Live data from Hacker News

Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

news.stonybrook.edu

161–170 of 343 posts

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#161
post #30

Sugar, not fat is the killer. Incredible how for decades bad research and the likes of Ancel Keys and Phil Sokolof put the health of millions at risk.

Is this definite and scientific consensus? Nutrition research seems to change as often as JavaScript framework of the month. I saw one Ted talk that essentially said "everyone is different and no rules apply to everyone".

> Is this definite and scientific consensus?

No. But some people like simple answers. Truth is: It's complicated and nutrition researchers are nowhere near any consensus on these questions.

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#162

IF has really saved my life. I definitely feel like i reverse aged a few years as a result of it. I enjoy food more now, weight is in check, I look younger.. hard to beat the benefits.

What's your regimen? Do you restrict what kinds of food you eat? What about alcohol? I've been interested in starting it.

Mostly plant based (occasional pizza or gelato maybe once a month), I do alternate day fasting, something like 40:8, fast 40 hours eat for 8.. try to avoid night eating, it makes me feel worse the next day.. maybe a bit much for some but I feel so much stronger as a result. Low caffeine.. probably too much fake meat/soy products for my own good..

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#163

Is it too much to ask that anyone promoting low-carb based on personal experience post bloodwork? I think it's pretty clear no one on here is well-versed in nutrition as we're all programmers, so maybe it'd be good to have some intellectual integrity. I'm interested in prolactin, thyroid, liver, cholesterol, CO2.

I wanted to get bloodwork done to get some hard data, but I'm not sure which data points are the most important ones. Cholesterol and liver I understand, why prolactin, thyroid and CO2?

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#164
post #45

Earlier quoted context omitted.

The real issue is that nutrition science is bad and everyone has a book. Maybe 1 in 20 studies don't have obvious confounding factors that cause us to have no real base facts, but we can find a lot of correlation. Unfortunately, this is kind of the nature of the beast, nutrition science isn't bad because nutrition scientists are bad, but rather because it's so complicated it's tough to have very clean data. Demonizin…

The government may have been advocating low fat diets but of course people don't follow nutrition advice. If you look at what people were actually eating in the time you describe they started eating more of everything. Consumption of chicken and cheese in particular exploded. Sugar consumption has actually been in decline for years now and obesity keeps climbing. Yes sugar is bad for you but blaming modern health pro…

> Sugar consumption has actually been in decline for years now and obesity keeps climbing.

Do you have a source for this? Because it seems like unless you cook your own food, it's nearly impossible to avoid foods that have _added_ sugar these days. Maybe sugar consumption has increased, but it's less obvious now.

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#165

The title is terrible, it should read ketosis/ketones may prevent, reverse age-related effects within the brain. "Low carb" as the title currently reads does not necessarily result in ketosis and your body/brain running on ketones, which appears to be the scope of this study. There is more to dietary ketosis than low carb, just as an example carnivore or paleo diets are low carb, but those will generally not result i…

It is true that ketosis is more than low carb, but Gluconeogensis has absolutely nothing to do with it. There is a lot of wrong information out there about GNG.

GNG is an on-demand production of glucose, and absolutely does NOT kick the body out of ketosis, or cause the brain to run on glucose. GNG provides enough glucose for the tissues that cannot run on ketones (such as the kidneys). Without GNG, ketosis would not be possible. In fact, ketones regulate GNG, and prevent it from exceeding the needed maintenance levels.

Furthermore, GNG runs at mostly a constant level, does not increase with protein intake, and is at that constant level even when the body is not in ketosis.

What prevent ketosis in stubborn cases? Insulin resistance. To overcome insulin resistance it takes a strict low-carb regime paired with moderate fat intake, and lowering of stress. The process can be dramatically sped up with intermittent fasting.

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#166
Well here I am again. Here are things I think people should know:

Gluconeogenisis does not kick you out of ketosis nor is it’s existence a counter-point to the keto diet.

I have first hand experience with keto and psychosis. I experienced something traumatic a while ago and began to have psychotic symptoms similar to schizophrenia. I had read an article beforehand written by a doctor claiming that keto benefited his psych patients, so I tried it. It cured me. Most symptoms gone in a couple days, total remission within a couple weeks. So PSA: if you or someone you know is having problems with psychotic mental health problems, keto may help you.

And I should add I was formally diagnosed with psychosis and prescribed antipsychotics. And the symptoms correlated perfectly with going on and off keto. Very little ambiguity. They are doing a study on this in Finland but results won’t be out till December.

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#167

The title is terrible, it should read ketosis/ketones may prevent, reverse age-related effects within the brain. "Low carb" as the title currently reads does not necessarily result in ketosis and your body/brain running on ketones, which appears to be the scope of this study. There is more to dietary ketosis than low carb, just as an example carnivore or paleo diets are low carb, but those will generally not result i…

> If you have never entered ketosis and experienced your brain running on ketones, I would suggest you experiment for yourself. I would say a minimum 2-3 months which should be enough time for your microbiome to change and your body/brain to adapt primarily running on ketones. I've been on Keto for about 8 months (before giving up), measuring my blood ketones and being in deep ketosis between meals (over 2 mmol/L). I…

This depends a lot on the individual. I would suggest it to anyone who often has post-meal slumps, for example - its likely to work wonders for them.

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#168

The title is terrible, it should read ketosis/ketones may prevent, reverse age-related effects within the brain. "Low carb" as the title currently reads does not necessarily result in ketosis and your body/brain running on ketones, which appears to be the scope of this study. There is more to dietary ketosis than low carb, just as an example carnivore or paleo diets are low carb, but those will generally not result i…

> If you have never entered ketosis and experienced your brain running on ketones, I would suggest you experiment for yourself. I would say a minimum 2-3 months which should be enough time for your microbiome to change and your body/brain to adapt primarily running on ketones. I've been on Keto for about 8 months (before giving up), measuring my blood ketones and being in deep ketosis between meals (over 2 mmol/L). I…

Why did you give up? How we your energy levels? Did you drop weight easily?

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#169
post #86

I’m confused because I thought the brain liked sugars: “The bold implication of this idea is that the effects of ego depletion could be undone by ingesting glucose, and Baumeister and his colleagues have confirmed this hypothesis in several experiments.” Kahneman, D. “Thinking, Fast and Slow”. 2011. pg. 43, para. 2, Se. 5.

Ego Depletion is junk science which hasn't reproduced in serious experiments.

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#170
post #113
post #102

Earlier quoted context omitted.

How does working out at a high intensity work when in a state of Ketosis? I lift weights and/or do HIIT 5x per week and occasionally add running on top of that. I've always been weary of going low carb or trying a keto diet because I feel like I just won't have the energy to continue my training regimen at its current intensity. The typical advice is to eat your allocated carbs 1-2 hours prior to your workout, howeve…

> How does working out at a high intensity work when in a state of Ketosis? I've done this. You get tired much faster, you will not be able to sprint for nearly as long, your maximum lift significantly decreases, you hit the muscle fatigue point (can't lift again unless you lower the weight) very quickly. The usual solution among keto lifters is to have a carbload cheat day once per week _or_ to carb spike with I thi…

Can you take vitamins like B complex with electrolytes and sugar free, no carb protein shakes with caffeine to get some energy back?
Post reply on HN