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Progress of anti-aging therapies by clinical trial stage

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Re: Progress of anti-aging therapies by clinical trial stage

#21

Post by DennisP »

LinuxBender wrote: post #17
chrisco255 wrote: post #10

Earlier quoted context omitted.

Not all of these are new drugs. NMN, for example, is a supplement that you can buy now. It's a bit expensive but the price is dropping as it becomes more popular. Others mentioned include HGH, which has been around for decades. Only problem there is that it's a controlled substance so getting a prescription for anti-aging purposes may be difficult.

I am not saying there isn't a use case for HGH, but you can increase your own natural HGH production through intermittent fasting, l-glutamine, and cycling up/down a few other molecules. I learned this by mistake, from trying to repair damage to my gut. The weird side effect was quite a bit of muscle development and I don't even work out. On top of that, I dampen mtorc1 with Berberine, Sulforaphane, Myrosinase, Trans…

I could really use that weird side effect. What other molecules did you cycle up/down?

Re: Progress of anti-aging therapies by clinical trial stage

#22

Post by ben_w »

bhouston wrote: post #6

Looks interesting, but how could I ever afford to buy ~12 designer drugs which I figure likely cost at least $1-2/day if they are effective? Cost per year is $4K- $8K? I'm guessing I'll wait 20 years until they are off patent?

That sounds cheap compared to the cost of old-age healthcare. For comparison, Alzheimer’s care homes cost ~£1000/week in the UK.

Re: Progress of anti-aging therapies by clinical trial stage

#23

Post by Japhy_Ryder »

lawrenceyan wrote: post #20

Proper sleep, a complete diet, minimizing stress (I'm personally biased towards meditation), intermittent fasting, and vigorous cardiovascular exercise complemented by strength training will by far have the most impact in maximizing your natural lifespan. You shouldn't look at doing anything else until you've at minimum mastered all of the listed items above. Nothing else will have as much outsized impact.

A vegan/plant-based diet and now we're talking! I like this list a lot!

Re: Progress of anti-aging therapies by clinical trial stage

#24

Post by The_rationalist »

ramraj07 wrote: post #16
jcadam wrote: post #5

They need to hurry up with this, I'm not getting any younger and I haven't saved enough for retirement :O

Many studies suggest it's easier to prevent ageing from the beginning rather than de-ageing old people :(

Where can I find more about this?

Re: Progress of anti-aging therapies by clinical trial stage

#25

Post by on_and_off »

Japhy_Ryder wrote: post #23
lawrenceyan wrote: post #20

Proper sleep, a complete diet, minimizing stress (I'm personally biased towards meditation), intermittent fasting, and vigorous cardiovascular exercise complemented by strength training will by far have the most impact in maximizing your natural lifespan. You shouldn't look at doing anything else until you've at minimum mastered all of the listed items above. Nothing else will have as much outsized impact.

A vegan/plant-based diet and now we're talking! I like this list a lot!

Agree that eating meat at every meal is a dumb idea but is there much difference between a plant based diet and a mediterranean one in this regard ?

Re: Progress of anti-aging therapies by clinical trial stage

#26

Post by joncrane »

chrisco255 wrote: post #10
bhouston wrote: post #6

Looks interesting, but how could I ever afford to buy ~12 designer drugs which I figure likely cost at least $1-2/day if they are effective? Cost per year is $4K- $8K? I'm guessing I'll wait 20 years until they are off patent?

Not all of these are new drugs. NMN, for example, is a supplement that you can buy now. It's a bit expensive but the price is dropping as it becomes more popular. Others mentioned include HGH, which has been around for decades. Only problem there is that it's a controlled substance so getting a prescription for anti-aging purposes may be difficult.

HGH is a wonder drug, but it's tricky. Not only for the expense factor, but like everything else, when you add exogenous hormones, your body stops producing them.

So if you supplement with HGH for years or even months, your body stops making it and the ability to produce more may take a very long time to come back. It may never come back.

Also, there are many types of tumors that have HGH receptors, and HGH has an even bigger impact on the tumor than it does on the rest of your body. So you're basically supercharging your cancer.

Re: Progress of anti-aging therapies by clinical trial stage

#27

Post by LinuxBender »

DennisP wrote: post #21
LinuxBender wrote: post #17

Earlier quoted context omitted.

I am not saying there isn't a use case for HGH, but you can increase your own natural HGH production through intermittent fasting, l-glutamine, and cycling up/down a few other molecules. I learned this by mistake, from trying to repair damage to my gut. The weird side effect was quite a bit of muscle development and I don't even work out. On top of that, I dampen mtorc1 with Berberine, Sulforaphane, Myrosinase, Trans…

I could really use that weird side effect. What other molecules did you cycle up/down?

I owe HN community a blog update on this process and I promise I will do that in the coming couple weeks. I've been a bit busy as of late. When I do, I will add it to my profile. It's not quite as simple as what to take, but also when to take, in what combinations and why. And it probably isn't the most scientific process, so I'm sure I will catch some flak for it.

Re: Progress of anti-aging therapies by clinical trial stage

#28

Post by dannykwells »

ska wrote: post #19
dannykwells wrote: post #2

Interesting but a bit confusing since most of these drugs are for other conditions, and are not seeking approval based on ability to slow/stop /reverse aging. Thus any approvals would require having a particular condition to get a prescription (or an unethical doctor), and this aren't immediately useful. Would be nice to be able to select only those drugs seeking broad spectrum approval based on specific aging biomar…

> Thus any approvals would require having a particular condition to get a prescription (or an unethical doctor), and this aren't immediately useful. That's not how any of this works (US specific to follow). FDA approval to market is a constraint on how the vendor markets a drug or device, not how a physician uses it. This is known as indications for use. So if I sell a drug approved for blood pressure, I can never sa…

Aware of what off label is, thank you, but I think you grossly misunderstand modern medicine if you think a doctor is going to prescribe a drug originally approved to treat cancer because you _hypothesize_ it might have some anti-aging properties.

That's the whole issue with this list: none of these trials are testing the anti-aging hypothesis - it's just mentioning particular pathways -like Wnt (a core development program and implicated in many, many aspects of human health) and saying that the drug would be anti-aging.

As for "unethical" - well, yes, the person would be unethical since they would likely being prescribing a drug for no reason, with no basis, based solely on misguided patient belief. This is more likely to endanger the patient than it is to help. Thus, unethical.

Re: Progress of anti-aging therapies by clinical trial stage

#29

Post by herodotus »

Quick summary of the meaning of Phases in medical trials:

Phase 0: exploration of effectiveness

Phase I: is the treatment safe?

Phase II: does the treatment work?

Phase III: is the treatment better than existing alternatives?

Phase IV: After approval, monitor the long term effects of the treatment.

Re: Progress of anti-aging therapies by clinical trial stage

#30

Post by ItsDeathball »

ben_w wrote: post #18
jcadam wrote: post #9

Earlier quoted context omitted.

If I'm healthy enough to keep working, retirement isn't really necessary. Also, given enough time, I ought to be able to amass a self-sustaining pile of wealth and then I can retire :)

If everyone does that, nobody is making the things you want to buy with that wealth pile. Not until we also get enough automation to also have UBI.

I don't think that's a problem in their scenario, since the situation is leveraging life extension to work past retirement age. Working until age 80 and living out retirement until 120 would mean a vastly expanded labor pool, unless you're assuming everyone stops having kids.
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