I predict that DoH will break many enterprise infrastructures that rely on custom DNS servers. Unwary sysadmins that update Firefox will be in a lot of trouble when they switch this on by default. We ourselves have a custom DNS setup with an only internally resolvable TLD as a security measure, so this change will break our infra for all Firefox users (thankfully we’re in the EU so we’re spared, for now). Good thing…
Additionally, if you've setup Firefox to be installed with Firefox for Enterprise, DoH is disabled by default and you've got nothing to worry about. DOH is able to be configured through GPO as well, allowing the use of a custom server.