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Progress of anti-aging therapies by clinical trial stage

lifespan.io

11–20 of 151 posts

Re: Progress of anti-aging therapies by clinical trial stage

#11
post #6

Looks interesting, but how could I ever afford to buy ~12 designer drugs which I figure likely cost at least $1-2/day if they are effective? Cost per year is $4K- $8K? I'm guessing I'll wait 20 years until they are off patent?

This is my main concern too. That I'll fund the research and then not be able to afford the treatment.

something like "You gave $50 a month for 20 yrs to unlock the treatment, but now it costs $10000 and you cannot afford that? Too bad."

Re: Progress of anti-aging therapies by clinical trial stage

#12
post #6

Looks interesting, but how could I ever afford to buy ~12 designer drugs which I figure likely cost at least $1-2/day if they are effective? Cost per year is $4K- $8K? I'm guessing I'll wait 20 years until they are off patent?

Not all of these are new drugs. NMN, for example, is a supplement that you can buy now. It's a bit expensive but the price is dropping as it becomes more popular. Others mentioned include HGH, which has been around for decades. Only problem there is that it's a controlled substance so getting a prescription for anti-aging purposes may be difficult.

Hgh works wonders used it for about 3 months and got sixpack doing hardly any workout. Lost all excess fat. Got a better sleeping pattern. Its easy to get your hands on online. Problem is that its mad expensive even more so with a prescription as the stuff without you might get was stolen or a cheaper brand.

Re: Progress of anti-aging therapies by clinical trial stage

#13
post #6

Looks interesting, but how could I ever afford to buy ~12 designer drugs which I figure likely cost at least $1-2/day if they are effective? Cost per year is $4K- $8K? I'm guessing I'll wait 20 years until they are off patent?

Medical tourism.

Re: Progress of anti-aging therapies by clinical trial stage

#14

Interesting but a bit confusing since most of these drugs are for other conditions, and are not seeking approval based on ability to slow/stop /reverse aging. Thus any approvals would require having a particular condition to get a prescription (or an unethical doctor), and this aren't immediately useful. Would be nice to be able to select only those drugs seeking broad spectrum approval based on specific aging biomar…

Doctors are allowed to do off-label prescriptions and it's not considered unethical.

Re-use of existing drugs is one of the most parsimonious methods.

Re: Progress of anti-aging therapies by clinical trial stage

#15
post #4

Interesting but a bit confusing since most of these drugs are for other conditions, and are not seeking approval based on ability to slow/stop /reverse aging. Thus any approvals would require having a particular condition to get a prescription (or an unethical doctor), and this aren't immediately useful. Would be nice to be able to select only those drugs seeking broad spectrum approval based on specific aging biomar…

> any approvals would require having a particular condition to get a prescription (or an unethical doctor) Wrong on both counts. Let me introduce you to indian online pharmacies, where you can get mostly anything already. I get my eyedrops from less than the US deductible, delivered at my door. I have a prescription, but they didn't even check. Even better: some molecules are on any restricted list, and thus legal to…

Other than the condescending tone, this comment is probably worth keeping.

summary: there are extralegal, cheap, and convenient methods of collecting supplements/drugs that will be available to everyone with a credit card and the right risk tolerance, regardless of e.g. FDA approval.

Re: Progress of anti-aging therapies by clinical trial stage

#17
post #6

Looks interesting, but how could I ever afford to buy ~12 designer drugs which I figure likely cost at least $1-2/day if they are effective? Cost per year is $4K- $8K? I'm guessing I'll wait 20 years until they are off patent?

Not all of these are new drugs. NMN, for example, is a supplement that you can buy now. It's a bit expensive but the price is dropping as it becomes more popular. Others mentioned include HGH, which has been around for decades. Only problem there is that it's a controlled substance so getting a prescription for anti-aging purposes may be difficult.

I am not saying there isn't a use case for HGH, but you can increase your own natural HGH production through intermittent fasting, l-glutamine, and cycling up/down a few other molecules. I learned this by mistake, from trying to repair damage to my gut. The weird side effect was quite a bit of muscle development and I don't even work out. On top of that, I dampen mtorc1 with Berberine, Sulforaphane, Myrosinase, TransResveratrol, DIM+Quercertin and that should slow HGH production, but has the opposite effect and increases it.

And I second the NMN being expensive. I use about 800mg a day and it is by far the most expensive thing I take.

Re: Progress of anti-aging therapies by clinical trial stage

#18
post #9

Earlier quoted context omitted.

Yeah but if they extend your life won't you need even more for retirement?

If I'm healthy enough to keep working, retirement isn't really necessary. Also, given enough time, I ought to be able to amass a self-sustaining pile of wealth and then I can retire :)

If everyone does that, nobody is making the things you want to buy with that wealth pile. Not until we also get enough automation to also have UBI.

Re: Progress of anti-aging therapies by clinical trial stage

#19

Interesting but a bit confusing since most of these drugs are for other conditions, and are not seeking approval based on ability to slow/stop /reverse aging. Thus any approvals would require having a particular condition to get a prescription (or an unethical doctor), and this aren't immediately useful. Would be nice to be able to select only those drugs seeking broad spectrum approval based on specific aging biomar…

  > Thus any approvals would require having a particular condition to get a prescription (or an unethical doctor), and this aren't immediately useful.
That's not how any of this works (US specific to follow). FDA approval to market is a constraint on how the vendor markets a drug or device, not how a physician uses it. This is known as indications for use.

So if I sell a drug approved for blood pressure, I can never say it may improve longevity. If there are papers out there claiming good effects on longevity I as a vendor have to be very careful to never make a public claim about that.

However, if you as a physician have read the papers you can prescribe the drug for other uses based on your personal expertise. This is known as off-label (i.e. for a use not covered by the indications for use), and is very common. There are limits of course, but at the end of the day the limits are based on professional conduct/ malpractice - not the FDA. The FDA explicitly does not regulate the practice of medicine.

Note that this doesn't just apply to somewhat speculative uses. For example a significant amount of pediatric care is done off-label, because setting up the clinical trials for pediatric indications is a pain. This may only be a dose change, for example, but is very common.

Re: Progress of anti-aging therapies by clinical trial stage

#20
Proper sleep, a complete diet, minimizing stress (I'm personally biased towards meditation), intermittent fasting, and vigorous cardiovascular exercise complemented by strength training will by far have the most impact in maximizing your natural lifespan.

You shouldn't look at doing anything else until you've at minimum mastered all of the listed items above. Nothing else will have as much outsized impact.

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