This apparently isn't a popular opinion, but: this world is precious. I would even go so far as to say miraculous . Until we wake up to this fact, we will continue to ennui ourselves and this world into oblivion. It's hard to prove (or even study), but I believe this is the root cause of all the other tragedies. It is not something we will merely engineer our way out of. We don't like religion (or in many cases, even…
Here is an attempt at a framework to think about this: we have no proof that life exists anywhere else in the Universe. There is a possibility that life itself arose only once and that we are the only intelligent beings around. We have a sort of grand astronomical duty to not fuck it up and expand to the stars and keep the fire going.