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Life as a cancer patient: ‘it feels like dying from the drugs meant to save me’

theguardian.com

71–80 of 138 posts

Re: Life as a cancer patient: ‘it feels like dying from the drugs meant to save me’

#71

I am a pancreatic cancer survivor. It is considered incurable in 2019 and I'm here because of a 1930s era surgery called a Whipple procedure. Around 9% survive five years or more -- a number that hasn't really changed. In a belt plus suspenders move I underwent 2 rounds (six infusions per round) of chemo plus 28 consecutive weekdays of radiation after surgery. All my doctors are amazed at my recovery, a few saying th…

Congratulations!

My father unfortunately passed away from the same cancer. 6 months after the diagnosis, having already done 6/8 chemo infusions. His liver was giving up by then. He also went from nearly 90kg to around 42kg in the end.

It is really a terrible cancer. He didn't have any symptoms until the year before his death. By then it was stage 4 already.

I'm abstaining from alcohol since then.

Re: Life as a cancer patient: ‘it feels like dying from the drugs meant to save me’

#72
post #64
post #61

I'm surprised no one has talked about diet here. Not a single one. There are many cases of cancers being completed reversed by change of diet, many cancers survive off of glucose and so switching to a fat based diet has helped many people go into remission as well as dull and intensify the effects of chemotherapy. Cancer is a living biological cell after all and will prefer certain sources of energy over others. Star…

Human brains survive exclusively on glucose, according to your theory they’d die too.

No. They can make use of glucose or ketone bodies. I recommend a biology textbook before commenting on fairly basic and long-established facts.

However, even if they only metabolised glucose, the brain's requirement is for a constant but low level supply. It doesn't need to be provided by a dietary source; the body will synthesise it on demand from its energy stores. The cancer will need to compete for that small quantity with the rest of the body, which will limit its growth.

When you eat sugar, the body can't immediately store it since it takes time to do so, and blood sugar levels spike for a period before reducing back to baseline levels. During this time sugar is in great excess in the bloodstream and tissues, and the cancer is able to utilise as much of it as it can, which can result in its survival and growth.

The survival and growth of a cancer is largely based upon various kinetics, proliferation rates vs death rates, and the evolution of a cancer through selective pressure over time. One of the key switches is to anaerobic metabolism. It lets them switch to lactate production to survive a lack of oxygen. But it comes with a limitation: they are restricted to glucose and other simple sugars to survive. By strictly limiting their availability, it can have a significant effect upon tumour viability. Until it undergoes another change under selective pressure, of course, but it's a simple and potentially very effective course of action, without any great risk of harm.

Re: Life as a cancer patient: ‘it feels like dying from the drugs meant to save me’

#73

I knew two people who both got cancer about the same time. One said no to chemo. The other said yes to chemo. The differences in quality of life until death were dramatic . Neither had a longer life than was expected had they not taken the chemo, but the one who did lost hair, physical dexterity, then life. Suffered greatly. The other one suffered much less, but still died. The doctors all said take the drugs. You do…

My three parents all got cancer. The one that refused chemo was laughed at and insulted by her doctor. She had to make a courageous speach to be treated with respect.

Re: Life as a cancer patient: ‘it feels like dying from the drugs meant to save me’

#74
Visual loss is a very rare side effect of chemotherapy, and permanent visual loss even rarer. The more common and no less serious side effects of heart muscle damage and secondary leukemia are not mentioned in the tagline, being ill-suited as click bait I presume.

I have given the chemotherapy described here to many patients. There is wide variation in how patients experience chemotherapy. Some finish and tell me it wasn't as bad as they expected. I'm quite sure they only tell me things like this in the privacy of the consulting room. They would never say this to another patient in the waiting room. They feel bad for not having had the kind of widely publicised terrible experience.

Beyond the tagline, the account is reasonably accurate, although at times indulges in melodrama, about mitochondria of all things. It also doesn't do a good job of talking about the cognitive dysfunction associated with chemotherapy. This is a complex issue. In randomised trials, patients receiving placebo cancer treatments tend to report high rates of some cognitive problems. That chemotherapy itself is causal in every case is certainly in doubt. The mere experience of being diagnosed with cancer as you might imagine can have profound cognitive effects.

I am not quibbling for the sake of it. There are patients who decide not to have chemotherapy, and sometimes what they have heard about the experience from 'alternate' channels (such as newspaper taglines) has an out-sized influence on their decision. This is why a responsible editorial team would have had this article reviewed by medical professionals and patient advocates, and taken their advice about more judicious highlighting of potential side-effects. The article also doesn't quite deal with the fact that triple negative breast cancer is a really bad disease to have. Metastatic disease has a median overall survival of 18 months. If chemotherapy had not completely eradicated the cancer as it did in her case (the chances are about 50-50), 40% of patients develop metastatic disease in 3 years.

Re: Life as a cancer patient: ‘it feels like dying from the drugs meant to save me’

#75

I am a pancreatic cancer survivor. It is considered incurable in 2019 and I'm here because of a 1930s era surgery called a Whipple procedure. Around 9% survive five years or more -- a number that hasn't really changed. In a belt plus suspenders move I underwent 2 rounds (six infusions per round) of chemo plus 28 consecutive weekdays of radiation after surgery. All my doctors are amazed at my recovery, a few saying th…

Considering your cancer never caused any pain, how did you find out about it?

Not the OP but I had Hodgkins Lymphoma and I was like:

"Hi, I noticed I have this weird lump. This is a lymph node right? And those are supposed to swell up if I'm ill but then go away? Well this lump is two weeks old." - no pain, just I had noticed a lump and I knew that mysterious lumps need to be reported for diagnosis.

I'm told that probably the first person who'd seen Hodgkins before went "Oh, Hodgkins" but of course they didn't say so - I spent most of the next week or two worrying I'd wasted their time with nothing. It took maybe a few weeks, including a needle biopsy and blood tests before somebody actually formally told me I definitely had cancer and that they intended to begin fixing that immediately could I come in the next day to begin chemo?

Last year (so almost twenty years after I had Hodgkins) I thought I'd detected a new lump and that I was also experiencing peripheral neuropathy (finger nerves not working as expected) so I went urgently to my GP. Still no pain. The GP felt the lump, said "That's a sweat gland, they do that" and I realised later the neuropathy was from holding my mouse and keyboard in a bad way, it went away when I stopped. They did find a new lump in my neck (in hindsight I can't believe they could see it but I'd never noticed, I guess I really don't look at mirrors) but it wasn't dangerous although they did a bunch of tests just in case because after all I have a history.

A few people with Hodgkins report pain when drinking (alcohol). It's unclear why that happens, but most have no pain until _very late_. If you wait until the lump hurts you're probably going to die. In other cancers it will vary, obviously if there's a lump in an internal organ you can't necessarily feel that, and in some cases by the time you can feel a lump you're screwed even if it doesn't hurt.

Re: Life as a cancer patient: ‘it feels like dying from the drugs meant to save me’

#76

I knew two people who both got cancer about the same time. One said no to chemo. The other said yes to chemo. The differences in quality of life until death were dramatic . Neither had a longer life than was expected had they not taken the chemo, but the one who did lost hair, physical dexterity, then life. Suffered greatly. The other one suffered much less, but still died. The doctors all said take the drugs. You do…

Same experience with me, except that the one who said no to chemo died, and the other who said yes is still alive and has recovered (yes, after hair loss and other side effects).

"Do the research" - research is what scientists do, not what is achieved by Googling. No medical treatment is 100% perfect, unfortunately, but I and others I know prefer to play the odds rather than not.

Re: Life as a cancer patient: ‘it feels like dying from the drugs meant to save me’

#77

I am a pancreatic cancer survivor. It is considered incurable in 2019 and I'm here because of a 1930s era surgery called a Whipple procedure. Around 9% survive five years or more -- a number that hasn't really changed. In a belt plus suspenders move I underwent 2 rounds (six infusions per round) of chemo plus 28 consecutive weekdays of radiation after surgery. All my doctors are amazed at my recovery, a few saying th…

Considering your cancer never caused any pain, how did you find out about it?

Pancreatic cancer often presents with painless jaundice. The cancer causes a mass which presses on the common bile duct (the bile drainage from the liver), preventing it from being excreted.

Re: Life as a cancer patient: ‘it feels like dying from the drugs meant to save me’

#78

As someone doing cancer research and running a clinical lab, diagnosing cancer every day, I read the accounts of folks with cancer with a certain degree of lachesism. I want to know what this is. I know chickenpox and a broken leg and I know what it's like to have a loved one with cancer. But the thing itself, I do not know. I spend every waking moment thinking about how to hunt cancer. It used to be reflex, now it's…

I have a lot of admiration towards your “obsession”; it way more meaningful than any of mine, so respect! May I ask, in your opinion, what can I do to lower my chances of getting cancer. So far, I monitor grilled meat consumption, do yearly fasts and watch my carbs. I’d appreciate any advice :)

Re: Life as a cancer patient: ‘it feels like dying from the drugs meant to save me’

#79
post #61

I'm surprised no one has talked about diet here. Not a single one. There are many cases of cancers being completed reversed by change of diet, many cancers survive off of glucose and so switching to a fat based diet has helped many people go into remission as well as dull and intensify the effects of chemotherapy. Cancer is a living biological cell after all and will prefer certain sources of energy over others. Star…

It is not so simple. Many kinds of cancer cells can use ketones too.

Re: Life as a cancer patient: ‘it feels like dying from the drugs meant to save me’

#80
post #69
post #62

Earlier quoted context omitted.

It'd be helpful if you're gonna post something that sounds like pseudoscience to post a source with it. With all of the studies covering inane things, someone has got to have studied this.

It didn't have a source, but it's not pseudoscience. The switch to anaerobic glucose metabolism is part of the evolution of cancer as it progresses. This is because oxygen diffusion into a solid tumour is a limiting factor upon its growth. Cells which switch off aerobic metabolism will be selected for, since only they will survive and proliferate in an oxygen-free environment. You'll find this in most cancer textbook…

It's been debunked. See this post explaining why.

https://scienceblog.cancerresearchuk.org/2017/05/15/sugar-an...

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