How would you express the central point? Or is it the central point that you disagree with, or feel is "toxic"? (I dislike that word, because it's one of those words that has a tendency to shut down rational discussion).
On a certain level, I probably agree with you. The word 'loser' dehumanizes people by focusing on their lack of achievements that society cares about, and achievements or agency in their own life.
How do they feel about this state of things? Probably not so good. Why did this happen, and what can they do about it? Well, maybe they're stuck in a shitty situation due to a confluence of psychological or even medical factors that's largely outside of their control. Maybe they're deserving of a break, some sympathy or a helping hand.
But if a person (who might or might not be in this situation) happens to behave destructively towards others, it's possible to discuss that while still acknowledging the points above.
Maybe 'loser' and 'less than a man' is an insensitive way to express it, which is why I was asking how you would express the central point. I think that "Ignore the haters, they're just fanboys with the sign flipped and not important" is sound advice to someone who tries to keep their sanity while attempting to do something good under a massive amount of scrutiny and criticism (some founded, most unfounded).
I don't think we have to go so far to see examples of famous people that would have been much less stressed, had less problems and kept their focus if they'd been able to follow this advice in times of extreme stress. A couple of Elon Musk's famed Twitter episodes come to mind, if you're looking for examples.
Even though famous people are in a position of privilege, they're still humans and have to endure the same emotional reactions as the rest of us. Usually amplified, since they get such a massive amount of attention. I think it's valuable to give them some coping tips.