different I'd say your cells never adapted to ketones as the primary fuel source. This is the same for people depleting their glucose stores over night, yes they are in "ketosis", meaning they are breaking down fat and producing ketones, but that does not mean their cells are efficiently running on ketones.

My guess with you, not knowing more, is you are pretty inactive. At least I would be surprised to learn you engage in lets say an hour of cardio 4-5 times a week. I am not saying keto is the end all be all, or that everyone prefers it, but I have not met anyone who does aerobic cardio and experimented with Ketosis and not experienced a different (again good or bad). On the other hand I have met many people who tried Keto and never noticed any difference, like you describe, and the commonality seems to be they were inactive.

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#175

Post by achenatx »

ebg13 wrote: post #113
skizm wrote: post #102

Earlier quoted context omitted.

How does working out at a high intensity work when in a state of Ketosis? I lift weights and/or do HIIT 5x per week and occasionally add running on top of that. I've always been weary of going low carb or trying a keto diet because I feel like I just won't have the energy to continue my training regimen at its current intensity. The typical advice is to eat your allocated carbs 1-2 hours prior to your workout, howeve…

> How does working out at a high intensity work when in a state of Ketosis? I've done this. You get tired much faster, you will not be able to sprint for nearly as long, your maximum lift significantly decreases, you hit the muscle fatigue point (can't lift again unless you lower the weight) very quickly. The usual solution among keto lifters is to have a carbload cheat day once per week _or_ to carb spike with I thi…

this was my experience. My endurance was unaffected by ketosis but my ability to generate instant power over and over again (mountain bike) definitely took a hit.

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#176

Post by amanaplanacanal »

teilo wrote: post #165
throwaway_tech wrote: post #17

The title is terrible, it should read ketosis/ketones may prevent, reverse age-related effects within the brain. "Low carb" as the title currently reads does not necessarily result in ketosis and your body/brain running on ketones, which appears to be the scope of this study. There is more to dietary ketosis than low carb, just as an example carnivore or paleo diets are low carb, but those will generally not result i…

It is true that ketosis is more than low carb, but Gluconeogensis has absolutely nothing to do with it. There is a lot of wrong information out there about GNG. GNG is an on-demand production of glucose, and absolutely does NOT kick the body out of ketosis, or cause the brain to run on glucose. GNG provides enough glucose for the tissues that cannot run on ketones (such as the kidneys). Without GNG, ketosis would not…

Thank you! I see claims all the time that eating too much protein will kick you out of ketosis, without any actual science to back it up.

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#177

Post by wtetzner »

tejohnso wrote: post #18

Noted that the underlying cause for the improvement comes from ketones. This should indicate that intermittent fasting would also show similar results. Low carb diet, keto diet, intermittent fasting, they're all just different ways to switch the fuel source from glucose to ketones.

Yep. But ketosis and intermittent fasting are complementary. It's just sooooo much easier to fast when in ketosis.

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#178

Post by wtetzner »

newscracker wrote: post #22
tejohnso wrote: post #18

Noted that the underlying cause for the improvement comes from ketones. This should indicate that intermittent fasting would also show similar results. Low carb diet, keto diet, intermittent fasting, they're all just different ways to switch the fuel source from glucose to ketones.

Would a time restricted feeding type of intermittent fasting, with a 16/8 schedule, really result in the production of ketones? I thought that it would take about a day and a half or longer to exhaust carbs and start the switch to ketones. Then it’s only the longer fasts (like 5/2 days) that could help.

The easiest way to tell is to actually test your blood: https://www.amazon.com/gp/product/B0789G8KTG/

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#179

Post by wtetzner »

florin0x01 wrote: post #88

How about weight training and low carb and sometimes IF? Would weight training prevent age related effects within the brain? Also you can't go full keto if you also want weight training, imo.

> Also you can't go full keto if you also want weight training, imo.

You absolutely can, and people are doing it just fine.

Check out Metabolic Autophagy: https://www.amazon.com/Metabolic-Autophagy-Intermittent-Resi...

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#180

Post by pengaru »

cageface wrote: post #134
wirrbel wrote: post #111

Earlier quoted context omitted.

Meat also raises insulin, much less than carbs, but on a carnivore diet I can imagine this to happen. The keto diet with ratios has been designed as a diet for epileptics, so in a ratio that maintains both body weight in a healthy range and induces ketosis and avoids ceizures (note: 1920s medicine or something). So the high fat content kind of is there to actually give you the energy so that you don't loose weight. O…

Meat raises insulin levels significantly. A steak spikes your insulin harder than a plate of spaghetti.

They're pretty close according to https://en.wikipedia.org/wiki/Insulin_index

"White pasta" 40 ±5 vs. "Beef" 51 ±16

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