Earlier quoted context omitted.
this is the mechanism a coronavirus assembly exploits to enter a cell. the virion uses a peplomer [one of its spikes] to dock with the cell at the ACE2 receptor then wrenches it apart like cutting a door right out of its frame, then the virus inserts itself into the cell leaving its envelope and protien accessories fused with the cell membrane. -if this mechanism can be blocked it will inhibit viral entry -if it can…
Sorry I don't know much about the topic. How can I find out if I have too high (?) ACE2, and what can I do about it? Are there sympthoms at least?
Angiotensin converting enzyme 2 (ACE2) crucial in SARS-coronavirus lung injury (2005)
21–30 of 57 posts
Re: Angiotensin converting enzyme 2 (ACE2) crucial in SARS-coronavirus lung injury (2005)
#22Earlier quoted context omitted.
Another interesting side effect could be other temporizing measures in the inpatient setting. My understanding from a brief skim of older research papers is that the ACE inhibitors and angiotensin receptor blockers that we use today, like lisinopril or losartan, could upregulate the expression of ACE-2 receptors. If a patient is admitted with coronavirus, discontinuing blood pressure medications such as lisinopril an…
Can you please give me a pointer on these researches? Also its not clear to me: do blood pressure mediacations in general upregulate the expression of ACE-2, or is it possible that they downregulate it? (Not lisonopril or losartan)
you can do both depending on the med and there are different mechanisms of action.
Also :
any sort of EXPERIMENTATION should be done in a clinical setting with qualified professionals,
this discussion is about scientific research and is not even close to being acceptable for clinical trials.
blood pressure medication is normally prescribed with physician monitoring the patient for desirable or undesirable effect
Re: Angiotensin converting enzyme 2 (ACE2) crucial in SARS-coronavirus lung injury (2005)
#23Can we get a (2005)?
Re: Angiotensin converting enzyme 2 (ACE2) crucial in SARS-coronavirus lung injury (2005)
#24Can we get a (2005)?
there is a difference between tech and science with regard to correlations between recency and quality.
Scientific articles gain credibility as they age and no known exception to elucidated principles is apparent.
in this case the [2005] article is superior to a [2020] article.
i do agree however it is helpful and conventional to include a date of publication
Re: Angiotensin converting enzyme 2 (ACE2) crucial in SARS-coronavirus lung injury (2005)
#25That's a quite old (2005) article, dating to the original sars outbreak. https://www.biorxiv.org/content/10.1101/2020.01.26.919985v1 is a much more recent one, specific to covid-19. (Edit typo)
That particular preliminary linked to is too new and requires critical interpretation for a number of issues
> is too new
it's on bioarxiv, what exactly does 'too new' mean?
Re: Angiotensin converting enzyme 2 (ACE2) crucial in SARS-coronavirus lung injury (2005)
#26__This is not medical advice. Do not go out and take a bunch of losartan without a doctor, you could die.__
Here's the article's main point (from 2005): Kuba et al showed that by injecting losartan into mice (a common ACE inhibitor that is off patent) with a SARS-Coronavirus protein leads to less lung injury than the controls without losartan. No studies have shown this works in living, breathing humans, but...
(Oral) losartan is widely available (at least right now), it can be prescribed off-label by doctors and picked up today. As its on-label use is treating hypertension, obviously it will lead to low blood pressure, along with all the other possible side effects including life-threatening swelling and more. And since dehydration and sepsis can also lead to lower blood pressure, you'd be playing with fire in life-threatening ways without careful watch by a doctor. You can bet this is a source of ongoing research and trials, probably already underway.
__This is not medical advice. Do not go out and take a bunch of losartan without a doctor, you could die.__
Re: Angiotensin converting enzyme 2 (ACE2) crucial in SARS-coronavirus lung injury (2005)
#27ARB stands for AT1R blockers ( angiotensin II type one ) and they represent a major class of antihypertensive medications. These drugs end in sartan.
They will not block ACE2 which is a protein which gets expressed in the lung tissues.
Please Do not get carried away. https://en.wikipedia.org/wiki/Angiotensin-converting_enzyme_...
Re: Angiotensin converting enzyme 2 (ACE2) crucial in SARS-coronavirus lung injury (2005)
#28One of the most popular blood pressure medications, Lisinopril, is an ACE inhibitor. A lot of people worldwide (including myself) take it daily. Its mechanism of action is to prevent the conversion of ACE to ACE2.
Lisinopril is a competitive inhibitor of ACE that prevents it from converting Angiotensin I to Angiotensin II
Re: Angiotensin converting enzyme 2 (ACE2) crucial in SARS-coronavirus lung injury (2005)
#29Earlier quoted context omitted.
That particular preliminary linked to is too new and requires critical interpretation for a number of issues
> is too new it's on bioarxiv, what exactly does 'too new' mean?
a preliminary submission has not passed a peer review with the rigor of scientific defense.
these sorts of things may be passed among researchers for extended periods of time [years] until all the kinks are worked out of the thesis and a working theory with no known exceptions and independently confirmed agreement of results occurs.
jan 26 2020 is the submission date.
Re: Angiotensin converting enzyme 2 (ACE2) crucial in SARS-coronavirus lung injury (2005)
#30Earlier quoted context omitted.
this is the mechanism a coronavirus assembly exploits to enter a cell. the virion uses a peplomer [one of its spikes] to dock with the cell at the ACE2 receptor then wrenches it apart like cutting a door right out of its frame, then the virus inserts itself into the cell leaving its envelope and protien accessories fused with the cell membrane. -if this mechanism can be blocked it will inhibit viral entry -if it can…
Another interesting side effect could be other temporizing measures in the inpatient setting. My understanding from a brief skim of older research papers is that the ACE inhibitors and angiotensin receptor blockers that we use today, like lisinopril or losartan, could upregulate the expression of ACE-2 receptors. If a patient is admitted with coronavirus, discontinuing blood pressure medications such as lisinopril an…
Lisinopril and losartan are usually stopped in patients admitted to the hospital for an infection.