This is a long-winded rant that seems to boil down to advocating for avoiding frameworks altogether. Not worth the watch. TLDW: “the whole point behind this video, guys, is maybe we should ditch React because all of these changes are because of short-sighted architecture, and maybe we all shouldn’t just be these herd animals that are constantly taking and following the herd from one section of the field to the other…
Sounds like he's never had to develop a complex stateful application. In the comments he suggests we can get away with just using "raw js and a decent MVC framework", which becomes unmaintainable very quickly.
There is no such thing that raw/vanilla js is unmaintable, what is unmaintainable is stuff that breaks regulary and vanilla/raw js never(almost?) breaks.