Effect of High-Dose Vitamin D on Volumetric Bone Density and Bone Strength
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Re: Effect of High-Dose Vitamin D on Volumetric Bone Density and Bone Strength
#2I thought calcium had a bigger impact on bone density than Vitamin D?
Re: Effect of High-Dose Vitamin D on Volumetric Bone Density and Bone Strength
#3I thought calcium had a bigger impact on bone density than Vitamin D?
Many doctors will prescribe D megadoses for patients with at-risk bone density. I guess this is saying to not do that.
Re: Effect of High-Dose Vitamin D on Volumetric Bone Density and Bone Strength
#4So high doses reduce mineral density but have no effect on strength? How is that possible? Is strength not a function of density?
Re: Effect of High-Dose Vitamin D on Volumetric Bone Density and Bone Strength
#5Headline is imprecise. The study is saying that higher doses of vit D do not strengthen bone more than lower doses, not that they don't strengthen bone at all, which is suggested by this headline.
Re: Effect of High-Dose Vitamin D on Volumetric Bone Density and Bone Strength
#6I thought you needed both vitamin D and vitamin K2 - D to mobilize the calcium and K2 to put it into the right place.
Re: Effect of High-Dose Vitamin D on Volumetric Bone Density and Bone Strength
#7Headline is imprecise. The study is saying that higher doses of vit D do not strengthen bone more than lower doses, not that they don't strengthen bone at all, which is suggested by this headline.
>Interventions: Daily doses of vitamin D3 for 3 years at 400 IU (n = 109), 4000 IU (n = 100), or 10 000 IU (n = 102). Calcium supplementation was provided to participants with dietary intake of less than 1200 mg per day.
>Main Outcomes and Measures: Co-primary outcomes were total volumetric BMD at radius and tibia, assessed with high resolution peripheral quantitative computed tomography, and bone strength (failure load) at radius and tibia estimated by finite element analysis.
>Conclusions and Relevance: Among healthy adults, treatment with vitamin D for 3 years at a dose of 4000 IU per day or 10 000 IU per day, compared with 400 IU per day, resulted in statistically significant lower radial BMD; tibial BMD was significantly lower only with the 10 000 IU per day dose. There were no significant differences in bone strength at either the radius or tibia. These findings do not support a benefit of high-dose vitamin D supplementation for bone health; further research would be needed to determine whether it is harmful.
Headline is not imprecise according to above-cited Conclusions and Relevance.
Re: Effect of High-Dose Vitamin D on Volumetric Bone Density and Bone Strength
#8Headline is imprecise. The study is saying that higher doses of vit D do not strengthen bone more than lower doses, not that they don't strengthen bone at all, which is suggested by this headline.
>Interventions: Daily doses of vitamin D3 for 3 years at 400 IU (n = 109), 4000 IU (n = 100), or 10 000 IU (n = 102). Calcium supplementation was provided to participants with dietary intake of less than 1200 mg per day. >Main Outcomes and Measures: Co-primary outcomes were total volumetric BMD at radius and tibia, assessed with high resolution peripheral quantitative computed tomography, and bone strength (failure l…
> Headline is not imprecise according to above-cited Conclusions and Relevance.
No, aladoc99 is right, because the study doesn't compare against 0. So you don't know if 4000 and 10000 improve strength compared to 0, only that they don't compared to 400. It's not a hill that someone should die on, though.
Re: Effect of High-Dose Vitamin D on Volumetric Bone Density and Bone Strength
#9In other words, a lack of Vitamin D reduces bone strength but getting more than necessary doesn't increase bone strength any further.
Makes sense. This is often how the body works. You should get enough of but having more than needed doesn't turn you into a superhero (but it can be poisonous).
Re: Effect of High-Dose Vitamin D on Volumetric Bone Density and Bone Strength
#10I thought calcium had a bigger impact on bone density than Vitamin D?
Generally the greatest way to increase bone density is to lift "heavy" weights. Compared to that any other solution pales in comparison but doctors never seem to prescribe that.