Playing out as Naval Ravikant predicted on the After-on podcast: https://after-on.com/episodes-31-60/044 Eventually cheap drones, anonymous assassination markets, etc. will make commercial flying a thing of the past. Written summary of podcast - https://podcastnotes.org/2019/03/20/after-on-naval-01/
No amount of jamming helps you here, this is radio control off, GPS off, entirely visual "guided missile" approach.
And this approach scales, with 20 drones, 2 drones assigned to each engine, you can engage 5 taking off planes in a row off a busy airport. And you can pick the direction which will make the planes crash in the nearby city.
With a "hire people to do stuff for bitcoin" project (there are several) you can prepare this in a bunch of countries (you just tell them you need some drones setup for an aerial shooting/light show or something).
The future is scary.