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U.S. Surgeon General’s Advisory: Marijuana Use and the Developing Brain

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251–260 of 352 posts

Re: U.S. Surgeon General’s Advisory: Marijuana Use and the Developing Brain

#251
Talking about Marijuana as this singular substance is demeaning the details. Different types, strains, turpen profiles, cbd levels, cbn levels all change the effects.

Does a higher cbd amount change the data? What about changing the levels of thc. Does hindu kush provide less anxiety vs purple haze over time?

It feels like it's way to early to draw grand conclusions.

Re: U.S. Surgeon General’s Advisory: Marijuana Use and the Developing Brain

#252
post #84

Earlier quoted context omitted.

So that's as far as you got? Didn't like the domain, therefore the study results are bunk? 75% of the authors are affiliated with other institutions, only 3 are with the National Institute on Drug Abuse. NIDA itself is well-grounded. There have been some instances where they take a more conservative stance given uncertainty in results, but this is still a national scientific institute - not DARE or the DoJ. Finally,…

Would you care to speculate again about how much time I've spent reading their literature before this discussion? I promise you, it's non-zero. Please try not to dismiss people's positions that shallowly; it's a disservice to the conversation we're trying to have, and it's rude. I am involved in a number of communities that engage intentionally, even sacramentally, with psychedelics. The amount of sheer bullshit they…

Not OP, but FWIW your italicizing of drugabuse.gov also gave me the impression that you were dismissing it purely by domain. I did not ready any rudeness in your parent.

Re: U.S. Surgeon General’s Advisory: Marijuana Use and the Developing Brain

#253

Earlier quoted context omitted.

I appreciate this honest statement. I work daily with individuals with mental disabilities including psychosis, memory dysfunction, and perceptional disturbances, and can certainly agree from what I have subjectively seen. (Though also longitudinally as I have viewed medical records extensively over years and years of research). I have witnessed secondhand that higher doses and earlier use of THC are more likely to p…

Completely off-topic here, my apologies. If I wanted to talk with someone about memory dysfunction, who would that be? It's something that I've begun to notice in myself and I'd love to know more about what you do, with the hopes of finding a professional to speak with about my concerns.

Therapist for understanding and coping of the mind, psychiatrist for medicine to address mental dysfunction and illness

Both likely covered by insurance. And stop smoking weed.

Re: U.S. Surgeon General’s Advisory: Marijuana Use and the Developing Brain

#254

Earlier quoted context omitted.

Anecdote like this is bad for two reasons: 1) How do you know you wouldn't have done better had you not smoked starting in high school? You can't go back in time and A/B test yourself 2) Your personal physiology may be fine with marijuana use, but that's not a guarantee that the same applies to everyone else. I'm sure plenty of HN readers (myself included) knew people in high school who did suffer from marijuana-rela…

> 1) How do you know you wouldn't have done better had you not smoked starting in high school? You can't go back in time and A/B test yourself It's just high school :) if GP passed and moved on, who cares? High school success becomes more and more of a boolean outcome as you get further away from it imo. And tbh even boolean is generous. "I wish in the past I had tried more things 'cause now I know that being in trou…

> It's just high school :)

What? The parent comment is asking: how do they know they wouldn't have done better for the past fifteen years if they hadn't started in high school.

Re: U.S. Surgeon General’s Advisory: Marijuana Use and the Developing Brain

#255
post #131

Earlier quoted context omitted.

Are the engineers you are referring to in developing brain stages? You are replying to OP who said from 16-18.. that is still fairly prime development.. your bay area engineers are probably mid 20's? That is quite different when we are talking about brain development.

They're probably referring to someone who starts getting high everyday, and quickly becomes "smoked out" - We all know someone like this. I used to get high a lot (when I was 21-23), and I stopped because I noticed myself becoming a shell of who I once was. When I wasn't high, nothing was fun anymore. It started off as saying things like "Bro this would be so much more fun if I was stoned", or "Dude, imagine getting…

Weed effects last for up to 8 hours. Weed messes with REM cycles. This means weed should be treated like coffee (no usage after 4pm) and obviously not before going to work. Meaning the best times to smoke are weekends and holidays, preferably right after you wake up at a normal hour (7-8am)

Re: U.S. Surgeon General’s Advisory: Marijuana Use and the Developing Brain

#256
post #193

Earlier quoted context omitted.

You didn't say anything about your age, which would be important given that the article is about the developing brain. It's already pretty understood that the negative impact is significantly less in the adult brain. The majority of people I went to HS with that were potheads are in exactly the types of jobs and whatnot that the Surgeon General suggests is most likely. Of course there are a lot of outliers. Nobody sa…

Correlation, not causation

That doesn't apply in this case, because the causation is well documented. The developing brain can suffer various types of delays when thc or just about any other intoxicant is distracting said developing brain's ability to actually develop.

Problems occur when the brain is too preoccupied in La La Land to develop optimally for the real world. There's a huge difference between the "thinker" and the "space cadet" when it comes to how one's brain handles thc in their youth.

Space cadets tend to stay space cadets. Thinkers tend to stay thinkers. The space cadet is who the Surgeon General is concerned about, because thc pretty much obliterates their chances of getting out of La La Land mentality.

Nobody says pot stops the brain from developing. You're going to get a notable Bell Curve. Some potheads go total 70's/80's movie revival mode. Others become Carl Sagan. Almost everyone around these people can identify which one is the Carl Sagan and which is the Tommy Chong (character) pretty early on. That's half of the pot humour in those movies, so it's not like only non-users notice this.

Re: U.S. Surgeon General’s Advisory: Marijuana Use and the Developing Brain

#257
post #84

Earlier quoted context omitted.

Would you care to speculate again about how much time I've spent reading their literature before this discussion? I promise you, it's non-zero. Please try not to dismiss people's positions that shallowly; it's a disservice to the conversation we're trying to have, and it's rude. I am involved in a number of communities that engage intentionally, even sacramentally, with psychedelics. The amount of sheer bullshit they…

Not OP, but FWIW your italicizing of drugabuse.gov also gave me the impression that you were dismissing it purely by domain. I did not ready any rudeness in your parent.

Thanks for your perspective, I appreciate it. I can see that being a legitimate read of the comment, if one punts on the guideline to assume good faith, and interpret people's arguments in the strongest light, rather than, e.g., dismiss them on the basis of formatting.

It's just disappointing when that happens, because I try to engage that way, and assume my comments will be treated the same.

EDIT: That said, I didn't exactly offer much in the way of argument there, did I?

Re: U.S. Surgeon General’s Advisory: Marijuana Use and the Developing Brain

#258
post #5

> Edible marijuana takes time to absorb and to produce its effects, increasing the risk of unintentional overdose No citation for this. Do they mean a larger than intended dose or a dose that results in a serious toxic reaction or death? Better source: Median lethal THC dose for a 70kg human estimated to be 4g [0], which is slightly over 1300 full joints (at 3mg per joint) [0]. I won't link them here, but a cursory w…

Is there a listed Median Lethal Dose (LD50) for THC or CBD? It is possible to overdose on nicotine if it's ingested (50mg ~60mg for a 150lbs adult, according to the CDC's website), but I'm not sure if there is such an amount defined for THC ingestion.

It depends on your weight and how much tolerance you have, but a fatal does could be as little as 2 grams (2000mg) of THC, which is about 100X what it takes to get high. Since marijuana is about 20% THC, and you only actually absorb about half of that when you smoke or injest it, the minimum lethal dose is probably about 20 grams, though some people may be able to tolerate a few times that amount. Fatal marijuana overdoses are rare, about 200 per year in the U.S., but they do happen. Claims that you can injest your body weight are based on articles written by advocates who can't do basic math.

Re: U.S. Surgeon General’s Advisory: Marijuana Use and the Developing Brain

#259
post #243

Earlier quoted context omitted.

Cannabis addiction, if that even exists, isn’t a bitch at all. Nicotine addiction is kind of a bitch. Opiate addiction is a bitch.

It does exist. It is a 'bitch' but those others are bastards.

You get addicted to dopamine release, not weed. Nicotine has addictive properties. Opioids have addictive properties. No one has ever sucked dick for a dimebag.

Re: U.S. Surgeon General’s Advisory: Marijuana Use and the Developing Brain

#260

Earlier quoted context omitted.

Is there a listed Median Lethal Dose (LD50) for THC or CBD? It is possible to overdose on nicotine if it's ingested (50mg ~60mg for a 150lbs adult, according to the CDC's website), but I'm not sure if there is such an amount defined for THC ingestion.

It's a comically large amount of THC to reach the LD50. 192mg/kg.

192mg/kg is on the higher end of estimates, which do range widely because they are based on animal studies. However, it's not comically large. Do the math, and it comes to just over 14 grams for a 75 kg (165 lb) adult. That's more than most people would ever consume in a day, but it's far less than the 600 gram lethal dose of alcohol for that same person. Alcohol kills far more people because it takes 100 - 250 grams of alcohol for a 75 kg adult to get drunk, so the lethal dose of alcohol is only about 5X the intoxicating dose vs. 100X the intoxicating dose for THC.
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