New universe of miniproteins is upending cell biology and genetics
1–10 of 121 posts
Re: New universe of miniproteins is upending cell biology and genetics
#2Imagine trying to understand biology like we try to understand what we code day to day. I would need a brain at least 100x as large and efficient.
Re: New universe of miniproteins is upending cell biology and genetics
#3Imagine trying to understand biology like we try to understand what we code day to day. I would need a brain at least 100x as large and efficient.
[deleted]
Re: New universe of miniproteins is upending cell biology and genetics
#4Imagine trying to understand biology like we try to understand what we code day to day. I would need a brain at least 100x as large and efficient.
There are early efforts under way to do just that: https://www.youtube.com/watch?v=RjD1aLm4Thg
Re: New universe of miniproteins is upending cell biology and genetics
#5*
'Small proteins also promise to revise the current understanding of the genome. Many appear to be encoded in stretches of DNA—and RNA—that were not thought to help build proteins of any sort. Some researchers speculate that the short stretches of DNA could be newborn genes, on their way to evolving into larger genes that make full-size proteins. Thanks in part to small proteins, "We need to rethink what genes are," says microbiologist and molecular biologist Gisela Storz of the National Institute of Child Health and Human Development in Bethesda, Maryland.'
Wow. Amazing how incredible biology and proteins are and their still-barely-understood mechanisms. For anyone who hasn't already seen it, I highly recommend The Inner Life of a Cell [0]
Re: New universe of miniproteins is upending cell biology and genetics
#6Oof. Every year I regret not sticking with genomics/ biology. Its changed so quickly that even what I learned at the beginning of this decade seems very outdated.
Re: New universe of miniproteins is upending cell biology and genetics
#7* 'Small proteins also promise to revise the current understanding of the genome. Many appear to be encoded in stretches of DNA—and RNA—that were not thought to help build proteins of any sort. Some researchers speculate that the short stretches of DNA could be newborn genes, on their way to evolving into larger genes that make full-size proteins. Thanks in part to small proteins, "We need to rethink what genes are,"…
This is why you should be very skeptical of anyone who claims transparency between genetics and complex phenotypes.
Re: New universe of miniproteins is upending cell biology and genetics
#8Disclaimer: These are novel chemicals and most sources you can find them from are questionable at best. Don't even consider using these without deeply researching the risks from the specific peptide, the quality control of the supplier, as well as the inherent risks of injecting substances of questionable purity.
---
BPC-157 is a really interesting peptide
https://en.wikipedia.org/wiki/BPC-157
"It has been tested in animal trials for cytoprotective and wound healing activities. BPC-157 can contribute to wound healing due to muscle and tendon rejuvenating properties through accelerating the rate of angiogenic repair."
It is cheap and readily available (on Amazon even!), when injected it appears to greatly accelerate recovery from injuries - it's been called the "Wolverine drug" (as in the x-men character with superhuman healing powers). It requires injection, so its use is most common in bodybuilders who are aren't as averse to injecting questionable substances.
Many stories from people claiming it successfully repaired years-old tendon injuries and such. Some claim that oral administration can help with gut issues as well.
Some select testimonials: Rotator cuff injury recovery - https://www.reddit.com/r/Peptides/comments/8iqbv9/bpc_157_is...
Bicep tendon rupture recovery - https://www.reddit.com/r/powerlifting/comments/5ewi2j/bpc157...
Non-surgical repair of rat achilles tendon - https://www.ncbi.nlm.nih.gov/pubmed/16583442
---
Melanotan is another interesting one - it's an injectable peptide that increases melanin in the skin. From the image journals I've seen reporting progress over time, it definitely is highly effective - one individual used for several months and went from a pasty caucasian to looking Indian or almost Black. He decided to discontinue his trial when his friends started making 'blackface' comments.
---
I think it's a really exciting area of research, and I'm glad the people willing to take these risks post about it so readily on the /r/Peptides subreddit. Not for me, but I'm glad they're publishing the results of their n=1 studies!
Re: New universe of miniproteins is upending cell biology and genetics
#9Disclaimer: These are novel chemicals and most sources you can find them from are questionable at best. Don't even consider using these without deeply researching the risks from the specific peptide, the quality control of the supplier, as well as the inherent risks of injecting substances of questionable purity. --- BPC-157 is a really interesting peptide https://en.wikipedia.org/wiki/BPC-157 "It has been tested in…
> one individual used for several months and went from a pasty caucasian to looking Indian or almost Black
Crazy to think there's people out there doing this not for a high, maybe not even for science, but for...?
Re: New universe of miniproteins is upending cell biology and genetics
#10Disclaimer: These are novel chemicals and most sources you can find them from are questionable at best. Don't even consider using these without deeply researching the risks from the specific peptide, the quality control of the supplier, as well as the inherent risks of injecting substances of questionable purity. --- BPC-157 is a really interesting peptide https://en.wikipedia.org/wiki/BPC-157 "It has been tested in…
> one individual used for several months and went from a pasty caucasian to looking Indian or almost Black Crazy to think there's people out there doing this not for a high, maybe not even for science, but for...?
[deleted]