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Slow walking at 45 'a sign of faster ageing'

bbc.co.uk

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Re: Slow walking at 45 'a sign of faster ageing'

#11

Post by ollysb »

NotSammyHagar wrote: post #8
Scoundreller wrote: post #2

> A number of treatments, from low-calorie diets to taking the drug metformin, are currently being investigated. Everything I read about metformin is exciting: cheap, simple structure, causes weight loss, reduced all-cause mortality in diabetics (ie: they studied it long enough to make sure it works, not just to ensure it reduces blood sugar), reduces blood sugar without hypoglycemia and might prevent cancer.

Yes, I want to find a doc to prescribe me this and also understands the negatives. Why aren't there more docs doing this kind of stuff? Maybe bc it is not so simple?

The side effects can be pretty nasty. I took it for 6 months and the stomach pain and diarrhoea never went away. Berberine however acts on the same pathways as metformin and doesn’t cause the side effects. As a bonus you don’t need a prescription to take it.

Re: Slow walking at 45 'a sign of faster ageing'

#12

Post by throwaway5752 »

NotSammyHagar wrote: post #8
Scoundreller wrote: post #2

> A number of treatments, from low-calorie diets to taking the drug metformin, are currently being investigated. Everything I read about metformin is exciting: cheap, simple structure, causes weight loss, reduced all-cause mortality in diabetics (ie: they studied it long enough to make sure it works, not just to ensure it reduces blood sugar), reduces blood sugar without hypoglycemia and might prevent cancer.

Yes, I want to find a doc to prescribe me this and also understands the negatives. Why aren't there more docs doing this kind of stuff? Maybe bc it is not so simple?

Black boxed. Lactic acidosis.

Re: Slow walking at 45 'a sign of faster ageing'

#13

Post by toast0 »

Scoundreller wrote: post #10
NotSammyHagar wrote: post #8

Earlier quoted context omitted.

Yes, I want to find a doc to prescribe me this and also understands the negatives. Why aren't there more docs doing this kind of stuff? Maybe bc it is not so simple?

Preventative pharmaceutical treatments are, culturally, a hard sell unless you have some documented risk factor better than "life". But if you can find a provider that specializes in "anti-aging", it might be the first thing they reach for. Just don't buy into too much of what they say :) I would say anti-cholesterol medications were vastly marketed/sold and prescribed to those likely to only benefit a bit. The "Numb…

The childhood mass vaccinations are individually and collectively effective with few doses and target epidemic diseases, some of which lead to a lifetime of diminished capacity.

The flu vaccine targets a potentially epidemic disease, which can be lethal, but doesn't often leave you with lifetime effects otherwise. Additionally, the vaccine has varied effectiveness from year to year, requires an annual dose. Annecdotally, I know if I get the flue vaccine, I'm going to feel shitty for a couple days; but I don't know that I've ever had the flu -- most of the seasonal illness I've had doesn't seem to match, and of course, you wouldn't know unless you were tested, and no doctor wants you to come in to get tested if you're doing OK at home.

Re: Slow walking at 45 'a sign of faster ageing'

#14

Post by NotSammyHagar »

toast0 wrote: post #13
Scoundreller wrote: post #10

Earlier quoted context omitted.

Preventative pharmaceutical treatments are, culturally, a hard sell unless you have some documented risk factor better than "life". But if you can find a provider that specializes in "anti-aging", it might be the first thing they reach for. Just don't buy into too much of what they say :) I would say anti-cholesterol medications were vastly marketed/sold and prescribed to those likely to only benefit a bit. The "Numb…

The childhood mass vaccinations are individually and collectively effective with few doses and target epidemic diseases, some of which lead to a lifetime of diminished capacity. The flu vaccine targets a potentially epidemic disease, which can be lethal, but doesn't often leave you with lifetime effects otherwise. Additionally, the vaccine has varied effectiveness from year to year, requires an annual dose. Annecdota…

i get the flu vaccine every year, and I got this year's shot 3 days ago. I had a sore arm for a couple of hours (from getting a shot in a muscle i think) that night and it was gone by morning.

Re: Slow walking at 45 'a sign of faster ageing'

#15

Post by NotSammyHagar »

throwaway5752 wrote: post #12
NotSammyHagar wrote: post #8

Earlier quoted context omitted.

Yes, I want to find a doc to prescribe me this and also understands the negatives. Why aren't there more docs doing this kind of stuff? Maybe bc it is not so simple?

Black boxed. Lactic acidosis.

Please elaborate on both sentences, I don't understand.

Re: Slow walking at 45 'a sign of faster ageing'

#17

Post by Scoundreller »

throwaway5752 wrote: post #12
NotSammyHagar wrote: post #8

Earlier quoted context omitted.

Yes, I want to find a doc to prescribe me this and also understands the negatives. Why aren't there more docs doing this kind of stuff? Maybe bc it is not so simple?

Black boxed. Lactic acidosis.

> Lactic acidosis.

That's debunked hysteria leftover from its predecessor compound. We've been giving metformin long enough to see that it isn't causing lactic acidosis.

> Pooled data from 347 comparative trials and cohort studies revealed no cases of fatal or nonfatal lactic acidosis in 70,490 patient-years of metformin use or in 55,451 patients-years in the non-metformin group.

> There was no difference in lactate levels, either as mean treatment levels or as a net change from baseline, for metformin compared to non-metformin therapies.

https://www.ncbi.nlm.nih.gov/pubmed/20393934

In other words, you may find a few case reports of patients taking metformin having LA, but that's because you can have LA without metformin.

Re: Slow walking at 45 'a sign of faster ageing'

#18

Post by Scoundreller »

NotSammyHagar wrote: post #15
throwaway5752 wrote: post #12

Earlier quoted context omitted.

Black boxed. Lactic acidosis.

Please elaborate on both sentences, I don't understand.

See my above post. There was fear that metformin causes lactic acidosis because its predecessor compound did. But the evidence doesn't support that.

Black box warning: Some drug regulators put alerts in a black box on their packaging.

Unfortunately, these same regulators don't revisit these warnings, leading to 'alert fatigue'.

And with non-metformin therapies being far more profitable, the push to get rid of that unnecessary warning isn't there.

Re: Slow walking at 45 'a sign of faster ageing'

#19

Post by Scoundreller »

ollysb wrote: post #11
NotSammyHagar wrote: post #8

Earlier quoted context omitted.

Yes, I want to find a doc to prescribe me this and also understands the negatives. Why aren't there more docs doing this kind of stuff? Maybe bc it is not so simple?

The side effects can be pretty nasty. I took it for 6 months and the stomach pain and diarrhoea never went away. Berberine however acts on the same pathways as metformin and doesn’t cause the side effects. As a bonus you don’t need a prescription to take it.

> stomach pain and diarrhoea never went away

I always wondered if that's what caused the weight loss: destabilization of the digestive system, so you grow to fear overeating/eating crap.

Dunno how one can say they work on the same pathways: we're not really sure how metformin does its thing.

Re: Slow walking at 45 'a sign of faster ageing'

#20

Post by Scoundreller »

toast0 wrote: post #13
Scoundreller wrote: post #10

Earlier quoted context omitted.

Preventative pharmaceutical treatments are, culturally, a hard sell unless you have some documented risk factor better than "life". But if you can find a provider that specializes in "anti-aging", it might be the first thing they reach for. Just don't buy into too much of what they say :) I would say anti-cholesterol medications were vastly marketed/sold and prescribed to those likely to only benefit a bit. The "Numb…

The childhood mass vaccinations are individually and collectively effective with few doses and target epidemic diseases, some of which lead to a lifetime of diminished capacity. The flu vaccine targets a potentially epidemic disease, which can be lethal, but doesn't often leave you with lifetime effects otherwise. Additionally, the vaccine has varied effectiveness from year to year, requires an annual dose. Annecdota…

You might be one of the 75% that don't have symptoms:

https://www.nhs.uk/news/medical-practice/three-quarters-of-p...

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