61–70 of 85 posts
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Isn't blood pretty good at this?
I'm not a biologist but I suppose that not every kind of protein enters any kind of cell.
https://en.wikipedia.org/wiki/Coronavirus#/media/File:3D_med... [the N protein is supposedly the nucleocapsid, which is basically/maybe another envelope around the RNA]
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I happened to work in the lab at the University of Washington that helped maintain the game as an undergrad. Here's a published scientific article about the use of Foldit for science: https://www.nature.com/articles/nature09304 (I'm not disagreeing that the website is badly designed.)
Thanks. I’d quibble about the design word... the design is ok; it’s the wording that is lacking. Or some clear thinking. I mean for all the effort they are spending on this, it would take like one paragraph or less to clear things up. It could be fixed with five minutes of effort.
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Deliver mRNA, or a protein?
both or either dependent on the therapeutic strategy. this is also something that is not limited to corona virus, this is the basis of a recombinant vaccine that can be adjusted for any antigen.
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Thanks. I’d quibble about the design word... the design is ok; it’s the wording that is lacking. Or some clear thinking. I mean for all the effort they are spending on this, it would take like one paragraph or less to clear things up. It could be fixed with five minutes of effort.
Design encompasses everything that people interact with, so words are part of design. In fact there's a whole discipline called "User Experience Writing".
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both or either dependent on the therapeutic strategy. this is also something that is not limited to corona virus, this is the basis of a recombinant vaccine that can be adjusted for any antigen.
Cool. I was thinking about immunotherapy like IL proteins.. sometimes they are injected and sometimes infused, I don't know why.
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That's a big wall of text, with some nice ideas about how efficient markets are the solution to the problem, but you fail to realize that the US has a sub-par medical system (life expectancy is lagging quite far from most European countries) while being twice as costly as the OECD mean per capita.
I understand why people use this talking point. It's easy to say and the reasons why it's nonsense involve details. You can't compare life expectancy without accounting for cultural or geographic differences. The US has a higher rate of motor vehicle fatalities (as a result of driving more), more suicides and drug overdoses etc. These bring down life expectancy because they disproportionately impact the young. The US…
Strange site. The heading implies that they are attempting to design things that help science, but if you drill in to the pages for "new to fold.it" and FAQ, it never actually says that any of the results are used by anyone. Instead it says that it's all a game and the only science goal is to prove that humans are capable (just like computers) of doing this. I wonder if this is really all it is, or if the writers of…
I know it's fun, and I think participative science is such a huge shift in paradigm … But considering the global impact of coronavirus, I'm wondering if there shouldn't be a better way to fund this type of endeavor. Any cloud provider willing to donate compute to researchers?
fold.it is a lot more about the fact that humans still are a lot better at exploring complex spaces than computers. Analysis of results has shown players reaching semi-global minima in folding space much quicker than computers and designing novel folds that express and crystallize that have not been seen in nature before (which means they can explore more space than starting from known templates). Researchers are try…
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That's a big wall of text, with some nice ideas about how efficient markets are the solution to the problem, but you fail to realize that the US has a sub-par medical system (life expectancy is lagging quite far from most European countries) while being twice as costly as the OECD mean per capita.
I understand why people use this talking point. It's easy to say and the reasons why it's nonsense involve details. You can't compare life expectancy without accounting for cultural or geographic differences. The US has a higher rate of motor vehicle fatalities (as a result of driving more), more suicides and drug overdoses etc. These bring down life expectancy because they disproportionately impact the young. The US…
This is interesting, can you provide a source for this?
Agreed on all other counts.
