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Malaria breakthrough as scientists find ‘highly effective’ way to kill parasite

theguardian.com

11–20 of 118 posts

Re: Malaria breakthrough as scientists find ‘highly effective’ way to kill parasite

#11

>science journalism I think this is the case for pretty much every area of journalism. If you are a subject matter expert, you quickly realize that 90% of coverage of that subject is dreadful.

Yes, the Gell-Mann amnesia effect [1] needs to be made more widely known.

[1] https://en.wikipedia.org/wiki/Michael_Crichton#GellMannAmnes...

Re: Malaria breakthrough as scientists find ‘highly effective’ way to kill parasite

#12

>science journalism I think this is the case for pretty much every area of journalism. If you are a subject matter expert, you quickly realize that 90% of coverage of that subject is dreadful.

I know it's really popular these days to shit on journalists, and I agree that the quality of some outlets can be less then desirable, but it is an incredibly difficult field that involves a lot of work, little pay, little thanks, and terrible job security.

Looking at this article, there is no Author by-line, but just the "Global Health" topic. Digging in, their Global Health topic is managed by their "Global development" team, which has a single writer assigned to it on their Contributors page [1]. I am sure free lancers contribute to this section as well, but I am trying to illustrate that this team/writer is probably on the bottom of the totem pole when it comes to resources and priority. If this story would never have been written if it had to pass HN's level of scientific article standards.

[1]: https://www.theguardian.com/index/contributors

Re: Malaria breakthrough as scientists find ‘highly effective’ way to kill parasite

#13
post #11

>science journalism I think this is the case for pretty much every area of journalism. If you are a subject matter expert, you quickly realize that 90% of coverage of that subject is dreadful.

Yes, the Gell-Mann amnesia effect [1] needs to be made more widely known. [1] https://en.wikipedia.org/wiki/Michael_Crichton#GellMannAmnes...

What I want is a name for the related effect:

You read an article on your topic of expertise, it’s bullshit, you read another article, a relevant expert on it pipes up that “that’s bullshit!”, and the prevailing response is, “no, you’re wrong, I’ve read a bunch of articles on this topic.”

That is, the Gell-Mann effect as a justification for over-ruling expert criticism.

Re: Malaria breakthrough as scientists find ‘highly effective’ way to kill parasite

#14

Earlier quoted context omitted.

This kind of experiment is called a gene drive, and there's a huge debate in scientific communities right now around whether it's responsible or not to use them, particularly around the mosquito problem. A professor of mine who works in the field was discussing this with us last week. The idea with mosquitoes specifically is that we can wipe out specifically the mosquito populations that carry most diseases. The deba…

> This is just my interpretation, but it seems like there is a sensible portion of detractors who simply want to derisk the experiment as much as possible by collecting more and more data. This is so infuriating. Many people will die during this extended hemming and hawing. Humans have driven countless important species to extinction with no thought, but we have to vacillate over a species that is responsible for mor…

Wanting any creature to suffer seems ... problematic.

That goes for wanting humans to suffer too: even the most "evil" among us are doing the best they know how, for some value of "best" that their brains arrive at as a result of the genetic lottery and the "programming" that they've had as a result of their lifetime of experiences. That certainly doesn't mean that we shouldn't vigorously oppose some of the things that such folks try to do. But at least an effort at compassion should be the default response. (As a certain Middle Eastern sage is reputed to have said circa 2,000 years ago: Love your enemies.)

Re: Malaria breakthrough as scientists find ‘highly effective’ way to kill parasite

#15

>science journalism I think this is the case for pretty much every area of journalism. If you are a subject matter expert, you quickly realize that 90% of coverage of that subject is dreadful.

All journalism to the sufficiently informed looks like pathos. All journalism to the sufficiently uninformed looks like logos.

Re: Malaria breakthrough as scientists find ‘highly effective’ way to kill parasite

#16
post #4
post #2

This article can’t seem to decide whether it’s discussing ivermectin - an old antiparasitic derived from the avermectin produced by streptomyces - or bacteria. It vacillates between “ivermectin effective” and “bacteria killed parasite,” which are in no way equivalent. The latter suggests something like “strep killed plasmodium, so maybe we can find the compound used and use it for malaria.” The latter suggests, well,…

It almost sounds as if the journalist believes Ivermectin _is_ a bacteria and a drug derived from it is killing malaria. Agreed that this smacks of sloppy science journalism.

I think you are right. Here is a quote from the author, who is obviously talking about a bacterium killing plasmodium, of which ivermectin is not.

“We have discovered [that the] bacterium is highly effective in killing plasmodium falciparum, the parasite that causes malaria, but our research is more focused on pregnant women and children as they are more vulnerable. We are getting very motivating leads,” Kariuki said.

Perhaps the issue is that Kariuki is not a listed author on the Lancet paper, so perhaps he's just providing comment generally and not specifically?

Re: Malaria breakthrough as scientists find ‘highly effective’ way to kill parasite

#17
post #2

This article can’t seem to decide whether it’s discussing ivermectin - an old antiparasitic derived from the avermectin produced by streptomyces - or bacteria. It vacillates between “ivermectin effective” and “bacteria killed parasite,” which are in no way equivalent. The latter suggests something like “strep killed plasmodium, so maybe we can find the compound used and use it for malaria.” The latter suggests, well,…

https://en.wikipedia.org/wiki/Ivermectin

Ivermeticin is commonly used in Veterinary medicine for cattle, horses, sheep, goats, dogs, etc. It is once in a while used to treat worms in people but is more common to use Pyrantel to treat human roundworm infections which are surprisingly common in developed countries.

Thus it is a common drug and will not be crazy expensive. It seems expensive to me when I have to buy it for an animal bigger than me at first world prices, but it is cheap in developing countries.

Re: Malaria breakthrough as scientists find ‘highly effective’ way to kill parasite

#18
post #2

This article can’t seem to decide whether it’s discussing ivermectin - an old antiparasitic derived from the avermectin produced by streptomyces - or bacteria. It vacillates between “ivermectin effective” and “bacteria killed parasite,” which are in no way equivalent. The latter suggests something like “strep killed plasmodium, so maybe we can find the compound used and use it for malaria.” The latter suggests, well,…

This science journalism isn't all that bad, actually. The article is clearly about Ivermectin, and never mentions "bacteria killed parasite" - Additionally, Ivermectin and other avermectins are macrocyclic lactones and are derived from the bacterium Streptomyces avermitilis. So even if teh article mentions bacteria... it's still not wrong.

Re: Malaria breakthrough as scientists find ‘highly effective’ way to kill parasite

#19

Earlier quoted context omitted.

This kind of experiment is called a gene drive, and there's a huge debate in scientific communities right now around whether it's responsible or not to use them, particularly around the mosquito problem. A professor of mine who works in the field was discussing this with us last week. The idea with mosquitoes specifically is that we can wipe out specifically the mosquito populations that carry most diseases. The deba…

>Then there are others who are in general opposed to this sort of interference in an animal population on ethical grounds. There are over 250,000 children under the age of 5 that die every year from malaria. In my ethical system, there is very little that can possibly justify trying to prevent something that will save the lives of 250,000 children a year. Anyone who actively tries to delay wiping out malaria causing…

There are legitimate concerns about efficacy (there’s research that suggests that evolution will help mosquitoes escape the gene drive effect, making it useful for only a short period of time) and about unknown ecological consequences (knocking out a primary food source in an ecosystem can have devastating health and economic consequences). That’s not to say it’s not worth it, but it is worth debating and figuring out how to do it correctly. I don’t think it’s fair to say there’s a silver bullet that is being held up by ignorant/uninformed/unethical skeptics.

Re: Malaria breakthrough as scientists find ‘highly effective’ way to kill parasite

#20
As a kid growing up in Malaria country I got yellow jaundice. Doctor told my dad that since I had had yellow jaundice I was "immune" to malaria. Its been 35 odd years since I have taken any malaria medication. Family members often get malaria once or so a year. A few years ago I decided to check to see if there were was any literature online with link between Malaria and jaundice. I couldn't find any papers online. Now I don't know whether what the doctor told my dad was true or there is something to be said about me having mentally told myself I am immune to malaria. To this day my dad maintains I cannot get malaria. The younger me believed him wholeheartedly, the older me would be grateful for some research papers on the topic.
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