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Scientists identify pathways that extend nematode worm lifespan fivefold

phys.org

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Re: Scientists identify pathways that extend nematode worm lifespan fivefold

#51
post #12

All longevity accomplishments work better with smaller animals. The increase of the lifespan decreases with the size of the animal. If the increase of healthy human lifespan is something like 5% that would be a huge accomplishment and nothing to sneer at.

Many orthopaedists in my circle tell me that with all the office work we probably should be glad if we die with 60. These approaches focus on cardiovascular system and general cell renewal, but I guess there are just a few more steps until immortality.

"we probably should be glad if we die with 60." - what are you saying here?

Re: Scientists identify pathways that extend nematode worm lifespan fivefold

#52

I was at a holiday party and some guy was telling me all about the exciting life extension breakthroughs he was reading about in mass media. I tried to explain that, while exciting, what works in mice models is highly unlikely to directly scale into humans and that making progress against aging is very probably a "wicked" problem. I pointed out how many headlines we saw in the 80s about a "cure" for cancer being just…

Sadly this thinking is slowing down real scientific progress in the very real race to cure aging.

Re: Scientists identify pathways that extend nematode worm lifespan fivefold

#53
post #47

Earlier quoted context omitted.

If you have a way to brush aside death, do share with us. So far as I can tell, nothing about the attempts have been cavalier. Fortunes have been squandered, tears wept over the fresh graves of the beloved, lives were focused in an all-consuming passion, and so forth. The subject has already been rendered not cavalier by the agonies of our past. We haven't a "skip death" button to press. Chesterson's fence, which you…

> Evolution is not wise, evolution is not careful, evolution did not plan or reason for that fence. Evolution also gave us susceptibility to diseases, revolting parasites, defects of birth, and an often tragic fragility. Shall we preserve those as well? After all, they must be there for a reason. Copy. Mutate. Select. Simple algorithm, remarkable results. Incredibly robust to failure. I think you do yourself a disser…

This process that gave rise to me also gave me a painful, lifetime disability ... in its wisdom.

Re: Scientists identify pathways that extend nematode worm lifespan fivefold

#54
post #27

Earlier quoted context omitted.

That was my question -- what is IIS and TOR? What does it mean to modify them?

Have a read of these two regarding TOR - Target Of Rapamycin: https://en.wikipedia.org/wiki/MTOR https://en.wikipedia.org/wiki/Sirolimus - particularly the research section

Thank you!

Re: Scientists identify pathways that extend nematode worm lifespan fivefold

#55
post #8

1. In c elegans 2. "Biological scientists" vs "Biologists". What's the distinction?

There is a lot of cooperation in biology. People from diverse backgrounds – physics, chemistry, engineering, computer science, mathematics, medicine – work in the same research group. They are scientists who research biology, but they are not biologists as in they don't have a degree in biology.

thanks for clarification!

Re: Scientists identify pathways that extend nematode worm lifespan fivefold

#56
post #48

I was at a holiday party and some guy was telling me all about the exciting life extension breakthroughs he was reading about in mass media. I tried to explain that, while exciting, what works in mice models is highly unlikely to directly scale into humans and that making progress against aging is very probably a "wicked" problem. I pointed out how many headlines we saw in the 80s about a "cure" for cancer being just…

There's some really exciting research going on around ageing (and cancer as they are quite related) recently. I'm someone very far outside the field, but as far as I can tell we're starting to understand cancer (and ageing) on a much deeper molecular machinery kind of level. Combined with epigenetics it really does look quite doable to extend lifespans of humans as well. I mean there have been techniques known for mi…

Great read. The combination of metformin, revaratrol and NMN is quite something. Add fasting and an intense workouts and it’s amazing how much you can impact your wellness.

I recently unretired from the over 40 hockey league i’ve played in the past 8 years and rejoined the top A league playing against 20 year olds... anecdotal sure... but then again so are those sets of 30-40 pull-ups I do in my workout multiple times a week... incidentally in my 30s I could only do 15 pull-ups... been steadily increasing the last few years much to the surprise of my 20 year old teammates I workout with. I’m currently 52 and look mid 30s and have taken supplements for nearly 10 years to affect aging.

Re: Scientists identify pathways that extend nematode worm lifespan fivefold

#57

I was at a holiday party and some guy was telling me all about the exciting life extension breakthroughs he was reading about in mass media. I tried to explain that, while exciting, what works in mice models is highly unlikely to directly scale into humans and that making progress against aging is very probably a "wicked" problem. I pointed out how many headlines we saw in the 80s about a "cure" for cancer being just…

When you see an article on HN about how someone took some code, profiled it, and increased its speed by 10 times, I think it's tempting to credit virtue to the person who sped the code up. But I think you also have to remember that the only reason you could speed up the code by 10 times in the first place is that the original code left that much on the table. It isn't just that there is a person who was skilled enough to speed the code up, it is that somebody else left the opportunity behind in the first place.

For similar reasons, I find it quite likely to be engineering-meaningless [1] when someone takes a life form that lives for a 2-3 weeks and extends that by a factor of 5. We humans have the "live for fifteen weeks" problem solved. Optimization being what it is, it is very likely that whatever that improvement is already effectively exists in us. (Possibly not directly, possibly through some other mechanism that doesn't completely match, but it's probably done.) It is, unfortunately, much less impressive to "optimize" an organism that has left that much on the table.

Improve an elephant's lifespan by 50% with an intervention when they're already fully-grown and I'll really take notice. Unfortunately, there's all kinds of reasons why that's hard....

[1]: Contrast with meaningful to science. There's nothing wrong with studying this sort of thing as steps to both eventually treating aging, and just plain scientific understanding of the world, in the mean time. But something can be scientifically useful, and even perhaps someday eventually be useful to engineering through its contribution to a dozen other discoveries, while being "engineering-useless" today. Remember the context we're speaking in is in being excited about all the longevity news in the media and to hope that maybe it'll be ready by the time we personally need it.

Re: Scientists identify pathways that extend nematode worm lifespan fivefold

#58
post #13

Whats interesting is that according to the Bible humans lived from several hundred years to ~1000 years. Now this article is saying "The increase in lifespan would be the equivalent of a human living for 400 or 500 years, according to one of the scientists." Mind blown! Ages of the Patriarchs from Adam to Noah: 1. Adam 930years Genesis 5:4; 2. Seth 912years Genesis 5:8; 3. Enosh 905years Genesis 5:11; 4. Cainan 910ye…

we're trying to have an intelligent discussion here and you bring religious garbage

Re: Scientists identify pathways that extend nematode worm lifespan fivefold

#59
post #22

Surprise, a counter-argument on hacker news! :) Why does it seem no one worries about what we might break in humanity by disrupting the evolved pattern of death. It's a network characteristic selected for in living system, and very few creatures have survived into our epoch without developing the capacity to die. It's literally an evolved feature of our lifecycle and our existence within this web, and it terrifies me…

CGP gray's videos on YouTube are maybe the most concise and fun to watch materials I've seen on the subject.

https://www.youtube.com/watch?v=C25qzDhGLx8

https://www.youtube.com/watch?v=cZYNADOHhVY

And you'll be surprised how many people _are_ indeed thinking about all of the outcomes. Have in mind though that as with any technology it is not good or bad, and if it is possible someone will do it sooner or later.

It makes no sense to not do it as your adversaries will, and then they'll dictate how it is used, probably not to your liking. If you develop it first you can talk and deliberate at your leisure and find solutions that look much better to you and yours.

Re: Scientists identify pathways that extend nematode worm lifespan fivefold

#60
post #56
post #48

Earlier quoted context omitted.

There's some really exciting research going on around ageing (and cancer as they are quite related) recently. I'm someone very far outside the field, but as far as I can tell we're starting to understand cancer (and ageing) on a much deeper molecular machinery kind of level. Combined with epigenetics it really does look quite doable to extend lifespans of humans as well. I mean there have been techniques known for mi…

Great read. The combination of metformin, revaratrol and NMN is quite something. Add fasting and an intense workouts and it’s amazing how much you can impact your wellness. I recently unretired from the over 40 hockey league i’ve played in the past 8 years and rejoined the top A league playing against 20 year olds... anecdotal sure... but then again so are those sets of 30-40 pull-ups I do in my workout multiple time…

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