Sort of.
Though the tumbler was invisible, and hence, not perceptible. You could go through any number of cases of phenomena throughout history, such as the germ theory of disease, prions, electromagnetic force, subatomic particles, or mental health, all of which have, at least by current reckoning, some level of cause or mechanism, but which were seen as beyond description or explanation in the past.
The case especially of moving from some sort of divine or moral explanation, as has been the case for both infectious and (somewhat still the case) mental illness is a critical one. Similarly for natural phenomena (comets, asteroid impacts, earthquakes, volcanoes, cyclonic storms), often seen in the past as portents of the gods / a god, rather than events with specific causal mechanisms.
There are several Big Problems currently facing humanity which are straddling this manifest/not-manifest cusp, with media manipulation and global warming being two of the more prominent.