Live data from Hacker News

Drugs that tamp down inflammation in the brain could slow cognitive decline

news.berkeley.edu

11–20 of 80 posts

Re: Drugs that tamp down inflammation in the brain could slow cognitive decline

#11

Aside from the drugs mentioned, read "Why We Sleep" by Matthew Walker and all the natural hormonal drugs that happen when one consistently sleeps.

Not that fast. Unfortunately, "Why We Sleep" appears to be rather controversial.

[1] https://guzey.com/books/why-we-sleep/

[2] https://www.wired.com/story/stop-obsessing-over-sleepyour-br...

Re: Drugs that tamp down inflammation in the brain could slow cognitive decline

#12
post #2

Inflammation in all parts of the body seem to be problematic and the source of all kinds of disease and other sorts of deficiencies. What sorts of studies and preventative treatments are leading this field?

From all my readings, some natural preventative strategies seem to be: not eating sugar or long chain complex carbohydrates and sleeping consistently a full night of sleep (removing alcohol or caffeine cited multiple times seems to help).

Sleep (and related, circadian health) are some super interesting topics of emerging research. For those that like books, there are two recent ones written by researchers in the field. Matthew Walker's Why We Sleep, and Satchin Panda's Circadian Code that are pretty breezy reads. (there are YouTube interviews and TED talks as well):

For those that prefer more succinct reviews and want to spelunk citations, these are a couple good starting points:

Potter, Gregory D. M., Debra J. Skene, Josephine Arendt, Janet E. Cade, Peter J. Grant, and Laura J. Hardie. “Circadian Rhythm and Sleep Disruption: Causes, Metabolic Consequences, and Countermeasures.” Endocrine Reviews 37, no. 6 (December 2016): 584–608. https://doi.org/10.1210/er.2016-1083.

Manoogian, Emily NC, and Satchidananda Panda. “Circadian Rhythms, Time-Restricted Feeding, and Healthy Aging.” Ageing Research Reviews 39 (October 2017): 59–67. https://doi.org/10.1016/j.arr.2016.12.006.

Re: Drugs that tamp down inflammation in the brain could slow cognitive decline

#13
post #11

Aside from the drugs mentioned, read "Why We Sleep" by Matthew Walker and all the natural hormonal drugs that happen when one consistently sleeps.

Not that fast. Unfortunately, "Why We Sleep" appears to be rather controversial. [1] https://guzey.com/books/why-we-sleep/ [2] https://www.wired.com/story/stop-obsessing-over-sleepyour-br...

Maybe, but we do sleep for roughly 1/3rd of our life. Something might be in there.

Re: Drugs that tamp down inflammation in the brain could slow cognitive decline

#14
post #5

From the perspective of a non-biologist reader only seeing popular articles, the past ten years have been completely bewildering. Nutrition has seemingly been boiled down to a couple of magic totems that are always simplistically either good or bad. Antioxidants are good. Inflammation is bad. Telomeres are good. Carbs are bad. All the "bad" things get associated with each other and anti-associated with the good thing…

>>Biology isn't supposed to be this simple. If inflammation were always bad, our bodies wouldn't have evolved to do it.

People think that they can "hack" the body and live to 4000 years. What if biology is pretty simple: some things are good, some bad, but even if you do all the "good things," unexpected things will happen and either way you'll die one day. Find a mate to pass your genes, raise your kids and start saying your goodbye! The fact that we now live some 30-40 years after our kids are grown, is a bonus, but that doesn't mean that it is unlimited.

Re: Drugs that tamp down inflammation in the brain could slow cognitive decline

#15
post #5

From the perspective of a non-biologist reader only seeing popular articles, the past ten years have been completely bewildering. Nutrition has seemingly been boiled down to a couple of magic totems that are always simplistically either good or bad. Antioxidants are good. Inflammation is bad. Telomeres are good. Carbs are bad. All the "bad" things get associated with each other and anti-associated with the good thing…

>> Biology isn't supposed to be this simple. If inflammation were always bad, our bodies wouldn't have evolved to do it. People think that they can "hack" the body and live to 4000 years. What if biology is pretty simple: some things are good, some bad, but even if you do all the "good things," unexpected things will happen and either way you'll die one day. Find a mate to pass your genes, raise your kids and start s…

> Find a mate to pass your genes, raise your kids

What about those who are not fortunate enough to have kids or pass on genes like gays?

Re: Drugs that tamp down inflammation in the brain could slow cognitive decline

#16
post #15

Earlier quoted context omitted.

>> Biology isn't supposed to be this simple. If inflammation were always bad, our bodies wouldn't have evolved to do it. People think that they can "hack" the body and live to 4000 years. What if biology is pretty simple: some things are good, some bad, but even if you do all the "good things," unexpected things will happen and either way you'll die one day. Find a mate to pass your genes, raise your kids and start s…

> Find a mate to pass your genes, raise your kids What about those who are not fortunate enough to have kids or pass on genes like gays?

adopt, raise, long life. Or just live. My post wasn't meant to include everyone or exclude a specific group. (they are some who can't have kids for example, or refuse to...etc.etc. But in general we want to pass down our genes)

Re: Drugs that tamp down inflammation in the brain could slow cognitive decline

#17
post #5

From the perspective of a non-biologist reader only seeing popular articles, the past ten years have been completely bewildering. Nutrition has seemingly been boiled down to a couple of magic totems that are always simplistically either good or bad. Antioxidants are good. Inflammation is bad. Telomeres are good. Carbs are bad. All the "bad" things get associated with each other and anti-associated with the good thing…

The good versus bad narrative is also determined by the source/reader's orientation:

Western medicine is corrupt and bad; natural solutions are wholesome and good.

Natural medicine is anti-science and bad; western medicine = science and good.

Each side is engaged in a turf war with the other. IMO, there are pros and cons to each, but the dogmatism clouds adherents to the potential of the enemy's understanding and solutions. That potential seems to be inflated and premature in the case of natural medicine, and sometimes deceived via bias by money-interests in the case of western medicine. Pursuing natural treatments to the exclusion of western treatments can prevent a person from using something that has proven effect; pursuing western treatments to the exclusion of natural treatments can be signing on to destructive side effects.

Re: Drugs that tamp down inflammation in the brain could slow cognitive decline

#19
post #15

Earlier quoted context omitted.

> Find a mate to pass your genes, raise your kids What about those who are not fortunate enough to have kids or pass on genes like gays?

adopt, raise, long life. Or just live. My post wasn't meant to include everyone or exclude a specific group. (they are some who can't have kids for example, or refuse to...etc.etc. But in general we want to pass down our genes)

This is exactly the problem. In general the society expects us to pass on our genes by default. And those unfortunate feel that if they can’t pass on their genes there is something wrong with them.

Re: Drugs that tamp down inflammation in the brain could slow cognitive decline

#20
post #11

Aside from the drugs mentioned, read "Why We Sleep" by Matthew Walker and all the natural hormonal drugs that happen when one consistently sleeps.

Not that fast. Unfortunately, "Why We Sleep" appears to be rather controversial. [1] https://guzey.com/books/why-we-sleep/ [2] https://www.wired.com/story/stop-obsessing-over-sleepyour-br...

"I study sleep. While some of walker's claims may be hyperbolic, I think they are within reason and justified by the important message he is trying to convey. Too many people have begun to forego sleep in their health choices, and he has helped raise awareness of sleep's role in our health.

Many of these criticisms are quite unfair or misunderstanding the science."

https://www.reddit.com/r/slatestarcodex/comments/dwtr0m/matt...

Post reply on HN