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In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

nature.com

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Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

#151

Post by Kaiyou »

newnewpdro wrote: post #146
Kaiyou wrote: post #145

Earlier quoted context omitted.

What is fasting anyway? Some people tell me they "fast" by drinking no alcohol. Others say they fast by only drinking water and not eating anything at all. Why does everyone have to use the word so differently..

I have never heard someone refer to abstaining from alcohol as fasting. Cleansing, or detoxing, yes. Fasting, no. The people around you are simply misusing the term.

I've also heard it in relation to not eating meat, not eating candy and not eating various other categories of food. Never have I heard it in a meaning of not consuming anything at all, however.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

#152

Post by coldtea »

zarkov99 wrote: post #93
coldtea wrote: post #54

Earlier quoted context omitted.

Or, well, victorian tiptoeing around language becoming popular again, to avoid saying the obvious: most rich people in our society are white...

Yes, and that is what one would expect when most people are white in the first place.

That would be relevant if the distribution was in any way proportional to the general population...

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

#153

Post by badestrand »

jvagner wrote: post #96
stickfigure wrote: post #62

Earlier quoted context omitted.

Your idea of 'fun' and my idea of 'fun' are wildly different.

The idea of fasting and the reality of fasting are different. The idea is more painful than a committed effort. Once you accept and embrace the fast, it’s freeing. Like running every day.... once you know you’re going to do it, the resistance withers.

After doing intermittant fasting for half a year I think you shouldn't generalize too much from your own experience. Yes, it gets easier but it stays painful and requires a lot of willpower ime.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

#154

Post by yhoneycomb »

badestrand wrote: post #153
jvagner wrote: post #96

Earlier quoted context omitted.

The idea of fasting and the reality of fasting are different. The idea is more painful than a committed effort. Once you accept and embrace the fast, it’s freeing. Like running every day.... once you know you’re going to do it, the resistance withers.

After doing intermittant fasting for half a year I think you shouldn't generalize too much from your own experience. Yes, it gets easier but it stays painful and requires a lot of willpower ime.

I’ve been doing it for about a year and a half, just skipping breakfast each day and lunch one or two workdays a week.

At this point, most days it’s not even hard. When I’m hungry I just realize that the hunger is temporary, and it’s honestly unrelated to the degree to which I need food. And tbh nowadays I can tell when my body actually feels weak and needs food, and when it’s just whining.

I think of it like getting sleepy. Just because I feel sleepy doesn’t mean I should just take a nap right there and then.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

#156

Post by James_Henry »

nikolay wrote: post #129
James_Henry wrote: post #103

Earlier quoted context omitted.

Do you know how strong the placebo works on Horvath's epigenetic clock? I don't think that research has been done, but it will be soon I am sure and it will be incredibly interesting to find out. Even without knowing that though, I'm surprised, and so is Horvath himself, that they found a full-on reversal of the clock. I don't think anyone was expecting that. I'm betting we won't see that kind of reversal in a future…

The placebo itself is magical enough so it could be extended to pretty much anything and that's why quality studies are done certain way. If can understand the placebo, then and only then we can then explain what it could do and it can't do.

This is false. We can explain a lot without a placebo comparison. Also, the placebo isn't magic, we just haven't studied exactly what it is. It clearly does have limitations: look at all the studies where the placebo only does so much!

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

#157

Post by James_Henry »

nikolay wrote: post #130
ALittleLight wrote: post #111

Earlier quoted context omitted.

The article mentions the effects persisted even a year after treatment. That's far beyond the placebo effect for anything I'm aware of.

The placebo effect can definitely extend beyond the end of the trial.

Sure, but we know how it often acts in trials.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

#158

Post by balfirevic »

mayankkaizen wrote: post #139
stickfigure wrote: post #62

Earlier quoted context omitted.

Your idea of 'fun' and my idea of 'fun' are wildly different.

There was a time I wouldn't wake up early. I enjoyed sleeping till late morning. At that time I was kind of unable to feel why people who wake up early insist that it is more enjoyable than sleeping till 9 AM. Then I develop this habit of waking up early. Initially I wasn't very comfortable but now I too can say it is more enjoyable. I guess you get the point.

Damn, I had to do a double take on this. 9 AM is super early for me, noon is normal and 2-3 PM is sleeping late. What is appealing and tolerable will not be the same for everyone and sometimes it's not just a matter of getting used to something. It's hard to say in advance.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

#159

Post by [deleted] »

Kaiyou wrote: post #151
newnewpdro wrote: post #146

Earlier quoted context omitted.

I have never heard someone refer to abstaining from alcohol as fasting. Cleansing, or detoxing, yes. Fasting, no. The people around you are simply misusing the term.

I've also heard it in relation to not eating meat, not eating candy and not eating various other categories of food. Never have I heard it in a meaning of not consuming anything at all, however.

[deleted]

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

#160

Post by Iv »

SmellyGeekBoy wrote: post #149
Iv wrote: post #97

Earlier quoted context omitted.

> antiaging enthusiasts Never heard of that crowd. What is it that they do? Try experimental treatments on themselves?

Yes. Hormone injections, "strange" diets, taking supplementation to extremes etc. As with any group there are people who follow it to varying degrees. (I'm not an "antiaging enthusiast" other than eating healthy and regular exercise but I have done some reading on the subject)

What is the easiest step you recommend?
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