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Acetaminophen and the War on Drugs (2009)

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61–65 of 65 posts

Re: Acetaminophen and the War on Drugs (2009)

#61

> Does anyone think cannabis is deadlier than Jim Beam? I think the vast majority of the population of America thinks that, which is why cannabis is much more highly regulated. What he should have said was, "cannabis is less deadly than Jim Bean", and provided the evidence to back it up.

Wait, they do? I can easily understand thinking it's more harmful, but deadlier? In what way would someone think it's deadly?

Re: Acetaminophen and the War on Drugs (2009)

#62

A bit like shooting someone who is attempting suicide. Prohibition v. 2 has proven to be just as disastrous as v. 1, when will there finally be enough political momentum behind ending it?

>...when will there finally be enough political momentum behind ending it?

I keep thinking next year... next year... but the reality is as people get older and have kids they start to view any sort of recreational drug as a threat to little Johnny. So that pot-head you knew in college? He's voting against every attempt to soften drug laws.

Re: Acetaminophen and the War on Drugs (2009)

#63

Sad to see an HN thread full of conspiracy theories and so little actual science. Believe it or not, acetaminophen is an effective analgesic, and combined with hydrocodone it provides synergistic pain relief without any increase in side effects over the use of either agent alone. Here's a peer-reviewed 1980 study from the UK showing just that: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1430165/ Private drug companie…

Warning: hydrocodone was well-tolerated by me, however I believe I incurred a small amount of ptosis (eyelid droop) as a result. If you take it, be on the lookout for the side effects.

Re: Acetaminophen and the War on Drugs (2009)

#64
post #55
post #48

Earlier quoted context omitted.

A study on post-partum pain from the 1980s? Try this one, a meta-analysis from 2000 on post-op pain: http://www.ncbi.nlm.nih.gov/pubmed/10796810 Acetaminophen is effective. Most professional guidelines on analgesia recommend the use of acetaminophen in addition to opioid analgesia. The useful and perhaps unique thing about acetaminophen among pain killers is that it is well tolerated. Almost everybody from little kid…

Upvoted, but what TFA is claiming is that codine w/o acetaminophen is roughly as affective as the combination, which isn't addressed in that analysis.

http://www.ncbi.nlm.nih.gov/pubmed/19588335 "AUTHORS' CONCLUSIONS: Single dose oxycodone is an effective analgesic in acute postoperative pain at doses over 5 mg; oxycodone is two to three times stronger than codeine. Efficacy increases when combined with paracetamol. Oxycodone 10 mg plus paracetamol 650 mg provides good analgesia to half of those treated, comparable to commonly used non-steroidal anti-inflammatory drugs, with the benefit of longer duration of action."

"http://www.ncbi.nlm.nih.gov/pubmed/20393966 AUTHORS' CONCLUSIONS: Single dose codeine 60 mg provides good analgesia to few individuals, and does not compare favourably with commonly used alternatives such as paracetamol, NSAIDs and their combinations with codeine, especially after dental surgery; the large difference between dental and other surgery was unexpected. Higher doses were not evaluated."

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