An interesting thought experiment is to imagine an incredibly-detailed computer simulation of a brain, down to the level of individual cells and neurotransmitters. (While this is beyond our current capabilities, it is in principle possible.) Hook the brain up to some decent IO devices, and you’d have an extremely human-like “AI”. (I’m glossing over some tricky details like, do you start with a fetus/baby brain and le…
So no, I don't think it's possible to create a simulated brain that behaves similarly as a human, as the biological medium is in a constant state of dissolution, repair, evolution, and adaptation. This is how we learn, get stressed, get tired, get certain emotions...it's a whole new layer of programming you'd need to perfect beyond just replicating a brain at one moment in time.
A brain in silico would be apples:oranges different than a biological brain.