Post-intensive care syndrome results from continuous inflammation
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Post-intensive care syndrome results from continuous inflammation
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Re: Post-intensive care syndrome results from continuous inflammation
#2This topic is interesting to me for a few reasons...
Cognitive impairment has long been associated with inflammation in older adults: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390758/
As well as the general population where illness is involved: https://psychcentral.com/news/2019/12/01/inflammation-linked...
And it contributes to a variety of disorders (potentially almost all of them). The research here is pretty broad, Google if interested. Notably, depression, anxiety and other behavior impacting problems are among the aforementioned disorders.
We know that exercise levels and diet can lower or increase inflammation.
So we have this sort of rare magic bullet when it comes to health, cognition and aging. Lowering inflammation won't fix everything of course, but it will lower your risk of pretty much everything.
And yet this truth is less a part of the zeitgeist than you'd expect, given it's impact. Maybe because it's simple but not easy to change your lifestyle. Or more importantly, the lifestyles of a population. Especially when part of the problem is financial insecurity.
Re: Post-intensive care syndrome results from continuous inflammation
#3This topic is interesting to me for a few reasons... Cognitive impairment has long been associated with inflammation in older adults: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390758/ As well as the general population where illness is involved: https://psychcentral.com/news/2019/12/01/inflammation-linked... And it contributes to a variety of disorders (potentially almost all of them). The research here is pretty…
Big part of the problem is that inflammation is beneficial, only chronic inflammation is a problem. But treatments would reduce both.
Re: Post-intensive care syndrome results from continuous inflammation
#4This topic is interesting to me for a few reasons... Cognitive impairment has long been associated with inflammation in older adults: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390758/ As well as the general population where illness is involved: https://psychcentral.com/news/2019/12/01/inflammation-linked... And it contributes to a variety of disorders (potentially almost all of them). The research here is pretty…
Big part of the problem is that inflammation is beneficial, only chronic inflammation is a problem. But treatments would reduce both.
> Big part of the problem is that inflammation is beneficial, only chronic inflammation is a problem.
But what about anaphylaxis, hay fever, mild allergies etc. There are plenty of acute or non-chronic inflammatory conditions that are a problem.
Re: Post-intensive care syndrome results from continuous inflammation
#5This topic is interesting to me for a few reasons... Cognitive impairment has long been associated with inflammation in older adults: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390758/ As well as the general population where illness is involved: https://psychcentral.com/news/2019/12/01/inflammation-linked... And it contributes to a variety of disorders (potentially almost all of them). The research here is pretty…
Big part of the problem is that inflammation is beneficial, only chronic inflammation is a problem. But treatments would reduce both.
> But treatments would reduce both.
Which is why the suggested solution is a lifestyle change to avoid the things that cause inflammation unnecessarily.
Re: Post-intensive care syndrome results from continuous inflammation
#6This topic is interesting to me for a few reasons... Cognitive impairment has long been associated with inflammation in older adults: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390758/ As well as the general population where illness is involved: https://psychcentral.com/news/2019/12/01/inflammation-linked... And it contributes to a variety of disorders (potentially almost all of them). The research here is pretty…
>We know that exercise levels and diet can lower or increase inflammation.
I think it is extremely important to distinguish the types of inflammation. Exercise creates acute inflammation (for example the breakdown of certain muscle tissue in response to being worked) and the inflammation causes the body to repair the muscle, typically the resulting muscle tissue is improved. Whereas dietary inflammation, or inflammation caused by certain foods, is generally chronic and has damaging effects on everything down to DNA in the cells and this damaged DNA can get copied into new cells.
>So we have this sort of rare magic bullet when it comes to health, cognition and aging. Lowering inflammation won't fix everything of course, but it will lower your risk of pretty much everything.
You said it perfectly following this statement, it is simple but unfortunately that does not make it easy.
Re: Post-intensive care syndrome results from continuous inflammation
#7Earlier quoted context omitted.
Big part of the problem is that inflammation is beneficial, only chronic inflammation is a problem. But treatments would reduce both.
> Big part of the problem is that inflammation is beneficial, only chronic inflammation is a problem. But what about anaphylaxis, hay fever, mild allergies etc. There are plenty of acute or non-chronic inflammatory conditions that are a problem.
We have acute antiinflammatories for these cases. And they have serious side effects, especially treatments for asthmatics.
Now interesting part here is the mechanism which is different from the one targeted by current drugs.
Re: Post-intensive care syndrome results from continuous inflammation
#8This makes me wonder what is happening during an extreme tooth ache. During those times when I have had a bad tooth it is like my mind is in slow motion and the ability to think is gone. I have had extreme pain and still been able to think clearly but with an inflamed tooth it’s a different experience.
Re: Post-intensive care syndrome results from continuous inflammation
#9Here's something I've never understood, although I suspect the question is an open one even among medical professionals:
Given that inflammation is an immune response, is it the inflammation itself that's bad, or the underlying condition? If we only treated inflammation symptoms without curing any of the underlying diseases, would there be a significant improvement in outcomes? Or would they be worse because you'd be interfering with the body's response?
Re: Post-intensive care syndrome results from continuous inflammation
#10Here's something I've never understood, although I suspect the question is an open one even among medical professionals: Given that inflammation is an immune response, is it the inflammation itself that's bad, or the underlying condition? If we only treated inflammation symptoms without curing any of the underlying diseases, would there be a significant improvement in outcomes? Or would they be worse because you'd be…
The article describes negative effects of inflammation which persists long after the underlying condition has been addressed, due to persistently elevated levels of the HMGB1 protein. It notes that "anti-HMGB1 treatment given several days after a serious illness can reduce cognitive decline in mice" and proposing that these results might some day be replicated in humans.