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Clinical features of patients infected with 2019 novel coronavirus

thelancet.com

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Re: Clinical features of patients infected with 2019 novel coronavirus

#21

Post by sanxiyn »

rdtsc wrote: post #13

> 27 (66%) patients had direct exposure to Huanan seafood market (figure 1B https://www.thelancet.com/journals/lancet/article/PIIS0140-6... ). Market exposure was similar between the patients with ICU care (nine [69%]) and those with non-ICU care (18 [64%]). The symptom onset date of the first patient identified was Dec 1, 2019. None of his family members developed fever or any respiratory symptoms. No epidemiologica…

Chinese CDC collected environmental samples from the market and some of them tested positive. So it's a little more than "the market happened to be there", although your point about the first patient identified is valid.

http://www.xinhuanet.com/english/2020-01/27/c_138735677.htm

Re: Clinical features of patients infected with 2019 novel coronavirus

#22

Post by Pfhreak »

peter303 wrote: post #2

I am impressed how fast Chinese scientists developed a genetic test distinguish 2019-coronavirus from other kinds of pneumonia. I am old enough to remember biologists flailing around for 4 years to identify the HIV virus and two years more for slow (two week) test.

> I am old enough to remember biologists flailing around for 4 years to identify the HIV virus and two years more for slow (two week) test.

I suspect that part of this comes from the fact that people thought the disease was thought to target gay men. In fact, AIDS was originally called GRID -- Gay-Related Immune Deficiency. There was plenty of (truly awful) folks out there who felt that it was some sort of cosmic justice.

Re: Clinical features of patients infected with 2019 novel coronavirus

#23

Post by tony101 »

rdtsc wrote: post #13

> 27 (66%) patients had direct exposure to Huanan seafood market (figure 1B https://www.thelancet.com/journals/lancet/article/PIIS0140-6... ). Market exposure was similar between the patients with ICU care (nine [69%]) and those with non-ICU care (18 [64%]). The symptom onset date of the first patient identified was Dec 1, 2019. None of his family members developed fever or any respiratory symptoms. No epidemiologica…

"Novel Coronavirus May Not Have Originated in Wuhan Seafood Market":

https://www.sciencemag.org/news/2020/01/wuhan-seafood-market...

https://news.ycombinator.com/item?id=22157067

Re: Clinical features of patients infected with 2019 novel coronavirus

#24

Post by ImaCake »

angled wrote: post #11

My wife just pointed out what might be a spurious anecdote: no Caucasians died during the SARS epidemic in 2003, and none have died so far in response to this novel virus. Is there any data to back this up? (She was in Beijing during 2003, and saw SARS first hand)

There are a lot of explanations besides Caucasians being less suseptable. Because of monitoring by authorities one could imagine any Caucasians becoming infected are buisness people and wealthy-ish travellers. They would be healthy with few co-morbidities, are identified during initial symptoms (because of screening) and treated at world class facilities and monitored closely (quarantine and research).

Re: Clinical features of patients infected with 2019 novel coronavirus

#25

Post by s1artibartfast »

nnq wrote: post #9

It would be interesting to see less accurate statistics on the total CURRENT number of cases rather than this OLD NEWS. Cool for whoever published that, but we need more focus on speed of information dissemination, even prioritising it over accurracy, we're moving at pre-Internet pace here or someone is actively hindering the flow of info...

one might assume that those who need to know are in response rooms and have more current information. Im not sure that a minor delay to the general public makes any difference whatsoever on outcomes.

Re: Clinical features of patients infected with 2019 novel coronavirus

#26

Post by yegle »

angled wrote: post #11

My wife just pointed out what might be a spurious anecdote: no Caucasians died during the SARS epidemic in 2003, and none have died so far in response to this novel virus. Is there any data to back this up? (She was in Beijing during 2003, and saw SARS first hand)

This is just one of the populor rumors during the 2003 SARS epidemic, that because no Caucasian died from the virus, the whole epidemic is a well organized biological war against China.

Like the other comments has pointed out, Dr. Carlo Urbarni is a doctor who died from SARS. He's the one who warned the WHO about the new desease.

Re: Clinical features of patients infected with 2019 novel coronavirus

#27

Post by cliqueiq »

malandrew wrote: post #10
aaron695 wrote: post #7

We have 2700 confirmed cases, 80 dead. Some also in the West and we are still talking about these initial 41? Are we a pre or post internet civilisation? Honestly 4chan is doing better than this. Reading through their noise is better than the clean data coming out of the officials. For example they have people in pools of blood on the street with people in the bio suits China are using. Maybe it's obvious people will…

Where are you getting the 2700 and 80 numbers from? I couldn’t find a reliable up to date counter. Even the CDC only lists countries.

Those are legit numbers. Also 3/5 of the North American cases are new from yesterday.

Re: Clinical features of patients infected with 2019 novel coronavirus

#28

Post by azalemeth »

> "Suspected patients were isolated using airborne precautions in the designated hospital, Jin Yin-tan Hospital (Wuhan, China), and fit-tested N95 masks and airborne precautions for aerosol-generating procedures were taken.

> This study was approved by the National Health Commission of China and Ethics Commission of Jin Yin-tan Hospital (KY-2020-01.01).

> Written informed consent was waived by the Ethics Commission of the designated hospital for emerging infectious diseases."

In other words, data from every patient they had is reported in this paper, with or without their consent. That includes radiographic imaging, blood and respiratory specimens, including nasal and pharyngeal swabs, bronchoalveolar lavage fluid, sputum, and/or bronchial aspirates.

In a western country, one of the tenants of medical ethics is that, if you have capacity to consent, you can always refuse to give it. In my country, I would be personally liable for assault if I (invasively) collected these samples from patients _without_ their explicit consent.

It must be a terrifying situation to be in: sick, in respiratory distress, and isolated from your family and friends in a large hospital, surrounded only by presumably somewhat scared looking medical professionals wearing tightly fitting face masks. I just hope that patients were _verbally_ asked if they consented to the collection of bronchoscopy-obtained samples for research and hopefully their diagnosis and management: it is an unpleasant procedure that, like many things in medicine, carries a small but non-zero risk of serious injury or death.

Re: Clinical features of patients infected with 2019 novel coronavirus

#29

Post by angled »

yegle wrote: post #26
angled wrote: post #11

My wife just pointed out what might be a spurious anecdote: no Caucasians died during the SARS epidemic in 2003, and none have died so far in response to this novel virus. Is there any data to back this up? (She was in Beijing during 2003, and saw SARS first hand)

This is just one of the populor rumors during the 2003 SARS epidemic, that because no Caucasian died from the virus, the whole epidemic is a well organized biological war against China. Like the other comments has pointed out, Dr. Carlo Urbarni is a doctor who died from SARS. He's the one who warned the WHO about the new desease.

Thanks for clarifying!

Re: Clinical features of patients infected with 2019 novel coronavirus

#30

Post by crusty »

peter303 wrote: post #2

I am impressed how fast Chinese scientists developed a genetic test distinguish 2019-coronavirus from other kinds of pneumonia. I am old enough to remember biologists flailing around for 4 years to identify the HIV virus and two years more for slow (two week) test.

Not all fruits hang the same. Some hang low, some don't, and the tools we use to pick them change as we try.
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