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In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

nature.com

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Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

#171

Post by newnewpdro »

Kaiyou wrote: post #151
newnewpdro wrote: post #146

Earlier quoted context omitted.

I have never heard someone refer to abstaining from alcohol as fasting. Cleansing, or detoxing, yes. Fasting, no. The people around you are simply misusing the term.

I've also heard it in relation to not eating meat, not eating candy and not eating various other categories of food. Never have I heard it in a meaning of not consuming anything at all, however.

Maybe it's common in a religious context?

Fasting meaning abstinence from food is fairly well-established. Breakfast is literally break-fast, with the fasting period being overnight while you slept.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

#172

Post by qnsi »

AnIdiotOnTheNet wrote: post #164
yhoneycomb wrote: post #154

Earlier quoted context omitted.

I’ve been doing it for about a year and a half, just skipping breakfast each day and lunch one or two workdays a week. At this point, most days it’s not even hard. When I’m hungry I just realize that the hunger is temporary, and it’s honestly unrelated to the degree to which I need food. And tbh nowadays I can tell when my body actually feels weak and needs food, and when it’s just whining. I think of it like getting…

> I’ve been doing it for about a year and a half, just skipping breakfast each day and lunch one or two workdays a week. You call that a fast? As someone who's lost and kept off about half their body weight, I feel qualified to tell you that skipping a meal here and there is not fasting. In fact, if you're eating every day you're not fasting. Fuck, I mean, I only eat about 1.5 meals a day as a requirement of merely m…

this is just different definition of what fasting is. What he's doing is time-restricted eating but it is a form of fasting. You are just doing longer fasts. No need to gatekeep

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

#173

Post by qnsi »

Iv wrote: post #160
SmellyGeekBoy wrote: post #149

Earlier quoted context omitted.

Yes. Hormone injections, "strange" diets, taking supplementation to extremes etc. As with any group there are people who follow it to varying degrees. (I'm not an "antiaging enthusiast" other than eating healthy and regular exercise but I have done some reading on the subject)

What is the easiest step you recommend?

I think "easiest" is sauna. Exercising is good because it can also help with your mood and brain functioning. I heard conflicting information about cold shocks. There is also fasting which as top comment said works similarly to original link.

If you want to read for example about sauna I recommend thishttps://www.foundmyfitness.com/topics/sauna she also has a lot of stuff about other things I mentioned

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

#175

Post by red75prime »

jjoonathan wrote: post #7
tobr wrote: post #2

9 people, no control group.

"Enough for Nature! Next time, let's see if we can get away with 8!"

I would say that even one person experiment with documented deep reversal of age-related changes deserves publication and further research.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

#176

Post by darkerside »

powersnail wrote: post #88
darkerside wrote: post #79

Earlier quoted context omitted.

Why do you say that? Biology is usually very simple. Eat food, live. Don't eat food, die. Drink water, live. Don't drink water, die. Just because you don't happen to know the answer doesn't mean the answer is complicated.

Just because you can say something in four words, doesn’t mean it is simple. You eat, you live. Sure. But why? What happens to the things you eat? What can you eat? What/how/why is the pain in your stomachs?

Ugh, please take it in context. That was in response to something.

> There's not going to be a single magic compound. Slowing the aging process is massively complex and will probably require a cocktail of treatments

My counterpoint is, slowing aging could easily be the result of a very simple compound. It's irrational to assume it must be complex just because we don't know it.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

#177

Post by jjoonathan »

red75prime wrote: post #175
jjoonathan wrote: post #7

Earlier quoted context omitted.

"Enough for Nature! Next time, let's see if we can get away with 8!"

I would say that even one person experiment with documented deep reversal of age-related changes deserves publication and further research.

The fact that it deserves further research is precisely why we shouldn't frontload the prestige incentives. That's how you get clickbait. We don't want clickbait, we want further research, but if we incentivize based on clickbait, clickbait is all we're going to get. Let's not.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

#178

Post by 01100011 »

huherto wrote: post #123
01100011 wrote: post #120

Earlier quoted context omitted.

Metformin is great. A doc even recommended it to my friend while he was fighting a glioblastoma(brain cancer). I'd love to take it but I tried berberine, which is supposedly similar in effect, and got major low blood sugar. The only issues with Metformin are occasional digestive issues(diarrhea) and the slight chance of lactic acidosis.

Sorry about your friend. How is Metformin helpful for glioblastoma ? My sister has this. How is your friend doing? Any lessons?

I think the metformin was part of a shotgun approach used by the docs at UCSD. My friend's brothers were aggressively pushing treatment when it was clearly inoperable so that may have had something to do with it. My friend lasted a single, horrible year and passed away a few years ago.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

#179

Post by bennylam »

Though it happened some times ago, the TRIM clinical trial was really a real small scale research. According to the following info: http://interveneimmune.com/?ignition_product=the-triim-trial

http://interveneimmune.com/?page_id=1200 This company is found by Greg Fahy, PhD, Chief Scientific Officer, Co-founder -Published the first report of thymus regeneration in a normal human; Granted patents on methods for and applications of human thymus regeneration –Fellow of the American Aging Association (since 2005), Former Director of the American Aging Association (16 years) –Editor-in-Chief, The Future of Aging: Pathways to Human Life Extension –Awarded the Society for Cryobiology’s Luyet Medal in 2016 –In 2009, showed indefinite survival of rabbit kidney transplanted after cooling to -130° Celsius; Led 21CM team as co-winner of Small Mammal Brain Preservation Prize, 2018 winner of Large Mammal Brain Preservation Prize and Steve Horvath, PhD, Scientific Collaborator -Professor of Human Genetics & Biostatistics at UCLA -Developer of the DNA methylation clock of human aging, as well as author of seminal papers demonstrating ability to accurately predict life expectancy, onset of Alzheimer's, cognitive decline, and more -Paul G. Allen Distinguished Investigator -Ph.D. Mathematics at UNC, Sc.D. Biostatistics from Harvard University

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

#180

Post by Tringi »

qnsi wrote: post #174
ThinkBeforeDo wrote: post #105

Where's a link to the actual paper/ peer-reviewed publication?

Should be here but can't get it on sci-hub Fahy, G. M. et al. Aging Cell https://doi.org/10.1111/acel.13028 (2019).

I'm searching for it too, and I can't find the actual text. Somebody doesn't want us to begin mixing that cocktail ourselves :D
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