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Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

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Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#151

Post by lhl »

skizm wrote: post #102
throwaway_tech wrote: post #17

The title is terrible, it should read ketosis/ketones may prevent, reverse age-related effects within the brain. "Low carb" as the title currently reads does not necessarily result in ketosis and your body/brain running on ketones, which appears to be the scope of this study. There is more to dietary ketosis than low carb, just as an example carnivore or paleo diets are low carb, but those will generally not result i…

How does working out at a high intensity work when in a state of Ketosis? I lift weights and/or do HIIT 5x per week and occasionally add running on top of that. I've always been weary of going low carb or trying a keto diet because I feel like I just won't have the energy to continue my training regimen at its current intensity. The typical advice is to eat your allocated carbs 1-2 hours prior to your workout, howeve…

There is a keto adaptation [1] period of at least 6-8 weeks where you might take a hit, but there are several studies that show that it's generally not a concern.

Cipryan, Lukas, Daniel J. Plews, Alessandro Ferretti, Phil B. Maffetone, and Paul B. Laursen. “Effects of a 4-Week Very Low-Carbohydrate Diet on High-Intensity Interval Training Responses.” Journal of Sports Science & Medicine 17, no. 2 (May 14, 2018): 259–68.

Greene, David A., Benjamin J. Varley, Timothy B. Hartwig, Phillip Chapman, and Michael Rigney. “A Low-Carbohydrate Ketogenic Diet Reduces Body Weight Without Compromising Performance in Powerlifting and Olympic Weightlifting Athletes.” The Journal of Strength & Conditioning Research Publish Ahead of Print (October 17, 2018). https://doi.org/10.1519/JSC.0000000000002904.

Paoli, Antonio, Keith Grimaldi, Dominic D’Agostino, Lorenzo Cenci, Tatiana Moro, Antonino Bianco, and Antonio Palma. “Ketogenic Diet Does Not Affect Strength Performance in Elite Artistic Gymnasts.” Journal of the International Society of Sports Nutrition 9 (July 26, 2012): 34. https://doi.org/10.1186/1550-2783-9-34.

Kephart, Wesley C., Coree D. Pledge, Paul A. Roberson, Petey W. Mumford, Matthew A. Romero, Christopher B. Mobley, Jeffrey S. Martin, et al. “The Three-Month Effects of a Ketogenic Diet on Body Composition, Blood Parameters, and Performance Metrics in CrossFit Trainees: A Pilot Study.” Sports 6, no. 1 (January 9, 2018). https://doi.org/10.3390/sports6010001.

If you're interested in the topic of human performance and ketosis, I enjoy Volek's talks - here's one from a relatively recent Jumpstart event: https://www.youtube.com/watch?v=BeS_dhM8dsY

Anecdotally, I find my workout recovery to be much better on keto/fasting diet, but all my markers (and overall inflammation) has improved so much and I'm being mindful of other aspects like stress, sleep, etc that it's hard to necessarily pin down to one cause.

[1] https://blog.virtahealth.com/keto-adapted/

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#152

Post by riku_iki »

tokamak-teapot wrote: post #136
riku_iki wrote: post #74

Earlier quoted context omitted.

You need to add some butter, oil and heavy cream, or chances are you are not in ketosis: 80% of you calories intake should come from fat to guarantee ketosis.

This is a popular misconception. Please check the [1] keto FAQ on Reddit. [1] https://www.reddit.com/r/keto/wiki/faq#wiki_how_do_i_start_a...

Reading that FAQ, the idea behind low fat intake is that body will provide fat, which means you need to have some high calories restrictions to initiate process.

E.g. you need 2k calories for your day-to day life. If you don't want to eat lots of fat, to get into ketosis you need to decrease your food intake to say 1k, with idea is that 0.05k calories will come from carbs in food, say 0.2k calories will come from protein in food, 0.75k calories will come from fat in food, and another 1k will come from body fat.

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#153

Post by ryanSrich »

rconti wrote: post #142
throwaway_tech wrote: post #17

The title is terrible, it should read ketosis/ketones may prevent, reverse age-related effects within the brain. "Low carb" as the title currently reads does not necessarily result in ketosis and your body/brain running on ketones, which appears to be the scope of this study. There is more to dietary ketosis than low carb, just as an example carnivore or paleo diets are low carb, but those will generally not result i…

Anything that requires me to radically change my diet to experiment with myself "just to see", that takes a minimum of 2-3 months, is a hard pass. It's just not that interesting to most of us for a vaguely hand-wavey possibly useful experiment.

Full-on keto may not be worth it, but I would highly suggest removing most carbs from your diet (<= 30g per meal). You'll feel completely different within 5 days. This is especially noticeable after the age of 30. I have no scientific backing or research for this, but I've had a number of friends and family make this small change and every single one has not gone back. It's not even that difficult if you already have a somewhat healthy diet.

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#154

Post by jvanderbot »

collyw wrote: post #29
throwaway_tech wrote: post #17

The title is terrible, it should read ketosis/ketones may prevent, reverse age-related effects within the brain. "Low carb" as the title currently reads does not necessarily result in ketosis and your body/brain running on ketones, which appears to be the scope of this study. There is more to dietary ketosis than low carb, just as an example carnivore or paleo diets are low carb, but those will generally not result i…

I was about to ask if intermittent fasting would have the same effects as I get the impression that its a healthier way of getting into ketosis. (When I look, I don't see negative effects associated with IF, and I do with keto diets. The research changes a lot and the conclusions don't seem definitive, but I thought someone on here might have an educated opinion on the matter).

Yes. Perhaps stronger effects w IF, according to this.

https://www.businessinsider.com/fasting-diet-ketosis-brain-b...

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#155

Post by wtetzner »

whiddershins wrote: post #115
throwaway_tech wrote: post #17

The title is terrible, it should read ketosis/ketones may prevent, reverse age-related effects within the brain. "Low carb" as the title currently reads does not necessarily result in ketosis and your body/brain running on ketones, which appears to be the scope of this study. There is more to dietary ketosis than low carb, just as an example carnivore or paleo diets are low carb, but those will generally not result i…

I would like a citation on the protein to glucose claim. My understanding is the body would much rather run on ketones than go down that path.

My understanding is that the body will convert protein to Glucose when needed, but it is very carefully regulated, and will prefer ketones for cells that can run on them. However, some cells require glucose, and gluconeogenesis is important for that if you're eating low carb/in ketosis.

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#156

Post by wtetzner »

letharion wrote: post #106
pc86 wrote: post #65

Earlier quoted context omitted.

This[0] is a good starting point. Dietary protein can readily be converted to glucose in the body and either stored as fat or used as energy. [0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636610/

The article says in multiple places that in practice, little of the protein was converted to glucose.

Yes, my understanding is that it will only convert as much as it needs to support the parts of the body that actually require glucose to run.

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#157

Post by [deleted] »

hoka-one-one wrote: post #148

Is it too much to ask that anyone promoting low-carb based on personal experience post bloodwork? I think it's pretty clear no one on here is well-versed in nutrition as we're all programmers, so maybe it'd be good to have some intellectual integrity. I'm interested in prolactin, thyroid, liver, cholesterol, CO2.

[deleted]

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#158

Post by lukifer »

nickbauman wrote: post #123

A lot of folks here are using the term "intermittent fasting". This is a term that can make people struggling with eating disorders kinda lose their minds. May suggest to replace this term with what's probably a better way of saying it anyway, because it's more accurate to what people are really doing when they say IF: Call it "time-restricted eating" . You're eating the food you eat for a day in a smaller window. No…

There is some correlation between the benefits of "time-restricted eating" and full-blown fasting (autophagy, etc), so it makes some sense to talk about them similarly. There are many benefits to full water fasts, even for 2-3 days (and it's much easier to do successfully if one is already in ketosis). See the work of Dr. Jason Fung: https://thefastingmethod.com/

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#159

Post by cies »

throwaway_tech wrote: post #17

The title is terrible, it should read ketosis/ketones may prevent, reverse age-related effects within the brain. "Low carb" as the title currently reads does not necessarily result in ketosis and your body/brain running on ketones, which appears to be the scope of this study. There is more to dietary ketosis than low carb, just as an example carnivore or paleo diets are low carb, but those will generally not result i…

Afaik there is no top athlete on keto when performing: they are all on high-carb.

Keto is the "burn your body fat" mode. Staying in keto by eating high fat low carb is a trick. Humans never had such easy access to fats as today. Before we made settlements we got a large part of our calories from fruits (which contain short carbs), not unlike the other primates.

Re: Study: Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

#160

Post by [deleted] »

[deleted] wrote: post #157
hoka-one-one wrote: post #148

Is it too much to ask that anyone promoting low-carb based on personal experience post bloodwork? I think it's pretty clear no one on here is well-versed in nutrition as we're all programmers, so maybe it'd be good to have some intellectual integrity. I'm interested in prolactin, thyroid, liver, cholesterol, CO2.

[deleted]

[deleted]
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