I'm surprised not to find any mention to the diseases brought by the conquistadores. Quick glance at literature seems to indicate a consensus on the outsized importance of diseases in demographic changes in the Americas. Just over 100 years before the arrival of Cortés, Europe was going through similar epidemic disaster with the Black Plague also brought through intercontinental contact between people's. Then, the pl…
The diseases do not appear to have been a particularly major factor in the defeat of the Aztec Triple Alliance, mostly occurring after the polity had already collapsed.
“As the Indians did not know the remedy of the disease, they died in heaps, like bedbugs. In many places it happened that everyone in a house died, and as it was impossible to bury the great number of dead, they pulled down the houses over them, so that their homes became their tombs.”
https://theconversation.com/how-smallpox-devastated-the-azte...