There's very few places where there is an overlap of "jobs that pay $100k" and "homes that can be afforded at $100k salary".
Remote work is becoming more "real" by the day, so it's certainly possible in the age of the internet to work remotely in a low cost location while making a salary competitive with a higher cost of living city like SF/NY/LA.
Plenty of machinists, auto mechanics, health care professionals and welders aren't gonna have much luck working from home.