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U.S. Surgeon General’s Advisory: Marijuana Use and the Developing Brain

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Re: U.S. Surgeon General’s Advisory: Marijuana Use and the Developing Brain

#31

Post by Chardok »

numakerg wrote: post #5

> Edible marijuana takes time to absorb and to produce its effects, increasing the risk of unintentional overdose No citation for this. Do they mean a larger than intended dose or a dose that results in a serious toxic reaction or death? Better source: Median lethal THC dose for a 70kg human estimated to be 4g [0], which is slightly over 1300 full joints (at 3mg per joint) [0]. I won't link them here, but a cursory w…

Its referring to ingesting more than the desired amount, not "ODing" in the lethal sense.

Re: U.S. Surgeon General’s Advisory: Marijuana Use and the Developing Brain

#32

Post by enragedcacti »

aritmo wrote: post #14
40acres wrote: post #3

My brother smoked heavily during his teens and as a result developed schizophrenia / substance induced psychosis. It was generally terrifying to see him unable to complete thoughts and lose his train of thought. He's fine now but I definitely wouldn't be surprised if you told me those years knocked a couple of points off his IQ. I'm for decriminalization and legalization but at the core we need funding for long term…

Cannabis is meant for adults only. When the brain is developed in the teens, cannabis use may affect the development. Just like with alcohol.

Cannabis is not "meant" for anyone. It is a naturally occurring substance. Whether it has a negative impact on teens or adults is a completely separate question. Just like with alcohol.

Re: U.S. Surgeon General’s Advisory: Marijuana Use and the Developing Brain

#33

Post by inflatableDodo »

numakerg wrote: post #5

> Edible marijuana takes time to absorb and to produce its effects, increasing the risk of unintentional overdose No citation for this. Do they mean a larger than intended dose or a dose that results in a serious toxic reaction or death? Better source: Median lethal THC dose for a 70kg human estimated to be 4g [0], which is slightly over 1300 full joints (at 3mg per joint) [0]. I won't link them here, but a cursory w…

All the cookies are gone and the subject is has abandoned the study in favour of learning the ukelele.

Re: U.S. Surgeon General’s Advisory: Marijuana Use and the Developing Brain

#34

Post by bregma »

40acres wrote: post #3

My brother smoked heavily during his teens and as a result developed schizophrenia / substance induced psychosis. It was generally terrifying to see him unable to complete thoughts and lose his train of thought. He's fine now but I definitely wouldn't be surprised if you told me those years knocked a couple of points off his IQ. I'm for decriminalization and legalization but at the core we need funding for long term…

Unfortunately the fallacy of correlation-is-causation muddies the water here. Does self-medication cause incipient psychoses to fully manifest, or do those with incipient psychoses resort to self-medication in early stages in seeking to treat their symptoms?

Fortunately, it's still illegal to even study these things in America so we can comfortably resort to what we have faith in without the scourge of proof.

This goes just as much for the miracle of CBD oil (CBD rhymes with 'znake').

Re: U.S. Surgeon General’s Advisory: Marijuana Use and the Developing Brain

#35

Post by crashlander »

hartator wrote: post #8
40acres wrote: post #3

My brother smoked heavily during his teens and as a result developed schizophrenia / substance induced psychosis. It was generally terrifying to see him unable to complete thoughts and lose his train of thought. He's fine now but I definitely wouldn't be surprised if you told me those years knocked a couple of points off his IQ. I'm for decriminalization and legalization but at the core we need funding for long term…

This. I am all for legalization but it’s not a safe drug. Induced schizophrenia by weed can be a thing if you carry a specific gene.

I think you meant to say "Induced schizophrenia by weed could be a thing, but more research is needed". The causation and correlation between existing mental health issues and weed is not well understood. Correlation is not equal to causation...

Re: U.S. Surgeon General’s Advisory: Marijuana Use and the Developing Brain

#36

Post by mabbo »

40acres wrote: post #21
djsumdog wrote: post #6

Earlier quoted context omitted.

> as a result developed schizophrenia I'm sorry about your brother, but I want to point out this is anecdotal. Can cannibals lead to psychosis in people who are prone to it genetically, or are people who start experiencing delusions, bipolar and schizo-effective conditions just likely to escape using alcohol and marijuana? The exact cause/effect conditions here are a big unknown.

I can't say what truly caused it or what factor cannabis played, all I know is that the diagnosis was 'substance induced psychosis' and 'schizophrenia' -- the doctors were pretty stumped and that leads to my point that a lot more research is needed.

I have a similar situation with my own brother- skipping over many details for brevity. What I've always wondered was whether the marijuana caused the mental illness or whether the mental issues developing lead to a dependence on the marijuana to cope with the stress, anxiety, etc. Sure, there is a correlation there, but how certain are we which causes which?

Then again, psychotropic drugs when you're already dealing with problematic brain chemistry probably isn't a great idea for anyone.

Re: U.S. Surgeon General’s Advisory: Marijuana Use and the Developing Brain

#37

Post by rosser »

hartator wrote: post #16
djsumdog wrote: post #6

Earlier quoted context omitted.

> as a result developed schizophrenia I'm sorry about your brother, but I want to point out this is anecdotal. Can cannibals lead to psychosis in people who are prone to it genetically, or are people who start experiencing delusions, bipolar and schizo-effective conditions just likely to escape using alcohol and marijuana? The exact cause/effect conditions here are a big unknown.

Not the OP, but this is not anecdotal. Weed can develop schizophrenia in 4-5% of the population that carries a specific gene. Ref: https://www.drugabuse.gov/publications/research-reports/mari...

drugabuse.gov should probably not be considered an un-biased source on the topic of drugs of abuse. Some of their material will be propaganda and FUD.

Re: U.S. Surgeon General’s Advisory: Marijuana Use and the Developing Brain

#38

Post by x86_64Ubuntu »

hartator wrote: post #16
djsumdog wrote: post #6

Earlier quoted context omitted.

> as a result developed schizophrenia I'm sorry about your brother, but I want to point out this is anecdotal. Can cannibals lead to psychosis in people who are prone to it genetically, or are people who start experiencing delusions, bipolar and schizo-effective conditions just likely to escape using alcohol and marijuana? The exact cause/effect conditions here are a big unknown.

Not the OP, but this is not anecdotal. Weed can develop schizophrenia in 4-5% of the population that carries a specific gene. Ref: https://www.drugabuse.gov/publications/research-reports/mari...

And how much of the general population carries that specific gene? The 4-5 is a conditional probability.

Re: U.S. Surgeon General’s Advisory: Marijuana Use and the Developing Brain

#39

Post by SimbaOnSteroids »

djsumdog wrote: post #12
numakerg wrote: post #5

> Edible marijuana takes time to absorb and to produce its effects, increasing the risk of unintentional overdose No citation for this. Do they mean a larger than intended dose or a dose that results in a serious toxic reaction or death? Better source: Median lethal THC dose for a 70kg human estimated to be 4g [0], which is slightly over 1300 full joints (at 3mg per joint) [0]. I won't link them here, but a cursory w…

Is there a listed Median Lethal Dose (LD50) for THC or CBD? It is possible to overdose on nicotine if it's ingested (50mg ~60mg for a 150lbs adult, according to the CDC's website), but I'm not sure if there is such an amount defined for THC ingestion.

It's a comically large amount of THC to reach the LD50. 192mg/kg.

Re: U.S. Surgeon General’s Advisory: Marijuana Use and the Developing Brain

#40

Post by hprotagonist »

djsumdog wrote: post #30
hprotagonist wrote: post #11

The national academy has a very nice writeup on "The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research (2017)" which is by far the most comprehensive guide I'm aware of. http://nationalacademies.org/hmd/reports/2017/health-effects... The conclusions summary PDF has the highlights: http://nationalacademies.org/hmd/~/media/Files/Report%20File... Personally, i fi…

In ever US state where it is legal (Washington, Oregon, California, Colorado, Alaska, Mass., and 2020 Illinois and Michigan) I think the minimum age is 21. Sure people underage can get it, but there is an attempt being made to limit it to people at least 21. I knew parents who let their teenagers know they used it, but also told them they didn't want their kids using it until they were at least 18 (but if they wanted…

I've stuck electrodes in enough brains to be very, very conservative about what i'm comfortable allowing to cross the BBB in rapidly developing tissues :)
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