Magnesium is also a part of this!
Effect of High-Dose Vitamin D on Volumetric Bone Density and Bone Strength
21–30 of 75 posts
Re: Effect of High-Dose Vitamin D on Volumetric Bone Density and Bone Strength
#22A larger, longitudinal study would be awesome for establishing other Vitamin D claims (in particular, reduced MS incidence and reduced cancer incidences)
Re: Effect of High-Dose Vitamin D on Volumetric Bone Density and Bone Strength
#23Why are there so many studies looking at vitamin D and bone health? Vitamin D levels affect expression of over 400 genes in the human body, make a difference in cancer survival and are strongly inversely correlated with all cause mortality ( https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103214/ https://www.mdedge.com/psychiatry/article/66349/depression/v... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201256/ ). Doe…
Bones and SAD.
Re: Effect of High-Dose Vitamin D on Volumetric Bone Density and Bone Strength
#24Why are there so many studies looking at vitamin D and bone health? Vitamin D levels affect expression of over 400 genes in the human body, make a difference in cancer survival and are strongly inversely correlated with all cause mortality ( https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103214/ https://www.mdedge.com/psychiatry/article/66349/depression/v... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201256/ ). Doe…
Yes
Re: Effect of High-Dose Vitamin D on Volumetric Bone Density and Bone Strength
#25The results confuse me. Taking 4000 or 10,000 IU results in lower bone mineral density than 400. Is lower BMD better? Otherwise it sounds like vitamin D is actually bad for you.
Yes, it appears that too much vitamin D may decrease bone density.
Re: Effect of High-Dose Vitamin D on Volumetric Bone Density and Bone Strength
#26Why are there so many studies looking at vitamin D and bone health? Vitamin D levels affect expression of over 400 genes in the human body, make a difference in cancer survival and are strongly inversely correlated with all cause mortality ( https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103214/ https://www.mdedge.com/psychiatry/article/66349/depression/v... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201256/ ). Doe…
Time to start taking vitamin D
Re: Effect of High-Dose Vitamin D on Volumetric Bone Density and Bone Strength
#27To preface here, what I'm to share goes beyond what's in the article. That said, I worked for years in a clinical "bone lab" (and at a notable university hospital with respect to this area of research) investigating bone wasting diseases; namely, idiopathic hypercalciuria, and osteopenia & osteoporosis.
Not say that lends me too much authority on the matter, but many of the biological effects of D3 are pretty poorly understood, still. Simplifying a bit, this can be chalked up to the fact that it's roles in molecular networks across the systems are myriad, and of these, many of its (downstream) effects seem -- and, if not, are -- contradictory. (To the initial point, in it's bioactive form, it's classified as a hormone.)
At high dosages, typically what's found it many OTC supplements (5-10K IUs vs 500 IU daily allowance), there is evidence that it facilitates significant bone resorption.
So not only does it not strengthen bones, D3 actively makes it more brittle. Typically, this is linked to inadequate calcium & phosphate minerals to match the excess D3 (and these minerals in excess introduce additional problems of their own).
I didn't cite literature here but it is readily available & abundant (But I can pull some if anyone would like). And, within it, there is a glaring lack of consensus. And hence, why my language is couched in so many conditionals.
Re: Effect of High-Dose Vitamin D on Volumetric Bone Density and Bone Strength
#28To preface here, what I'm to share goes beyond what's in the article. That said, I worked for years in a clinical "bone lab" (and at a notable university hospital with respect to this area of research) investigating bone wasting diseases; namely, idiopathic hypercalciuria, and osteopenia & osteoporosis. Not say that lends me too much authority on the matter, but many of the biological effects of D3 are pretty poorly…
If you exceed calcium and phosphates intake by an amount sufficient to compensate for the excess D3, does that "do the trick" or is that a bad hack? I've seen certain 9 pills a day multivitamin formulations who deliver much much higher than the daily dose of everything, I think Life Extension sells them, and I'm wondering if they are hip to these facts.... I used to buy their vitamins. Now I just take the ones that are one a day pill instead of 9, and those never exceed the daily IUs.
Another question for you, does supplementation work as intended when our diet is insufficient, or is it just a gimmick? I've always wondered about this. By work, I mean, if you were to have a blood test in two parallel trials, one where you supplemented but had a crappy diet and another where you ate the "perfect" diet that supplied the daily IU needs, would the blood work show equal amount of each mineral/vitamin/etc in both cases?
Re: Effect of High-Dose Vitamin D on Volumetric Bone Density and Bone Strength
#29To preface here, what I'm to share goes beyond what's in the article. That said, I worked for years in a clinical "bone lab" (and at a notable university hospital with respect to this area of research) investigating bone wasting diseases; namely, idiopathic hypercalciuria, and osteopenia & osteoporosis. Not say that lends me too much authority on the matter, but many of the biological effects of D3 are pretty poorly…
One of the big asterisks with most D3 bone density studies(and is applicable to this one) is that they are studying older adults specifically, vs, say, athletes. There are bodybuilders, for example, who swear by high-dose D3.
Re: Effect of High-Dose Vitamin D on Volumetric Bone Density and Bone Strength
#30To those who only read the HackerNews title and not the title of the actual article, it does not say that Vitamin D does not strengthen bones, but rather higher does don't seem to strengthen more than lower doses, not compared to not taking any at all as one would probably interpret from the HackerNews title.