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Scientists identify pathways that extend nematode worm lifespan fivefold

phys.org

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Re: Scientists identify pathways that extend nematode worm lifespan fivefold

#81
post #56

Earlier quoted context omitted.

Great read. The combination of metformin, revaratrol and NMN is quite something. Add fasting and an intense workouts and it’s amazing how much you can impact your wellness. I recently unretired from the over 40 hockey league i’ve played in the past 8 years and rejoined the top A league playing against 20 year olds... anecdotal sure... but then again so are those sets of 30-40 pull-ups I do in my workout multiple time…

> I’m currently 52 and look mid 30s and have taken supplements for nearly 10 years to affect aging. Might want some anonymous feedback on how old you really look before you use this tagline in the wild. ;) It's always a bit awkward when someone tells you how many 15+ years younger they [think they] look and you're stuck between "should I tell them?" and "smile and nod." I always presume they keep getting older but fo…

My wife is 32 and all her friends and relatives have guessed my age at 36.

Re: Scientists identify pathways that extend nematode worm lifespan fivefold

#82
post #80
post #78

Earlier quoted context omitted.

1 gram of NMN, metformin and resveratrol. Beyond that I take other things including carbon 60. Those are the most exotic items; the rest are your usual items such as fish-oil, krill oil, multi-vitiman most of which I tuned from my Inside-Tracker.com blood results. I also have the right genetics; aka longevity gene(s), Ashkenazi Jew markers, etc and my farther is in his upper 80's; his mother lived to 98. I don't want…

Does your father looks a lot younger too? My father is in his mid 50s and he looks 40. I am in my mid 30s and I look younger too. This is genetics obviously. I am also doing fasting 16/8 and eat less than most people. It's possible that those supplements have 0 effects and it's all just genetics.

Not really but he smoked for 40 years before quitting around age 55.

Or it’s possible the preliminary results are correct.

Re: Scientists identify pathways that extend nematode worm lifespan fivefold

#83
post #78

Earlier quoted context omitted.

Which supplements are you taking? NMN? Niagen?

1 gram of NMN, metformin and resveratrol. Beyond that I take other things including carbon 60. Those are the most exotic items; the rest are your usual items such as fish-oil, krill oil, multi-vitiman most of which I tuned from my Inside-Tracker.com blood results. I also have the right genetics; aka longevity gene(s), Ashkenazi Jew markers, etc and my farther is in his upper 80's; his mother lived to 98. I don't want…

I do all of those things, but I am finding the NMN to be quite costly. I take almost the same amount as Dr. Sinclair, which means going through a bottle of pills every three to five days. I really hope someone makes a less expensive version soon. I do feel the difference and can probably attribute it to higher ATP production. I have no idea if it's helping my cardio vascular system.

Re: Scientists identify pathways that extend nematode worm lifespan fivefold

#84
post #78

Earlier quoted context omitted.

Which supplements are you taking? NMN? Niagen?

1 gram of NMN, metformin and resveratrol. Beyond that I take other things including carbon 60. Those are the most exotic items; the rest are your usual items such as fish-oil, krill oil, multi-vitiman most of which I tuned from my Inside-Tracker.com blood results. I also have the right genetics; aka longevity gene(s), Ashkenazi Jew markers, etc and my farther is in his upper 80's; his mother lived to 98. I don't want…

Don't you need a prescription for those supplements (or at least, metformin)?

Re: Scientists identify pathways that extend nematode worm lifespan fivefold

#85
post #47

Earlier quoted context omitted.

If you have a way to brush aside death, do share with us. So far as I can tell, nothing about the attempts have been cavalier. Fortunes have been squandered, tears wept over the fresh graves of the beloved, lives were focused in an all-consuming passion, and so forth. The subject has already been rendered not cavalier by the agonies of our past. We haven't a "skip death" button to press. Chesterson's fence, which you…

> Evolution is not wise, evolution is not careful, evolution did not plan or reason for that fence. Evolution also gave us susceptibility to diseases, revolting parasites, defects of birth, and an often tragic fragility. Shall we preserve those as well? After all, they must be there for a reason. Copy. Mutate. Select. Simple algorithm, remarkable results. Incredibly robust to failure. I think you do yourself a disser…

You genes don't care about you, the individual, one tiny bit. What matters is if a set of genes propagates or not.

You might as well return the favor.

Re: Scientists identify pathways that extend nematode worm lifespan fivefold

#86
post #26

Earlier quoted context omitted.

You’re kidding, right? These conversations frequently tend to devolve into a long discussion about the negative on hacker news. In fact, 3 years ago I wrote that this story should be banned from HN: https://h4labs.wordpress.com/2017/03/28/stories-that-should-... “Death gives life meaning” “It’ll only be for rich people” “The money should be spent on something better.” If we spent as much time trying to solve the prob…

So you wrote your opinion on some blog... doesn't make it any more relevant than any other opinion, here, there, anywhere. This is a public forum. Death is an interesting topic, plenty of people are scared shitless of it, regardless of their beliefs. Many wish that they would be that special spark that will live almost forever, ideally young, but god forbids that everybody else with them gets the same chance (simple…

What's wrong with all those higher priority items exactly?

Re: Scientists identify pathways that extend nematode worm lifespan fivefold

#87
post #78

Earlier quoted context omitted.

1 gram of NMN, metformin and resveratrol. Beyond that I take other things including carbon 60. Those are the most exotic items; the rest are your usual items such as fish-oil, krill oil, multi-vitiman most of which I tuned from my Inside-Tracker.com blood results. I also have the right genetics; aka longevity gene(s), Ashkenazi Jew markers, etc and my farther is in his upper 80's; his mother lived to 98. I don't want…

Don't you need a prescription for those supplements (or at least, metformin)?

You can substitute it with over-the-counter Berberine: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839379/

Re: Scientists identify pathways that extend nematode worm lifespan fivefold

#88
post #81

Earlier quoted context omitted.

> I’m currently 52 and look mid 30s and have taken supplements for nearly 10 years to affect aging. Might want some anonymous feedback on how old you really look before you use this tagline in the wild. ;) It's always a bit awkward when someone tells you how many 15+ years younger they [think they] look and you're stuck between "should I tell them?" and "smile and nod." I always presume they keep getting older but fo…

My wife is 32 and all her friends and relatives have guessed my age at 36.

Good for you! But hasn't this always been the case i.e. looking / 25 when you were 36?

Re: Scientists identify pathways that extend nematode worm lifespan fivefold

#89
post #78

Earlier quoted context omitted.

1 gram of NMN, metformin and resveratrol. Beyond that I take other things including carbon 60. Those are the most exotic items; the rest are your usual items such as fish-oil, krill oil, multi-vitiman most of which I tuned from my Inside-Tracker.com blood results. I also have the right genetics; aka longevity gene(s), Ashkenazi Jew markers, etc and my farther is in his upper 80's; his mother lived to 98. I don't want…

I do all of those things, but I am finding the NMN to be quite costly. I take almost the same amount as Dr. Sinclair, which means going through a bottle of pills every three to five days. I really hope someone makes a less expensive version soon. I do feel the difference and can probably attribute it to higher ATP production. I have no idea if it's helping my cardio vascular system.

You'll notice if you stop; that's what happened to me when my NMN went on back-order and stopped for 8 days.

Like metformin NMN doesn't produce any significant immediate noticeable effect like Alpha-GPC for example; it's more like working out - overtime the long-term effects are significant. At least that's the hope.

I buy my NMN in a month supply at a time (150 a month).

Re: Scientists identify pathways that extend nematode worm lifespan fivefold

#90
post #87

Earlier quoted context omitted.

Don't you need a prescription for those supplements (or at least, metformin)?

You can substitute it with over-the-counter Berberine: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839379/

Or take both like I do. Berberine is not as effective as metformin, but every bit helps when lowering blood sugar levels go.
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