If your allocator calls mmap or an equivalent, and the OS gives you back a pointer that uses all 64 bits (or more than 48, anyway) then what do you do? I guess the allocator has to retry and pray, or maybe just give up and fail. In any event your clever code is not going to work well, since you have made a choice that is non-portable.
I imagine that the guy on the MacOS team who stuffed some desk accessory bits into the high byte of a pointer parameter thought he was being clever. Four or five years down the line he was paying for it, and it took years to fix his original moment of convenience. He could have added a second parameter on the call in question, or allocated another byte in a struct, and the original system would have been slightly bigger but he wouldn't have hatched a nightmare. Go read about '32-bit clean' Mac applications if you don't believe me. It sucked real hard.
A bunch of companies with a bunch of smart people have made the decision to use "unused" high bits in pointers and have later regretted it, to the tune of a ton of expensive remedial engineering. I see a lot of talk here along the lines of "b-b-b-but we know what we're doing" and "oh, 48 bits is enough, and if it's not then we'll deal with it later" and I'm thinking, "This is precisely how the software industry just never learns."
I figure that I have about 20 years left in my career writing software. I've seen address spaces grow from 16 bits (and we used to think "wow, that's BIG") to 64 bits [okay, 48 bits if you're still in denial :-) ] and wow, that's big. But I'll bet I'll see 64 bits generally considered kind of tight before I retire, and I'll bet there are at least half a dozen people on the planet who are up against a 64-bit wall today. (High probability at least a couple of those folks are on HN. Any hands?).