For me, it's hit and miss.
Mentally, I'm mostly alright, but under a fair amount of professional and personal stress. The personal stress is mostly due to medical and financial issues (trying to get my wife to live within a budget).
Physically, that's where I break down. I'm not quite 40, and I already have a number of chronic medical issues that are largely beyond my control. The worst of it is osteoarthritis in every thoracic and cervical vertebrae coupled with bone spurs and degenerative discs in the same. Short of it means I'm in pain every day. On a good day, I'm sitting at a 4 in the 1 to 10 pain scale. Sleep funny and tweak a back or neck muscle, I can hit an 8 or 9 easily. Pain bad enough it causes me to vomit. Docs dont/won't prescribe pain meds because of the opiode crisis, which is fine, because the pain I have doesnt respond to opposes anyway. But, makes them reluctant to prescribe meds that might help with the nerve pain, such as Lyrica.
I also suffer from Cyclical Vomitting Syndrome which means every 3 to 6 months, I start vomitting uncontrollably for no apparent reason. No infection, no flu, no food poisoning, no allergy, I just start vomiting about every hour for days on end if untreated. I have to go to the ER every time it happens. Sometimes I get sent home after a few hours and some IV fluids and antinausea meds, other times like this past week, I get admitted because my blood chemistry is so out of whack it looks like I'm about to have a heart attack, am undergoing kidney failure or it looks like I'm diabetic, or all of the above. I spent 4 days in the hospital last week. That stay caused me to miss other scheduled appointments with specialists and an MRI to check on organs due to a genetic condition.
The kicker? I feel great. The docs dont know what causes it, although there's about a 90% correlation with heavy marijuana usage (I've never smoked weed).
Iunno, I have a referral to a specialist a few hours drive away. Need to schedule that appointment...